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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004202naa a2200325 4500
001oai:lup.lub.lu.se:77650d74-2b93-461f-9648-f2cbf92e2c07
003SwePub
008160404s1993 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/12962662 URI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Minthon, Lennartu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)psyk-lmi
2451 0a Oral tetrahydroaminoacridine treatment of Alzheimer's disease evaluated clinically and by regional cerebral blood flow and EEG
264 1c 1993
520 a Neurochemical evidence indicates that cognitive impairment in dementia of Alzheimer type (DAT) is related to degeneration of cholinergic neurons in the brain. A pharmacological approach is treatment with a cholinesterase inhibitor such as tetrahydroaminoacridine (THA). THA treatment of 17 patients with DAT was studied with a double-blind crossover design with three types of treatment, THA + lecithin, THA + placebo and placebo + placebo. Each treatment period was 6 weeks with wash out periods of 2 weeks. The treatment was evaluated with clinical ratings, psychometric testing, EEG and regional cerebral blood flow (rCBF) measurements. No significant clinical differences between treatment periods were found in the total sample, but marked individual differences were observed. The patients were subdivided into three outcome groups based on four clinical measures: 6 patients improved (responders), 5 patients were mainly unchanged, and 6 patients showed further deterioration during the trial period of 26 weeks. Pretreatment rCBF in responders differed significantly from that of the deteriorated patients. EEG showed more high frequency activity among responders. Hepatotoxic side effects were observed in several cases. Three subjects showed marked increases of liver enzymes, with normalization following dose reduction. The majority of patients who improved or remained unchanged during the study chose to continue THA treatment in an open trial.
7001 a Gustafson, Larsu Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pski-lon
7001 a Dalfelt, G4 aut
7001 a Hagberg, Bou Lund University,Lunds universitet,Institutionen för psykologi,Samhällsvetenskapliga institutioner och centrumbildningar,Samhällsvetenskapliga fakulteten,Department of Psychology,Departments of Administrative, Economic and Social Sciences,Faculty of Social Sciences4 aut0 (Swepub:lu)psyk-bha
7001 a Nilsson, Karinu Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-kan
7001 a Risberg, Jarlu Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)psyc-jri
7001 a Rosén, Ingmaru Lund University,Lunds universitet,Klinisk neurofysiologi,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Neurophysiology,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)knfl-irn
7001 a Seiving, B4 aut
7001 a Wendt, P E4 aut
7102 a Klinisk minnesforskningb Forskargrupper vid Lunds universitet4 org
7730 t Dementia (Switzerland)g 4:1, s. 32-42q 4:1<32-42x 1013-7424
8564 u http://www.ncbi.nlm.nih.gov/pubmed?term=Oral%20tetrahydroaminoacridine%20treatment%20of%20Alzheimer's%20disease%20evaluated%20clinically%20and%20by%20regional%20cerebral%20blood%20flow%20and%20EEGx freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/1296266

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