Diagnostic performance of CT-derived resting distal to aortic pressure ratio (resting Pd/Pa) vs. CT-derived fractional flow reserve (CT-FFR) in coronary lesion severity assessment

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Fältnamn	Indikatorer	Metadata
000		04515naa a2200481 4500
001		oai:DiVA.org:kth-318992
003		SwePub
008		220927s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3189922 URI
024	7	a https://doi.org/10.21037/atm-21-43252 DOI
040		a (SwePub)kth
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Li, Quanu Capital Med Univ, Div Cardiol, Ctr Coronary Artery Dis, Beijing Anzhen Hosp, Beijing 100029, Peoples R China.4 aut
245	1 0	a Diagnostic performance of CT-derived resting distal to aortic pressure ratio (resting Pd/Pa) vs. CT-derived fractional flow reserve (CT-FFR) in coronary lesion severity assessment
264		c 2021-09
264	1	b AME Publishing Company,c 2021
338		a print2 rdacarrier
500		a QC 20220927
520		a Background: Computed tomography-derived fractional flow reserve (CT-FFR) has emerged as a promising non-invasive substitute for fractional flow reserve (FFR) measurement. Normally, CT-FFR providing functional significance of coronary artery disease (CAD) by using a simplified total coronary resistance index (TCRI) model. Yet the error or discrepancy caused by this simplified model remains unclear. Methods: A total of 20 consecutive patients with suspected CAD who underwent CTA and invasive FFR measurement were retrospectively analyzed. CT-FFR and CT-(Pd/Pa)rest values derived from the coronary CTA images. The diagnostic performance of CT-FFR and CT-(Pd/Pa)rest were evaluated on a per-vessel level using C statistics with invasive FFR<0.80 as the reference standard. Results: Of the 25 vessels eventually analyzed, the prevalence of functionally significant CAD were 64%. The Youden index of the ROC curve indicated that the best cutoff value of invasive resting Pd/Pa was 0.945 for identifying functionally significant lesions. Sensitivity, specificity, negative predictive value, positive predictive value and accuracy were 85%, 91%, 92%, 83% and 88% for CT-(Pd/Pa)rest and 85%, 58% 69%, 78% and 72% for CT-FFR. Area under the receiver-operating characteristic curve (AUC) to detect functionally significant stenoses of CT-(Pd/Pa)rest and CT-FFR were 0.87 and 0.90. Conclusions: In this study, the results suggest CT-derived resting Pd/Pa has a potential advantage over CT-FFR in triaging patients for revascularization.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Fysiologi0 (SwePub)301062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Physiology0 (SwePub)301062 hsv//eng
653		a Fractional flow reserve (FFR)
653		a computational fluid dynamics
653		a coronary CT angiography
653		a pressure ratio
700	1	a Zhang, Yangu Capital Med Univ, Div Cardiol, Ctr Coronary Artery Dis, Beijing Anzhen Hosp, Beijing 100029, Peoples R China.4 aut
700	1	a Wang, Chunliang,d 1980-u KTH,Medicinsk avbildning,Shenzhen Escope Tech Inc, Shenzhen, Peoples R China.4 aut0 (Swepub:kth)u1tbkeej
700	1	a Dong, Shimingu Second Mil Med Univ, Changzheng Hosp, Dept Cardiol, Shanghai, Peoples R China.4 aut
700	1	a Mao, Yijinu Shenzhen Escope Tech Inc, Shenzhen, Peoples R China.4 aut
700	1	a Tang, Yidau Peking Univ Third Hosp, Dept Cardiovasc Med, Beijing 100191, Peoples R China.4 aut
700	1	a Zeng, Yongu Capital Med Univ, Div Cardiol, Ctr Coronary Artery Dis, Beijing Anzhen Hosp, Beijing 100029, Peoples R China.4 aut
710	2	a Capital Med Univ, Div Cardiol, Ctr Coronary Artery Dis, Beijing Anzhen Hosp, Beijing 100029, Peoples R China.b Medicinsk avbildning4 org
773	0	t Annals of Translational Medicined : AME Publishing Companyg 9:17q 9:17x 2305-5839x 2305-5847
856	4	u https://atm.amegroups.com/article/viewFile/78877/pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-318992
856	4 8	u https://doi.org/10.21037/atm-21-4325

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