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WFRF:(Franke James A)
 

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FältnamnIndikatorerMetadata
00013285naa a2200961 4500
001oai:DiVA.org:oru-49331
003SwePub
008160315s2016 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:133467000
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-493312 URI
0247 a https://doi.org/10.1038/ng.35282 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1334670002 URI
040 a (SwePub)orud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Ellinghaus, Davidu Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany4 aut
2451 0a Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
264 c 2016-03-14
264 1a New York, USA :b Nature Publishing Group,c 2016
338 a print2 rdacarrier
500 a Funding Agencies:German Federal Ministry of Education and Research (BMBF) 01ZX1306AEstonian Research Council IUT20-60Center of Excellence in Genomics (EXCEGEN)University of Tartu (SP1GVARENG)UK Department of Health via National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre awards to Guy's and St Thomas' National Health Service (NHS) Foundation TrustKing's College LondonUniversity of CambridgeGerman Federal Ministry of Education and Research (BMBF), within the context of National Genome Research Network 2 (NGFN-2)National Genome Research Network plus (NGFNplus)Integrated Genome Research Network (IG) MooDS 01GS08144  01GS08147Netherlands Organization for Scientific Research (NWO) 016.136.308US NIH 1R01AR063759  5U01GM092691-05  1UH2AR067677-01  U19AI111224-01  1R01DK084960-05Doris Duke Charitable Foundation 2013097Novo Nordisk Foundation NNF14CC0001H2020 project MedBioinformatics 634143Norwegian PSC Research Center
520 a We simultaneously investigated the genetic landscape of ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate pleiotropy and the relationship between these clinically related diseases. Using high-density genotype data from more than 86,000 individuals of European ancestry, we identified 244 independent multidisease signals, including 27 new genome-wide significant susceptibility loci and 3 unreported shared risk loci. Complex pleiotropy was supported when contrasting multidisease signals with expression data sets from human, rat and mouse together with epigenetic and expressed enhancer profiles. The comorbidities among the five immune diseases were best explained by biological pleiotropy rather than heterogeneity (a subgroup of cases genetically identical to those with another disease, possibly owing to diagnostic misclassification, molecular subtypes or excessive comorbidity). In particular, the strong comorbidity between primary sclerosing cholangitis and inflammatory bowel disease is likely the result of a unique disease, which is genetically distinct from classical inflammatory bowel disease phenotypes.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653 a Genetik
653 a Genetics
7001 a Jostins, Lukeu Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK4 aut
7001 a Spain, Sarah L.u Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK4 aut
7001 a Cortes, Adrianu Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK4 aut
7001 a Bethune, Jörnu Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany4 aut
7001 a Han, Buhmu Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea; Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea4 aut
7001 a Park, Yu Rangu Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea4 aut
7001 a Raychaudhuri, Soumyau Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge MA, United States; Division of Genetics, Brigham and Women's Hospital, Boston MA, United States; Division of Rheumatology, Brigham and Women's Hospital, Boston MA, United States4 aut
7001 a Pouget, Jennie G.u Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada4 aut
7001 a Hübenthal, Matthiasu Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany4 aut
7001 a Folseraas, Trineu Norwegian PSC Research Center, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway; K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Division of Cancer Medicine,Surgery and Transplantation, Oslo University Hospital, Oslo, Norway; Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway4 aut
7001 a Wang, Yunpengu Department of Neurosciences, University of California, San Diego, USA4 aut
7001 a Esko, Tonuu Estonian Genome Center, University of Tartu, Tartu, Estonia; Division of Endocrinology, Boston Children's Hospital, Cambridge MA, USA; Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge MA, USA4 aut
7001 a Metspalu, Andresu Estonian Genome Center, University of Tartu, Tartu, Estonia4 aut
7001 a Westra, Harm-Janu Program in Medical and Population Genetics, Broad Institute of mit and Harvard, Cambridge MA, United States; Division of Genetics, Brigham and Women's Hospital, Boston MA, United States; Division of Rheumatology, Brigham and Women's Hospital, Boston MA, United States; Department of Medicine, Harvard Medical School, Boston MA, United States4 aut
