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FältnamnIndikatorerMetadata
00011603naa a2200673 4500
001oai:DiVA.org:uu-533511
003SwePub
008240628s2024 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:bf660671-5c86-4d55-ac58-11f217ea8aa3
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5335112 URI
0247 a https://doi.org/10.1001/jamaneurol.2023.48202 DOI
0247 a https://lup.lub.lu.se/record/bf660671-5c86-4d55-ac58-11f217ea8aa32 URI
040 a (SwePub)uud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Taccone, Fabio Silviou Univ Libre Bruxelles ULB, Hop Univ Bruxelles HUB, Dept Intens Care, Brussels, Belgium.;ROSC Network, Paris, France.,Université Libre de Bruxelles (ULB)4 aut
2451 0a Hypothermia vs Normothermia in Patients With Cardiac Arrest and Nonshockable Rhythm :b A Meta-Analysis
264 1b American Medical Association (AMA),c 2024
338 a print2 rdacarrier
520 a Importance  International guidelines recommend body temperature control below 37.8 °C in unconscious patients with out-of-hospital cardiac arrest (OHCA); however, a target temperature of 33 °C might lead to better outcomes when the initial rhythm is nonshockable.Objective  To assess whether hypothermia at 33 °C increases survival and improves function when compared with controlled normothermia in unconscious adults resuscitated from OHCA with initial nonshockable rhythm.Data Sources  Individual patient data meta-analysis of 2 multicenter, randomized clinical trials (Targeted Normothermia after Out-of-Hospital Cardiac Arrest [TTM2; NCT02908308] and HYPERION [NCT01994772]) with blinded outcome assessors. Unconscious patients with OHCA and an initial nonshockable rhythm were eligible for the final analysis.Study Selection  The study cohorts had similar inclusion and exclusion criteria. Patients were randomized to hypothermia (target temperature 33 °C) or normothermia (target temperature 36.5 to 37.7 °C), according to different study protocols, for at least 24 hours. Additional analyses of mortality and unfavorable functional outcome were performed according to age, sex, initial rhythm, presence or absence of shock on admission, time to return of spontaneous circulation, lactate levels on admission, and the cardiac arrest hospital prognosis score.Data Extraction and Synthesis  Only patients who experienced OHCA and had a nonshockable rhythm with all causes of cardiac arrest were included. Variables from the 2 studies were available from the original data sets and pooled into a unique database and analyzed. Clinical outcomes were harmonized into a single file, which was checked for accuracy of numbers, distributions, and categories. The last day of follow-up from arrest was recorded for each patient. Adjustment for primary outcome and functional outcome was performed using age, gender, time to return of spontaneous circulation, and bystander cardiopulmonary resuscitation.Main Outcomes and Measures  The primary outcome was mortality at 3 months; secondary outcomes included unfavorable functional outcome at 3 to 6 months, defined as a Cerebral Performance Category score of 3 to 5.Results  A total of 912 patients were included, 490 from the TTM2 trial and 422 from the HYPERION trial. Of those, 442 had been assigned to hypothermia (48.4%; mean age, 65.5 years; 287 males [64.9%]) and 470 to normothermia (51.6%; mean age, 65.6 years; 327 males [69.6%]); 571 patients had a first monitored rhythm of asystole (62.6%) and 503 a presumed noncardiac cause of arrest (55.2%). At 3 months, 354 of 442 patients in the hypothermia group (80.1%) and 386 of 470 patients in the normothermia group (82.1%) had died (relative risk [RR] with hypothermia, 1.04; 95% CI, 0.89-1.20; P = .63). On the last day of follow-up, 386 of 429 in the hypothermia group (90.0%) and 413 of 463 in the normothermia group (89.2%) had an unfavorable functional outcome (RR with hypothermia, 0.99; 95% CI, 0.87-1.15; P = .97). The association of hypothermia with death and functional outcome was consistent across the prespecified subgroups.Conclusions and Relevance  In this individual patient data meta-analysis, including unconscious survivors from OHCA with an initial nonshockable rhythm, hypothermia at 33 °C did not significantly improve survival or functional outcome.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
7001 a Dankiewicz, Josefu Lund Univ, Skane Univ Hosp Lund, Dept Cardiol, Lund, Sweden.,Skåne University Hospital4 aut0 (Swepub:lu)med-jfd
7001 a Cariou, Alainu ROSC Network, Paris, France.;Paris Cite Univ, Cochin Hosp, AP HP, Dept Intens Care, Paris, France.4 aut
7001 a Lilja, Giselau Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital,Lund Univ, Neurol Dept Clin Sci, Lund, Sweden.;Skane Univ Hosp, Dept Neurol, Lund, Sweden.4 aut0 (Swepub:lu)med-gal
