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Sökning: L773:2162 4011 > Lymphoblastoid cell...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005248naa a2200565 4500
001oai:DiVA.org:uu-191016
003SwePub
008130109s2012 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:126382941
009oai:DiVA.org:liu-79040
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1910162 URI
0247 a https://doi.org/10.4161/onci.1.1.184002 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1263829412 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-790402 URI
040 a (SwePub)uud (SwePub)kid (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Rosén, Andersu Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)andro72
2451 0a Lymphoblastoid cell line with B1 cell characteristics established from a chronic lymphocytic leukemia clone by in vitro EBV infection
264 c 2014-11-04
264 1b Informa UK Limited,c 2012
338 a print2 rdacarrier
520 a Chronic lymphocytic leukemia (CLL) cells express the receptor for Epstein-Barr virus (EBV) and can be infected in vitro. Infected cells do not express the growth-promoting set of EBV-encoded genes and therefore they do not yield LCLs, in most experiments. With exceptional clones, lines were obtained however. We describe a new line, HG3, established by in vitro EBV-infection from an IGHV1-2 unmutated CLL patient clone. All cells expressed EBNA-2 and LMP-1, the EBV-encoded genes pivotal for transformation. The karyotype, FISH cytogenetics and SNP-array profile of the line and the patient's ex vivo clone showed biallelic 13q14 deletions with genomic loss of DLEU7, miR15a/miR16-1, the two micro-RNAs that are deleted in 50% of CLL cases. Further features of CLL cells were: expression of CD5/CD20/CD27/CD43 and release of IgM natural antibodies reacting with oxLDL-like epitopes on apoptotic cells (cf. stereotyped subset-1). Comparison with two LCLs established from normal B cells showed 32 genes expressed at higher levels (> 2-fold). Among these were LHX2 and LILRA. These genes may play a role in the development of the disease. LHX2 expression was shown in self-renewing multipotent hematopoietic stem cells, and LILRA4 codes for a receptor for bone marrow stromal cell antigen-2 that contributes to B cell development. Twenty-four genes were expressed at lower levels, among these PARD3 that is essential for asymmetric cell division. These genes may contribute to establish precursors of CLL clones by regulation of cellular phenotype in the hematopoietic compartment. Expression of CD5/CD20/CD27/CD43 and spontaneous production of natural antibodies may identify the CLL cell as a self-renewing B1 lymphocyte.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng
653 a Medical Science
653 a Medicinsk vetenskap
7001 a Bergh, Ann-Charlotteu Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)annbe93
7001 a Gogok, Peteru Karolinska Institutet; Stockholm, Sweden4 aut
7001 a Evaldsson, Chamillyu Linköpings universitet,Klinisk kemi,Hälsouniversitetet4 aut0 (Swepub:liu)chaga42
7001 a Lanemo Myhrinder, Annau Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)annla15
7001 a Hellqvist, Evau Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)evahe25
7001 a Rasul, Abuu Karolinska Institutet,Karolinska Institutet; Stockholm, Sweden4 aut
7001 a Björkholm, Magnusu Karolinska Institutet,Karolinska University Hospital; Stockholm, Sweden4 aut
7001 a Jansson, Mattiasu Uppsala universitet,Hematologi och immunologi,Uppsala University; Uppsala, Sweden4 aut0 (Swepub:uu)mattjans
7001 a Mansouri, Larryu Uppsala universitet,Hematologi och immunologi,Uppsala University; Uppsala, Sweden4 aut0 (Swepub:uu)maman377
7001 a Liu, Anquanu Karolinska Institutet; Stockholm, Sweden4 aut
7001 a Teh, Bin Teanu Van Andel Research Institute; Grand Rapids, MI USA4 aut
7001 a Rosenquist, Richardu Uppsala universitet,Hematologi och immunologi,Uppsala University; Uppsala, Sweden4 aut0 (Swepub:uu)richrose
7001 a Klein, Evau Karolinska Institutet,Karolinska Institutet; Stockholm, Sweden4 aut
7102 a Linköpings universitetb Cellbiologi4 org
7730 t Oncoimmunologyd : Informa UK Limitedg 1:1, s. 18-27q 1:1<18-27x 2162-4011x 2162-402X
8564 u https://www.tandfonline.com/doi/pdf/10.4161/onci.1.1.18400?needAccess=true
8564 u https://liu.diva-portal.org/smash/get/diva2:537953/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-191016
8564 8u https://doi.org/10.4161/onci.1.1.18400
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:126382941
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-79040

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