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Myocardial infarcti...
Myocardial infarction in relation to mercury and fatty acids from fish : a risk-benefit analysis based on pooled Finnish and Swedish data in men
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- Wennberg, Maria (author)
- Umeå universitet,Yrkes- och miljömedicin,Arcum
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- Strömberg, Ulf (author)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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- Bergdahl, Ingvar A (author)
- Umeå universitet,Yrkes- och miljömedicin,Arcum
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- Jansson, Jan-Håkan (author)
- Umeå universitet,Medicin
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Kauhanen, Jussi (author)
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- Norberg, Margareta (author)
- Umeå universitet,Epidemiologi och global hälsa,Arcum
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Salonen, Jukka T (author)
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- Skerfving, Staffan (author)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine
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Tuomainen, Tomi-Pekka (author)
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- Vessby, Bengt (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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Virtanen, Jyrki K (author)
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(creator_code:org_t)
- Elsevier BV, 2012
- 2012
- English.
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In: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 96:4, s. 706-713
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http://dx.doi.org/10...
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Abstract
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- Background: Exposure to methylmercury from fish has been associated with increased risk of myocardial infarction (MI) in some studies. At the same time, marine n-3 (omega-3) PUFAs are an inherent constituent of fish and are regarded as beneficial. To our knowledge, no risk-benefit model on the basis of data on methylmercury, PUFA, and MI risk has yet been presented.Objective: The objective of this study was to describe how exposure to both marine n-3 PUFAs and methylmercury relates to MI risk by using data from Finland and Sweden.Design: We used matched case-control sets from Sweden and Finland that were nested in population-based, prospective cohort studies. We included 361 men with MI from Sweden and 211 men with MI from Finland. MI risk was estimated in a logistic regression model with the amount of mercury in hair (hair-Hg) and concentrations of n-3 PUFAs (EPA and DHA) in serum (S-PUFA) as independent variables.Results: The median hair-Hg was 0.57 mu g/g in Swedish and 1.32 mu g/g in Finnish control subjects, whereas the percentage of S-PUFA was 4.21% and 3.83%, respectively. In combined analysis, hair-Hg was associated with higher (P = 0.005) and S-PUFA with lower (P = 0.011) MI risk. Our model indicated that even a small change in fish consumption (ie, by increasing S-PUFA by 1%) would prevent 7% of MIs, despite a small increase in mercury exposure. However, at a high hair-Hg, the modeled beneficial effect of PUFA on MI risk was counteracted by methylmercury.Conclusions: Exposure to methylmercury was associated with increased risk of MI, and higher S-PUFA concentrations were associated with decreased risk of MI. Thus, MI risk may be reduced by the consumption of fish high in PUFAs and low in methylmercury.Am J Clin Nutr 2012;96:706-13.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
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- art (subject category)
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Wennberg, Maria
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Strömberg, Ulf
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Bergdahl, Ingvar ...
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Jansson, Jan-Håk ...
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Kauhanen, Jussi
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Norberg, Margare ...
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Salonen, Jukka T
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Skerfving, Staff ...
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Tuomainen, Tomi- ...
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Vessby, Bengt
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Virtanen, Jyrki ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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MEDICAL AND HEAL ...
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Umeå University
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Lund University
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Uppsala University