Sökning: WFRF:(Hemmer M. T.) > A systems biology a...
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000 | 04223naa a2201021 4500 | |
001 | oai:prod.swepub.kib.ki.se:140913121 | |
003 | SwePub | |
008 | 240913s2019 | |||||||||||000 ||eng| | |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1409131212 URI |
024 | 7 | a https://doi.org/10.1038/s41467-019-09773-y2 DOI |
040 | a (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Madireddy, L4 aut |
245 | 1 0 | a A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis |
264 | c 2019-05-20 | |
264 | 1 | b Springer Science and Business Media LLC,c 2019 |
520 | a Genome-wide association studies (GWAS) have identified more than 50,000 unique associations with common human traits. While this represents a substantial step forward, establishing the biology underlying these associations has proven extremely difficult. Even determining which cell types and which particular gene(s) are relevant continues to be a challenge. Here, we conduct a cell-specific pathway analysis of the latest GWAS in multiple sclerosis (MS), which had analyzed a total of 47,351 cases and 68,284 healthy controls and found more than 200 non-MHC genome-wide associations. Our analysis identifies pan immune cell as well as cell-specific susceptibility genes in T cells, B cells and monocytes. Finally, genotype-level data from 2,370 patients and 412 controls is used to compute intra-individual and cell-specific susceptibility pathways that offer a biological interpretation of the individual genetic risk to MS. This approach could be adopted in any other complex trait for which genome-wide data is available. | |
700 | 1 | a Patsopoulos, NA4 aut |
700 | 1 | a Cotsapas, C4 aut |
700 | 1 | a Bos, SD4 aut |
700 | 1 | a Beecham, A4 aut |
700 | 1 | a McCauley, J4 aut |
700 | 1 | a Kim, K4 aut |
700 | 1 | a Jia, XM4 aut |
700 | 1 | a Santaniello, A4 aut |
700 | 1 | a Caillier, SJ4 aut |
700 | 1 | a Andlauer, TFM4 aut |
700 | 1 | a Barcellos, LF4 aut |
700 | 1 | a Berge, T4 aut |
700 | 1 | a Bernardinelli, L4 aut |
700 | 1 | a Martinelli-Boneschi, F4 aut |
700 | 1 | a Booth, DR4 aut |
700 | 1 | a Briggs, F4 aut |
700 | 1 | a Celius, EG4 aut |
700 | 1 | a Comabella, M4 aut |
700 | 1 | a Comi, G4 aut |
700 | 1 | a Cree, BAC4 aut |
700 | 1 | a D'Alfonso, S4 aut |
700 | 1 | a Dedham, K4 aut |
700 | 1 | a Duquette, P4 aut |
700 | 1 | a Efthimios, D4 aut |
700 | 1 | a Esposito, F4 aut |
700 | 1 | a Fontaine, B4 aut |
700 | 1 | a Gasperi, C4 aut |
700 | 1 | a Goris, A4 aut |
700 | 1 | a Dubois, B4 aut |
700 | 1 | a Gourraud, PA4 aut |
700 | 1 | a Hadjigeorgiou, G4 aut |
700 | 1 | a Haines, J4 aut |
700 | 1 | a Hawkins, C4 aut |
700 | 1 | a Hemmer, B4 aut |
700 | 1 | a Hintzen, R4 aut |
700 | 1 | a Horakova, D4 aut |
700 | 1 | a Isobe, N4 aut |
700 | 1 | a Kalra, S4 aut |
700 | 1 | a Kira, J4 aut |
700 | 1 | a Khalil, M4 aut |
700 | 1 | a Kockum, Iu Karolinska Institutet4 aut |
700 | 1 | a Lill, CM4 aut |
700 | 1 | a Lincoln, MR4 aut |
700 | 1 | a Luessi, F4 aut |
700 | 1 | a Martin, R4 aut |
700 | 1 | a Oturai, A4 aut |
700 | 1 | a Palotie, A4 aut |
700 | 1 | a Pericak-Vance, MA4 aut |
700 | 1 | a Henry, R4 aut |
700 | 1 | a Saarela, J4 aut |
700 | 1 | a Ivinson, A4 aut |
700 | 1 | a Olsson, Tu Karolinska Institutet4 aut |
700 | 1 | a Taylor, BV4 aut |
700 | 1 | a Stewart, GJ4 aut |
700 | 1 | a Harbo, HF4 aut |
700 | 1 | a Compston, A4 aut |
700 | 1 | a Hauser, SL4 aut |
700 | 1 | a Hafler, DA4 aut |
700 | 1 | a Zipp, F4 aut |
700 | 1 | a De Jager, P4 aut |
700 | 1 | a Sawcer, S4 aut |
700 | 1 | a Oksenberg, JR4 aut |
700 | 1 | a Baranzini, SE4 aut |
710 | 2 | a Karolinska Institutet4 org |
773 | 0 | t Nature communicationsd : Springer Science and Business Media LLCg 10:1, s. 2236-q 10:1<2236-x 2041-1723 |
856 | 4 | u https://www.nature.com/articles/s41467-019-09773-y.pdf |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140913121 |
856 | 4 8 | u https://doi.org/10.1038/s41467-019-09773-y |
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