The role of molecular oxygen in the formation of radiation-engineered multifunctional nanogels

Ditta, L. A. (författare)

Sabatino, M. A. (författare)

Dispenza, C. (författare)

(creator_code:org_t)

Elsevier, 2019
2019
Engelska.
Ingår i: European Polymer Journal. - : Elsevier. - 0014-3057 .- 1873-1945. ; 114, s. 164-175

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Abstract Ämnesord

Stäng

Nanogels are very promising biomedical nanodevices. The classic “radiation chemistry-based” approach to synthetize nanogels consists in the irradiation with pulsed electron beams of dilute, N 2 O-saturated, aqueous solutions of water-soluble polymers of the “crosslinking type”. Nanogels with controlled size and properties are produced in a single irradiation step with no recourse to initiators, organic solvents and surfactants. This paper combines experimental syntheses, performed with two e-beam irradiation setups and dose-ranges, starting from poly(N-vinyl pyrrolidone) solutions of various concentrations, both in N 2 O-saturated and air-saturated initial conditions, with the numerical simulations of the radiation chemistry of aqueous solutions of a radical scavanger exposed to the same irradiation conditions used in the experiments. This approach provides a methodology to predict the impact of system and irradiation conditions on the water radiation chemistry, which in turn affect the nanogel features in terms of molecular and physico-chemical properties. In particular, the crucial role of initial and transient concentration of molecular oxygen is revealed. This work also proposes a very simple and effective methodology to quantitatively measure the double bonds formed in the systems from disporportionation and chain scission reactions, competing with inter-/intra-molecular crosslinking.

Av författaren/redakt...: Ditta, L. A.; Dahlgren, Björn; Sabatino, M. A.; Dispenza, C.; Jonsson, Mats, 1 ...

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