Zinc oxide nanoparticle removal from wounded human skin

Sökning: WFRF:(Sundh J) > Zinc oxide nanopart...

Aim: Nanoparticle removal from skin is relevant given the concern over topical nanoparticle toxicity. Zinc oxide nanoparticles (ZnO-NPs) are commonly used in sunscreens and their use is currently debated. This study explores the penetration and removal of ZnO-NPs from injured skin. Materials & methods:Ex vivo/in vivo human skin was tape-stripped and/or microneedled followed by ZnO-NP application. After 2 h, treated skin was washed three-times using soapy water. Multiphoton tomography assessed the ZnO-NP signal before and after washing. Results: Washing once removed over 85 and 83% of ZnO-NP signal from ex vivo intact and tape-stripped skin, respectively (p < 0.05) but only 28% (p = 0.5) was removed from puncture sites. A similar trend was found in vivo with removal of 85 and 93% of ZnO-NP signal from intact and tape-stripped skin, respectively (p < 0.05). Conclusion: Washing is effective for the removal of ZnO-NPs from superficial layers of intact and tape-stripped skin, but not from puncture wounds.

Sundh, Daniel,1985Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xsundd (författare)
Grice, J. E. (författare)
Roberts, M. S. (författare)
Soyer, H. P. (författare)
Prow, T. W. (författare)
Göteborgs universitetInstitutionen för neurovetenskap och fysiologi (creator_code:org_t)

Av författaren/redakt...: Raphael, A. P.; Sundh, Daniel, 1 ...; Grice, J. E.; Roberts, M. S.; Soyer, H. P.; Prow, T. W.

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