Sökning: WFRF:(Rubin J.) > A Genome-Wide Assoc...
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000 | 07096naa a2201489 4500 | |
001 | oai:lup.lub.lu.se:86ac4894-f029-4fcc-adae-61499537b83b | |
003 | SwePub | |
008 | 160401s2011 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-47670 | |
024 | 7 | a https://lup.lub.lu.se/record/21871592 URI |
024 | 7 | a https://doi.org/10.1161/CIRCGENETICS.110.9587282 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-476702 URI |
040 | a (SwePub)lud (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Wild, Philipp S.4 aut |
245 | 1 0 | a A Genome-Wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease |
264 | 1 | b American Heart Association/Lippincott, Williams & Wilkins,c 2011 |
520 | a Background-eQTL analyses are important to improve the understanding of genetic association results. We performed a genome-wide association and global gene expression study to identify functionally relevant variants affecting the risk of coronary artery disease (CAD). Methods and Results-In a genome-wide association analysis of 2078 CAD cases and 2953 control subjects, we identified 950 single-nucleotide polymorphisms (SNPs) that were associated with CAD at P<10(-3). Subsequent in silico and wet-laboratory replication stages and a final meta-analysis of 21 428 CAD cases and 38 361 control subjects revealed a novel association signal at chromosome 10q23.31 within the LIPA (lysosomal acid lipase A) gene (P=3.7 x 10(-8); odds ratio, 1.1; 95% confidence interval, 1.07 to 1.14). The association of this locus with global gene expression was assessed by genome-wide expression analyses in the monocyte transcriptome of 1494 individuals. The results showed a strong association of this locus with expression of the LIPA transcript (P=1.3 x 10(-96)). An assessment of LIPA SNPs and transcript with cardiovascular phenotypes revealed an association of LIPA transcript levels with impaired endothelial function (P=4.4 x 10(-3)). Conclusions-The use of data on genetic variants and the addition of data on global monocytic gene expression led to the identification of the novel functional CAD susceptibility locus LIPA, located on chromosome 10q23.31. The respective eSNPs associated with CAD strongly affect LIPA gene expression level, which was related to endothelial dysfunction, a precursor of CAD. (Circ Cardiovasc Genet. 2011;4:403-412.) | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a coronary artery disease | |
653 | a genome-wide association studies | |
653 | a gene | |
653 | a expression | |
653 | a genetic variation | |
653 | a genomics | |
653 | a eQTL | |
653 | a eSNP | |
653 | a LIPA | |
653 | a coronary artery disease | |
700 | 1 | a Zeller, Tanja4 aut |
700 | 1 | a Schillert, Arne4 aut |
700 | 1 | a Szymczak, Silke4 aut |
700 | 1 | a Sinning, Christoph R.4 aut |
700 | 1 | a Deiseroth, Arne4 aut |
700 | 1 | a Schnabel, Renate B.4 aut |
700 | 1 | a Lubos, Edith4 aut |
700 | 1 | a Keller, Till4 aut |
700 | 1 | a Eleftheriadis, Medea S.4 aut |
700 | 1 | a Bickel, Christoph4 aut |
700 | 1 | a Rupprecht, Hans J.4 aut |
700 | 1 | a Wilde, Sandra4 aut |
700 | 1 | a Rossmann, Heidi4 aut |
700 | 1 | a Diemert, Patrick4 aut |
700 | 1 | a Cupples, L. Adrienne4 aut |