7001 a Asfar, Pierreu CHU Angers, Dept Med Intens Reanimat, Angers, France.4 aut
7001 a Belohlavek, Janu Charles Univ Prague, Fac Med 1, Dept Med 2, Cardiovasc Med, Prague, Czech Republic.;Gen Univ Hosp, Prague, Czech Republic.,General University Hospital in Prague4 aut
7001 a Boulain, Thierryu Hop Source Orleans, Ctr Hosp Reg Orleans, Med Intens Care Unit, Orleans, France.4 aut
7001 a Colin, Gwenhaelu Dist Hosp Ctr, Med Surg Intens Care Unit, La Roche Sur Yon, France.4 aut
7001 a Cronberg, Tobiasu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital,Lund Univ, Neurol Dept Clin Sci, Lund, Sweden.;Skane Univ Hosp, Dept Neurol, Lund, Sweden.4 aut0 (Swepub:lu)efor-tcr
7001 a Frat, Jean-Pierreu Univ Poitiers, INSERM, CIC 1402, Grp IS ALIVE, Poitiers, France.,Poitiers University4 aut
7001 a Friberg, Hansu Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SWECRIT,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital,Lund Univ, Dept Clin Sci Anesthesiol & Intens Care, Lund, Sweden.;Skane Univ Hosp, Intens & Perioperat Care, Malmö, Sweden.4 aut0 (Swepub:lu)efor-hfr
7001 a Grejs, Anders M.u Aarhus Univ Hosp, Dept Intens Care Med, Aarhus, Denmark.;Aarhus Univ, Dept Clin Med, Aarhus, Denmark.,Aarhus University Hospital4 aut
7001 a Grillet, Guillaumeu Dist Hosp Ctr, Med Surg Intens Care Unit, Lorient, France.4 aut
7001 a Girardie, Patricku Univ Lille, CHU Lille, Fac Med, Med Intens Reanimat, Lille, France.,University of Lille4 aut
7001 a Haenggi, Matthiasu Univ Bern, Bern Univ Hosp, Inselspital, Dept Intens Care Med, Bern, Switzerland.,Bern University Hospital4 aut
7001 a Hovdenes, Janu Natl Hosp Norway, Dept Anesthesia & Intens Care, Oslo Univ Hosp, Oslo, Norway.,Norwegian Radium Hospital4 aut
7001 a Jakobsen, Janus Christianu Rigshosp, Copenhagen Univ Hosp, Ctr Clin Intervent Res, Copenhagen Trial Unit,Capital Reg, Copenhagen, Denmark.;Univ Southern Denmark, Fac Hlth Sci, Dept Reg Hlth Res, Odense, Denmark.,Copenhagen University Hospital,University of Southern Denmark4 aut
7001 a Levin, Helenau Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for cardiac arrest,Lund University Research Groups,Skåne University Hospital,Lund Univ, Dept Res & Educ, Lund, Sweden.;Skane Univ Hosp, Lund, Sweden.4 aut0 (Swepub:lu)ores-hal
7001 a Merdji, Hamidu Hop Univ Strasbourg, Nouvel Hop Civil, Serv Med Intens Reanimat, Strasbourg, France.;Univ Strasbourg UNISTRA, INSERM, UMR 1260, Regenerat Nanomed,Federat Med Translat Strasbourg, Strasbourg, France.,CHRU Nouvel Hôpital Civil4 aut
7001 a Njimi, Hassaneu Univ Libre Bruxelles ULB, Hop Univ Bruxelles HUB, Dept Intens Care, Brussels, Belgium.,Université Libre de Bruxelles (ULB)4 aut
7001 a Pelosi, Paolou Univ Genoa, San Martino Policlin Hosp, Dept Anesthesiol & Crit Care, IRCCS Oncol & Neurosci,Dept Surg Sci & Integrated, Genoa, Italy.,Ospedale Policlinico San Martino,University Hospital of Wales,Univ Hosp Wales, Adult Crit Care, Cardiff, Wales.4 aut
7001 a Rylander, Christianu Uppsala University,Uppsala universitet,Anestesiologi och intensivvård4 aut0 (Swepub:uu)chrry684
7001 a Saxena, Manoju George Inst Global Hlth, Crit Care & Trauma Div, Sydney, NSW, Australia.;St George Hosp, Dept Intens Care Med, Kogarah, NSW, Australia.,St George Hospital, Sidney,The George Institute for Global Health4 aut
7001 a Thomas, Mattu Southmead Hosp, Dept Anaesthesia, Bristol, Avon, England.4 aut
7001 a Young, Paul J.u Wellington Reg Hosp, Dept Intens Care, Capital & Coast Dist Hlth Board, Wellington, New Zealand.;Med Res Inst New Zealand, Wellington, New Zealand.;Monash Univ, Australian & New Zealand Intens Care Res Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Dept Crit Care, Melbourne, Vic, Australia.,Monash University,Wellington Hospital, New Zealand,University of Melbourne,Medical Research Institute of New Zealand4 aut
7001 a Wise, Matt P.u Univ Hosp Wales, Adult Crit Care, Cardiff, Wales.4 aut
7001 a Nielsen, Niklasu Univ Poitiers, INSERM, CIC 1402, Grp IS ALIVE, Poitiers, France.,Poitiers University4 aut
7001 a Lascarrou, Jean-Baptisteu ROSC Network, Paris, France.;CHU Nantes, Med Intens Reanimat, Nantes, France.;Univ Paris Cite, INSERM, PARCC, F-75015 Paris, France.,Nantes University Hospital4 aut
7102 a Univ Libre Bruxelles ULB, Hop Univ Bruxelles HUB, Dept Intens Care, Brussels, Belgium.;ROSC Network, Paris, France.b Université Libre de Bruxelles (ULB)4 org
7730 t JAMA Neurologyd : American Medical Association (AMA)g 81:2, s. 126-133q 81:2<126-133x 2168-6149x 2168-6157
8564 u http://dx.doi.org/10.1001/jamaneurol.2023.4820y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-533511
8564 8u https://doi.org/10.1001/jamaneurol.2023.4820
8564 8u https://lup.lub.lu.se/record/bf660671-5c86-4d55-ac58-11f217ea8aa3

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