SwePub
Sök i LIBRIS databas

  Utökad sökning

L773:1475 0961
 

Sökning: L773:1475 0961 > Heart filling excee...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005023naa a2200433 4500
001oai:lup.lub.lu.se:7b37519c-21d1-46e9-8d72-76117af27cc9
003SwePub
008190102s2019 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:140627465
024a https://lup.lub.lu.se/record/7b37519c-21d1-46e9-8d72-76117af27cc92 URI
024a https://doi.org/10.1111/cpf.125552 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1406274652 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
100a Carlsson, Marcusu Lund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)klin-mca
2451 0a Heart filling exceeds emptying during late ventricular systole in patients with systolic heart failure and healthy subjects – a cardiac MRI study
264 c 2018-12-02
264 1b Wiley,c 2019
520 a Background: Total heart volume (THV) within the pericardium is not constant throughout the cardiac cycle and THV would intuitively be lowest at end systole. We have, however, observed a phase shift between ventricular outflow and atrial inflow which causes the minimum THV to occur before end systole. The aims were to explain the mechanism of the late-systolic net inflow to the heart and determine whether this net inflow is affected by increased cardiac output or systolic heart failure. Methods and Results: Healthy controls (n = 21) and patients with EF<35% (n = 14) underwent magnetic resonance imaging with flow measurements in vessels to and from the heart, and this was repeated in nine controls during 140 μgram kg−1 min−1 adenosine infusion. Minimum THV occurred 78 ± 6 ms before end of systolic ejection (8 ± 1% of the cardiac cycle) in controls. The late-systolic net inflow was 12·3 ± 1·1 ml or 6·0 ± 0·5% of total stroke volume (TSV). Cardiac output increased 66 ± 8% during adenosine but late-systolic net inflow to the heart did not change (P = 0·73). In patients with heart failure, late-systolic net inflow of the heart′s left side was lower (3·4 ± 0·5%) compared to healthy subjects (5·3 ± 0·6%, P = 0·03). Conclusions: Heart size increases before end systole due to a late-systolic net inflow which is unaffected by increased cardiac output. This may be explained by inertia of blood that flows into the atria generated by ventricular systole. The lower late-systolic net inflow in patients with systolic heart failure may be a measure of decreased ventricular filling due to decreased systolic function, thus linking systolic to diastolic dysfunction.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
653 a cardiac output
653 a cardiac pumping
653 a diastolic dysfunction
700a Ugander, Martinu Karolinska Institutet,Lund University,Lunds universitet,Klinisk fysiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Physiology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)klfy-mug
700a Kanski, Mikaelu Lund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-mki
700a Borgquist, Rasmusu Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)medf-rbo
700a Ekelund, Ulfu Lund University,Lunds universitet,Experimentell kärlforskning,Forskargrupper vid Lunds universitet,Experimental Vascular Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-uek
700a Arheden, Håkanu Lund University,Lunds universitet,Hjärt-MR-gruppen i Lund,Forskargrupper vid Lunds universitet,Lund Cardiac MR Group,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)klfy-har
710a Hjärt-MR-gruppen i Lundb Forskargrupper vid Lunds universitet4 org
773t Clinical Physiology and Functional Imagingd : Wileyg 39:3, s. 192-200q 39:3<192-200x 1475-0961x 1475-097X
856u http://dx.doi.org/10.1111/cpf.12555x freey FULLTEXT
856u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cpf.12555
8564 8u https://lup.lub.lu.se/record/7b37519c-21d1-46e9-8d72-76117af27cc9
8564 8u https://doi.org/10.1111/cpf.12555
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:140627465

Hitta via bibliotek

Till lärosätets databas

Sök utanför SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy