Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study.

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Fältnamn	Indikatorer	Metadata
000		04155naa a2200685 4500
001		oai:DiVA.org:umu-42549
003		SwePub
008		110408s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-425492 URI
024	7	a https://doi.org/10.1182/blood-2009-04-2151522 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Balgobind, Brian V4 aut
245	1 0	a Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia :b results of an international retrospective study.
264	1	b American Society of Hematology,c 2009
338		a print2 rdacarrier
520		a Translocations involving chromosome 11q23 frequently occur in pediatric acute myeloid leukemia (AML) and are associated with poor prognosis. In most cases, the MLL gene is involved, and more than 50 translocation partners have been described. Clinical outcome data of the 11q23-rearranged subgroups are scarce because most 11q23 series are too small for meaningful analysis of subgroups, although some studies suggest that patients with t(9;11)(p22;q23) have a more favorable prognosis. We retrospectively collected outcome data of 756 children with 11q23- or MLL-rearranged AML from 11 collaborative groups to identify differences in outcome based on translocation partners. All karyotypes were centrally reviewed before assigning patients to subgroups. The event-free survival of 11q23/MLL-rearranged pediatric AML at 5 years from diagnosis was 44% (+/- 5%), with large differences across subgroups (11% +/- 5% to 92% +/- 5%). Multivariate analysis identified the following subgroups as independent prognostic predictors: t(1;11)(q21;q23) (hazard ratio [HR] = 0.1, P = .004); t(6;11)(q27;q23) (HR = 2.2, P < .001); t(10;11)(p12;q23) (HR = 1.5, P = .005); and t(10;11)(p11.2;q23) (HR = 2.5, P = .005). We could not confirm the favorable prognosis of the t(9;11)(p22;q23) subgroup. We identified large differences in outcome within 11q23/MLL-rearranged pediatric AML and novel subgroups based on translocation partners that independently predict clinical outcome. Screening for these translocation partners is needed for accurate treatment stratification at diagnosis.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng
700	1	a Raimondi, Susana C4 aut
700	1	a Harbott, Jochen4 aut
700	1	a Zimmermann, Martin4 aut
700	1	a Alonzo, Todd A4 aut
700	1	a Auvrignon, Anne4 aut
700	1	a Beverloo, H Berna4 aut
700	1	a Chang, Myron4 aut
700	1	a Creutzig, Ursula4 aut
700	1	a Dworzak, Michael N4 aut
700	1	a Forestier, Eriku Umeå universitet,Pediatrik4 aut0 (Swepub:umu)erfo0007
700	1	a Gibson, Brenda4 aut
700	1	a Hasle, Henrik4 aut
700	1	a Harrison, Christine J4 aut
700	1	a Heerema, Nyla A4 aut
700	1	a Kaspers, Gertjan J L4 aut
700	1	a Leszl, Anna4 aut
700	1	a Litvinko, Nathalia4 aut
700	1	a Nigro, Luca Lo4 aut
700	1	a Morimoto, Akira4 aut
700	1	a Perot, Christine4 aut
700	1	a Pieters, Rob4 aut
700	1	a Reinhardt, Dirk4 aut
700	1	a Rubnitz, Jeffrey E4 aut
700	1	a Smith, Franklin O4 aut
700	1	a Stary, Jan4 aut
700	1	a Stasevich, Irina4 aut
700	1	a Strehl, Sabine4 aut
700	1	a Taga, Takashi4 aut
700	1	a Tomizawa, Daisuke4 aut
700	1	a Webb, David4 aut
700	1	a Zemanova, Zuzana4 aut
700	1	a Zwaan, C Michel4 aut
700	1	a van den Heuvel-Eibrink, Marry M4 aut
710	2	a Umeå universitetb Pediatrik4 org
773	0	t Bloodd : American Society of Hematologyg 114:12, s. 2489-2496q 114:12<2489-2496x 0006-4971x 1528-0020
856	4	u https://europepmc.org/articles/pmc2927031
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42549
856	4 8	u https://doi.org/10.1182/blood-2009-04-215152

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