Sökning: L773:1475 0961 > Heart filling excee...
Fältnamn | Indikatorer | Metadata |
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000 | 05023naa a2200433 4500 | |
001 | oai:lup.lub.lu.se:7b37519c-21d1-46e9-8d72-76117af27cc9 | |
003 | SwePub | |
008 | 190102s2019 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:140627465 | |
024 | 7 | a https://lup.lub.lu.se/record/7b37519c-21d1-46e9-8d72-76117af27cc92 URI |
024 | 7 | a https://doi.org/10.1111/cpf.125552 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1406274652 URI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Carlsson, Marcusu Lund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)klin-mca |
245 | 1 0 | a Heart filling exceeds emptying during late ventricular systole in patients with systolic heart failure and healthy subjects – a cardiac MRI study |
264 | c 2018-12-02 | |
264 | 1 | b Wiley,c 2019 |
520 | a Background: Total heart volume (THV) within the pericardium is not constant throughout the cardiac cycle and THV would intuitively be lowest at end systole. We have, however, observed a phase shift between ventricular outflow and atrial inflow which causes the minimum THV to occur before end systole. The aims were to explain the mechanism of the late-systolic net inflow to the heart and determine whether this net inflow is affected by increased cardiac output or systolic heart failure. Methods and Results: Healthy controls (n = 21) and patients with EF<35% (n = 14) underwent magnetic resonance imaging with flow measurements in vessels to and from the heart, and this was repeated in nine controls during 140 μgram kg−1 min−1 adenosine infusion. Minimum THV occurred 78 ± 6 ms before end of systolic ejection (8 ± 1% of the cardiac cycle) in controls. The late-systolic net inflow was 12·3 ± 1·1 ml or 6·0 ± 0·5% of total stroke volume (TSV). Cardiac output increased 66 ± 8% during adenosine but late-systolic net inflow to the heart did not change (P = 0·73). In patients with heart failure, late-systolic net inflow of the heart′s left side was lower (3·4 ± 0·5%) compared to healthy subjects (5·3 ± 0·6%, P = 0·03). Conclusions: Heart size increases before end systole due to a late-systolic net inflow which is unaffected by increased cardiac output. This may be explained by inertia of blood that flows into the atria generated by ventricular systole. The lower late-systolic net inflow in patients with systolic heart failure may be a measure of decreased ventricular filling due to decreased systolic function, thus linking systolic to diastolic dysfunction. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a cardiac output | |
653 | a cardiac pumping | |
653 | a diastolic dysfunction | |
700 | 1 | a Ugander, Martinu Karolinska Institutet,Lund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)klfy-mug |
700 | 1 | a Kanski, Mikaelu Lund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-mki |
700 | 1 | a Borgquist, Rasmusu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)medf-rbo |
700 | 1 | a Ekelund, Ulfu Lund University,Lunds universitet,Experimentell kärlforskning,Forskargrupper vid Lunds universitet,Experimental Vascular Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-uek |
700 | 1 | a Arheden, Håkanu Lund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)klfy-har |
710 | 2 | a Hjärt-MR-gruppen i Lundb Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Clinical Physiology and Functional Imagingd : Wileyg 39:3, s. 192-200q 39:3<192-200x 1475-0961x 1475-097X |
856 | 4 | u http://dx.doi.org/10.1111/cpf.12555x freey FULLTEXT |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cpf.12555 |
856 | 4 8 | u https://lup.lub.lu.se/record/7b37519c-21d1-46e9-8d72-76117af27cc9 |
856 | 4 8 | u https://doi.org/10.1111/cpf.12555 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140627465 |
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