WFRF:(Rieckmann Anna)
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- Rieckmann, AnnaUmeå universitet,Institutionen för strålningsvetenskaper (author)
Cognitive aging : the role of neurotransmitter systems
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- Cambridge :Cambridge University Press,2020
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:umu-224850
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-224850URI
- https://doi.org/10.1017/9781108552684.006DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
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Notes
- Much of the extant work in the cognitive neurosciences of aging has focused on identifying the neural correlates of age-related declines in episodic memory and working memory. This chapter reviews evidence from human studies that speaks to the hypothesis that age-related dysfunctions in specific neurotransmitter systems play a critical role in cognitive decline. Based in large part on results from functional neuroimaging studies including positron emission tomography (PET) and pharmacological functional magnetic resonance imaging (fMRI), we conclude that there is emerging evidence that dysfunctions in the dopamine, noradrenaline, and cholinergic systems play a critical role in age- related cognitive decline of working memory and episodic memory. These conclusions are important and encourage further study in order to tailor interventions that preserve cognitive functions in older age via augmentation of neurotransmitter functions.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
- Acetylcholine
- Alzheimer's disease
- Dopamine
- Episodic memory
- Hippocampus
- Locus coeruleus
- Magnetic resonance imaging
- Noradrenaline
- Positron emission tomography
- Prefrontal cortex
- Scopolamine
- Striatum
- Working memory
Added entries (persons, corporate bodies, meetings, titles ...)
- Nyberg, Lars,1966-Umeå universitet,Institutionen för strålningsvetenskaper(Swepub:umu)lany0001 (author)
- Umeå universitetInstitutionen för strålningsvetenskaper (creator_code:org_t)
Related titles
- In:The cambridge handbook of cognitive agingCambridge : Cambridge University Press, s. 82-100978110855268497811084283479781108449366
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