7001 a Franke, Ludeu University Medical Center Groningen, Department of Genetics, University of Groningen, Groningen, the Netherlands4 aut
7001 a Pers, Tune H.u Program in Medical and Population Genetics, Broad Institute of mit and Harvard, Cambridge MA, United States; Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge MA, United States; Novo Nordisk Foundation, Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark4 aut
7001 a Weersma, Rinse K.u Department of Gastroenterology and Hepatology, University Medical Center, University of Groningen, Groningen, the Netherlands4 aut
7001 a Collij, Valerieu Department of Gastroenterology and Hepatology, University Medical Center, University of Groningen, Groningen, the Netherlands4 aut
7001 a D'Amato, Maurou Karolinska Institutet4 aut
7001 a Halfvarson, Jonas,d 1970-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden4 aut0 (Swepub:oru)jshn
7001 a Jensen, Anders Boecku Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark4 aut
7001 a Lieb, Wolfgangu Institute of Epidemiology, University Hospital Schleswig-Holstein, Kiel, Germany; PopGen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany4 aut
7001 a Degenhardt, Franziskau Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany4 aut
7001 a Forstner, Andreas J.u Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany4 aut
7001 a Hofmann, Andreau Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany4 aut
7001 a The International IBD Genetics Consortium, (IIBDGC)4 aut
7001 a International Genetics of Ankylosing Spondylitis Consortium, (IGAS)4 aut
7001 a International PSC Study Group, (IPSCSG)4 aut
7001 a Genetic Analysis of Psoriasis Consortium, (GAPC)4 aut
7001 a Psoriasis Association Genetics Extension, (PAGE)4 aut
7001 a Schreiber, Stefanu Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany; Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany4 aut
7001 a Mrowietz, Ulrichu Department of Dermatology, University Hospital Schleswig-Holstein, Christian Albrechts University of Kiel, Kiel, Germany4 aut
7001 a Juran, Brian D.u Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic, College of Medicine, Rochester MN, USA4 aut
7001 a Lazaridis, Konstantinos N.u Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic, College of Medicine, Rochester MN, USA4 aut
7001 a Brunak, Sørenu Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark4 aut
7001 a Dale, Anders M.u Department of Neurosciences, University of California, San Diego, USA; Department of Radiology, University of California, San Diego, USA4 aut
7001 a Trembath, Richard C.u Division of Genetics and Molecular Medicine, King's College London, London, UK4 aut
7001 a Weidinger, Stephanu Department of Dermatology, University Hospital Schleswig-Holstein, Christian Albrechts University of Kiel, Kiel, Germany4 aut
7001 a Weichenthal, Michaelu Department of Dermatology, University Hospital Schleswig-Holstein, Christian Albrechts University of Kiel, Kiel, Germany4 aut
7001 a Ellinghaus, Evau Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany4 aut
7001 a Elder, James T.u Department of Dermatology, University of Michigan, Ann Arbor, USA; Ann Arbor Veterans Affairs Hospital, Ann Arbor, USA4 aut
7001 a Barker, Jonathan N. W. N.u St. John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, London, UK4 aut
7001 a Andreassen, Ole A.u NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital Ullevål, Oslo, Norway4 aut
7001 a McGovern, Dermot P.u F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, USA; Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, USA4 aut
7001 a Karlsen, Tom H.u Norwegian PSC Research Center, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway; K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Division of Cancer Medicine,Surgery and Transplantation, Oslo University Hospital, Oslo, Norway; Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway4 aut
7001 a Barrett, Jeffrey C.u Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK4 aut
7001 a Parkes, Milesu Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK4 aut
7001 a Brown, Matthew A.u University of Queensland Diamantina Institute, Translational Research Institute, Brisbane QLD, Australia; Institute of Health and Biomedical Innovation (IHBI), Translational Research Institute, Queensland University of Technology (QUT), Brisbane QLD, Australia4 aut
7001 a Franke, Andreu Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany4 aut
7102 a Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germanyb Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK4 org
7730 t Nature Geneticsd New York, USA : Nature Publishing Groupg 48:5, s. 510-518q 48:5<510-518x 1061-4036x 1546-1718
8564 u https://europepmc.org/articles/pmc4848113?pdf=render
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-49331
8564 8u https://doi.org/10.1038/ng.3528
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:133467000

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