700 | 1 | a Perret, Claire4 aut |
700 | 1 | a Erdmann, Jeanette4 aut |
700 | 1 | a Stark, Klaus4 aut |
700 | 1 | a Kleber, Marcus E.4 aut |
700 | 1 | a Epstein, Stephen E.4 aut |
700 | 1 | a Voight, Benjamin F.4 aut |
700 | 1 | a Kuulasmaa, Kari4 aut |
700 | 1 | a Li, Mingyao4 aut |
700 | 1 | a Schaefer, Arne S.4 aut |
700 | 1 | a Klopp, Norman4 aut |
700 | 1 | a Braund, Peter S.4 aut |
700 | 1 | a Sager, Hendrik4 aut |
700 | 1 | a Demissie, Serkalem4 aut |
700 | 1 | a Proust, Carole4 aut |
700 | 1 | a Koenig, Inke R.4 aut |
700 | 1 | a Wichmann, Heinz-Erich4 aut |
700 | 1 | a Reinhard, Wibke4 aut |
700 | 1 | a Hoffmann, Michael M.4 aut |
700 | 1 | a Virtamo, Jarmo4 aut |
700 | 1 | a Burnett, Mary Susan4 aut |
700 | 1 | a Siscovick, David4 aut |
700 | 1 | a Wiklund, Per Gunnaru Umeå universitet,Medicin4 aut0 (Swepub:umu)pewi0010 |
700 | 1 | a Qu, Liming4 aut |
700 | 1 | a El Mokthari, Nour Eddine4 aut |
700 | 1 | a Thompson, John R.4 aut |
700 | 1 | a Peters, Annette4 aut |
700 | 1 | a Smith, Albert V.4 aut |
700 | 1 | a Yon, Emmanuelle4 aut |
700 | 1 | a Baumert, Jens4 aut |
700 | 1 | a Hengstenberg, Christian4 aut |
700 | 1 | a Maerz, Winfried4 aut |
700 | 1 | a Amouyel, Philippe4 aut |
700 | 1 | a Devaney, Joseph4 aut |
700 | 1 | a Schwartz, Stephen4 aut |
700 | 1 | a Saarela, Olli4 aut |
700 | 1 | a Mehta, Nehal N.4 aut |
700 | 1 | a Rubin, Diana4 aut |
700 | 1 | a Silander, Kaisa4 aut |
700 | 1 | a Hall, Alistair S.4 aut |
700 | 1 | a Ferriers, Jean4 aut |
700 | 1 | a Harris, Tamara B.4 aut |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Kee, Frank4 aut |
700 | 1 | a Hakonarson, Hakon4 aut |
700 | 1 | a Schrezenmeir, Juergen4 aut |
700 | 1 | a Gudnason, Vilmundur4 aut |
700 | 1 | a Elosua, Roberto4 aut |
700 | 1 | a Arveiler, Dominique4 aut |
700 | 1 | a Evans, Alun4 aut |
700 | 1 | a Rader, Daniel J.4 aut |
700 | 1 | a Illig, Thomas4 aut |
700 | 1 | a Schreiber, Stefan4 aut |
700 | 1 | a Bis, Joshua C.4 aut |
700 | 1 | a Altshuler, David4 aut |
700 | 1 | a Kavousi, Maryam4 aut |
700 | 1 | a Witteman, Jaqueline C. M.4 aut |
700 | 1 | a Uitterlinden, Andre G.4 aut |
700 | 1 | a Hofman, Albert4 aut |
700 | 1 | a Folsom, Aaron R.4 aut |
700 | 1 | a Barbalic, Maja4 aut |
700 | 1 | a Boerwinkle, Eric4 aut |
700 | 1 | a Kathiresan, Sekar4 aut |
700 | 1 | a Reilly, Muredach P.4 aut |
700 | 1 | a O'Donnell, Christopher J.4 aut |
700 | 1 | a Samani, Nilesh J.4 aut |
700 | 1 | a Schunkert, Heribert4 aut |
700 | 1 | a Cambien, Francois4 aut |
700 | 1 | a Lackner, Karl J.4 aut |
700 | 1 | a Tiret, Laurence4 aut |
700 | 1 | a Salomaa, Veikko4 aut |
700 | 1 | a Munzel, Thomas4 aut |
700 | 1 | a Ziegler, Andreas4 aut |
700 | 1 | a Blankenberg, Stefan4 aut |
710 | 2 | a Umeå universitetb Medicin4 org |
773 | 0 | t Circulation: Cardiovascular Geneticsd : American Heart Association/Lippincott, Williams & Wilkinsg 4:4, s. 203-403q 4:4<203-403x 1942-325Xx 1942-3268 |
856 | 4 | u http://dx.doi.org/10.1161/CIRCGENETICS.110.958728x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/2187159 |
856 | 4 8 | u https://doi.org/10.1161/CIRCGENETICS.110.958728 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-47670 |
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