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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005242naa a2200529 4500
001oai:DiVA.org:uu-531653
003SwePub
008240617s2024 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5316532 URI
0247 a https://doi.org/10.1002/mnfr.2023004652 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Raza, Ghulam Shereu Univ Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland.4 aut
2451 0a Effect of Aerobic Exercise and Time-Restricted Feeding on Metabolic Markers and Circadian Rhythm in Mice Fed with the High-Fat Diet
264 1b John Wiley & Sons,c 2024
338 a electronic2 rdacarrier
520 a Scope: Diet and exercise are significant players in obesity and metabolic diseases. Time-restricted feeding (tRF) has been shown to improve metabolic responses by regulating circadian clocks but whether it acts synergically with exercise remains unknown. It is hypothesized that forced exercise alone or combined with tRF alleviates obesity and its metabolic complications.Methods and resultsMale C57bl6 mice are fed with high-fat or a control diet for 12 weeks either ad libitum or tRF for 10 h during their active period. High-fat diet (HFD)-fed mice are divided into exercise (treadmill for 1 h at 12 m min(-1) alternate days for 9 weeks and 16 m min(-1) daily for the following 3 weeks) and non-exercise groups. tRF and tRF-Ex significantly decreased body weight, food intake, and plasma lipids, and improved glucose tolerance. However, exercise reduced only body weight and plasma lipids. tRF and tRF-Ex significantly downregulated Fasn, Hmgcr, and Srebp1c, while exercise only Hmgcr. HFD feeding disrupted clock genes, but exercise, tRF, and tRF-Ex coordinated the circadian clock genes Bmal1, Per2, and Rev-Erb alpha in the liver, adipose tissue, and skeletal muscles. Conclusion: HFD feeding disrupted clock genes in the peripheral organs while exercise, tRF, and their combination restored clock genes and improved metabolic consequences induced by high-fat diet feeding.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a circadian clocks
653 a exercise
653 a metabolic regulations
653 a obesity
653 a time-restricted feeding
7001 a Kaya, Yagmuru Istanbul Kent Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-34406 Istanbul, Turkiye.4 aut
7001 a Stenback, Villeu Univ Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland.4 aut
7001 a Sharma, Ravikantu Univ Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland.4 aut
7001 a Sodum, Naliniu Univ Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland.4 aut
7001 a Jagalur Mutt, Shivaprakashu Uppsala universitet,Institutionen för medicinsk cellbiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)shija511
7001 a Gagnon, Dominique D.u Univ Jyvaskyla, Fac Sports & Hlth Sci, Seminaarinkatu 15, Jyvaskyla 40014, Finland.;Univ Helsinki Makelankatu, Fac Med, Dept Sports & Exercise Med, Clin Sports & Exercise Med, Helsinki 00550, Finland.4 aut
7001 a Tulppo, Mikkou Univ Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland.4 aut
7001 a Jarvelin, Marjo-Riittau Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London SW72AZ, England.4 aut
7001 a Herzig, Karl-Heinzu Univ Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland.;Poznan Univ Med Sci, Pediat Inst, Pediat Gastroenterol & Metab Dis, PL-60572 Poznan, Poland.4 aut
7001 a Makela, Kari A.u Univ Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland.4 aut
7102 a Univ Oulu, Fac Med, Med Res Ctr, Res Unit Biomed & Internal Med, Aapistie 5, Oulu 90220, Finland.b Istanbul Kent Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-34406 Istanbul, Turkiye.4 org
7730 t Molecular Nutrition & Food Researchd : John Wiley & Sonsg 68:5q 68:5x 1613-4125x 1613-4133
8564 u https://doi.org/10.1002/mnfr.202300465y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1871298/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-531653
8564 8u https://doi.org/10.1002/mnfr.202300465

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