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Body mass index and risk of over 100 cancer forms and subtypes in 4.1 million individuals in Sweden : the obesity and disease development Sweden (ODDS) pooled cohort study

Sun, Ming (författare)
Department of Translational Medicine, Lund University, Malmö, Sweden
da Silva, Marisa (författare)
Department of Translational Medicine, Lund University, Malmö, Sweden
Bjørge, Tone (författare)
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway
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Fritz, Josef (författare)
Department of Translational Medicine, Lund University, Malmö, Sweden; Institute of Medical Statistics and Informatics, Medical University of Innsbruck, Innsbruck, Austria
Mboya, Innocent B. (författare)
Department of Translational Medicine, Lund University, Malmö, Sweden
Jerkeman, Mats (författare)
Division of Oncology, Lund University, Lund, Sweden
Stattin, Pär (författare)
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
Wahlström, Jens, 1972- (författare)
Umeå universitet,Avdelningen för hållbar hälsa
Michaëlsson, Karl (författare)
Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
van Guelpen, Bethany (författare)
Umeå universitet,Institutionen för diagnostik och intervention,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
Magnusson, Patrik K.E. (författare)
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Sandin, Sven (författare)
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, United States
Yin, Weiyao (författare)
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Lagerros, Ylva Trolle (författare)
Division of Clinical Epidemiology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden; Center for Obesity, Academic Specialist Center, Stockholm Health Services, Stockholm, Sweden
Ye, Weimin (författare)
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Nwaru, Bright (författare)
Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden
Kankaanranta, Hannu (författare)
Krefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Respiratory Medicine, Seinäjoki Central Hospital, Seinäjoki, Finland; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
Lönnberg, Lena (författare)
Center for Clinical Research, Region Västmanland, Uppsala University, Västerås, Sweden
Chabok, Abbas (författare)
Center for Clinical Research, Region Västmanland, Uppsala University, Västerås, Sweden
Isaksson, Karolin (författare)
Department of Clinical Sciences Lund, Lund University, Lund, Sweden; Department of Surgery, Kristianstad Hospital, Kristianstad, Sweden
Pedersen, Nancy L. (författare)
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Elmståhl, Sölve (författare)
Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
Lind, Lars (författare)
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
Hedman, Linnea (författare)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin
Häggström, Christel (författare)
Umeå universitet,Institutionen för diagnostik och intervention
Stocks, Tanja (författare)
Department of Translational Medicine, Lund University, Malmö, Sweden
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 (creator_code:org_t)
Elsevier, 2024
2024
Engelska.
Ingår i: The Lancet Regional Health. - : Elsevier. - 2666-7762. ; 45
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Obesity, assessed by body mass index (BMI), is an established risk factor for 13 cancers. We aimed to identify further potential obesity-related cancers and to quantify their association with BMI relative to that of established obesity-related cancers.Methods: Using Cox regression models on 4,142,349 individuals in Sweden (mean age 27.1 years at weight measurement), we calculated hazard ratios (HRs) for the association between BMI and the risk of 122 cancers and cancer subtypes, grouped by topography and morphology. Cancers with a positive association (i.e., HR >1) at an α-level of 0.05 for obesity (BMI ≥30 kg/m2) vs. normal weight (BMI 18.5–24.9 kg/m2) or per 5 kg/m2 higher BMI, for which obesity is not an established risk factor, were considered potentially obesity related.Findings: After 100.2 million person-years of follow-up, 332,501 incident cancer cases were recorded. We identified 15 cancers in men and 16 in women as potentially obesity related. These were cancers of the head and neck, gastrointestinal tract, malignant melanoma, genital organs, endocrine organs, connective tissue, and haematological malignancies. Among these, there was evidence of differential associations with BMI between subtypes of gastric cancer, small intestine cancer, cervical cancer, and lymphoid neoplasms (P values for heterogeneity in HRs <0.05). The HR (95% confidence interval) per 5 kg/m2 higher BMI was 1.17 (1.15–1.20) in men and 1.13 (1.11–1.15) in women for potential obesity-related cancers (51,690 cases), and 1.24 (1.22–1.26) in men and 1.12 (1.11–1.13) in women for established obesity-related cancers (84,384 cases). Interpretation: This study suggests a large number of potential obesity-related cancers could be added to already established ones. Importantly, the magnitudes of the associations were largely comparable to those of the already established obesity-related cancers. We also provide evidence of specific cancer subtypes driving some associations with BMI. Studies accounting for cancer-specific confounders are needed to confirm these findings.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Nyckelord

Body mass index
Cancer
Obesity

Publikations- och innehållstyp

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