L773:0145 6008
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Role of feeding-related pathways in alcohol dependence: A focus on sweet preference, NPY, and ghrelin.
- Leggio, L (author)
- Addolorato, G (author)
- Cippitelli, A (author)
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- Kampov-Polevoy, AB (author)
- Swift, RM (author)
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- (creator_code:org_t)
- 2010-11-08
- 2011
- English.
- In: Alcoholism: clinical and experimental research. - : Wiley. - 0145-6008. ; 35:2, s. 194-202
- Research review (peer-reviewed)
Abstract
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- Converging research evidence suggests that alcohol and food-seeking behaviors share common neural pathways. There is preclinical and clinical evidence linking the consumption of sweets to alcohol intake in both animals and humans. In addition, a growing body of animal and human literature suggests the involvement of "feeding-related" peptides in alcohol-seeking behavior. In particular, both central and peripheral appetitive peptides have shown a possible role in alcohol dependence. The present mini-review will summarize the literature on the link between sweet preference and alcohol dependence, and on the role of feeding-related peptides in alcohol dependence. Specifically, in an attempt to narrow the field, the present mini-review will focus on 2 specific pathways, the central neuropeptide Y and the peripheral gut peptide ghrelin. Although more research is needed, data available suggest that studying feeding-related pathways in alcohol dependence may have theoretic, biologic, diagnostic, and therapeutic implications.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Alcohol Craving; Alcohol Dependence; Appetite; Feeding-Related Pathways; Feeding-Related Peptides; Ghrelin; Neuropeptide Y; Sweet Preference
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- ref (subject category)
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- Addolorato, G
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- University of Gothenburg
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