Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men

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Fältnamn	Indikatorer	Metadata
000		06172naa a2201021 4500
001		oai:DiVA.org:umu-144108
003		SwePub
008		180126s2017 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:uu-365904
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1441082 URI
024	7	a https://doi.org/10.1371/journal.pone.01877412 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3659042 URI
040		a (SwePub)umud (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Watts, Eleanor L.4 aut
245	1 0	a Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men
264		c 2017-12-27
264	1	b Public Library of Science (PLoS),c 2017
338		a electronic2 rdacarrier
520		a Introduction: Sex hormones have been implicated in the etiology of a number of diseases. To better understand disease etiology and the mechanisms of disease-risk factor associations, this analysis aimed to investigate the associations of anthropometric, sociodemographic and behavioural factors with a range of circulating sex hormones and sex hormone-binding globulin.Methods: Statistical analyses of individual participant data from 12,330 male controls aged 25–85 years from 25 studies involved in the Endogenous Hormones Nutritional Biomarkers and Prostate Cancer Collaborative Group. Analysis of variance was used to estimate geometric means adjusted for study and relevant covariates.Results: Older age was associated with higher concentrations of sex hormone-binding globulin and dihydrotestosterone and lower concentrations of dehydroepiandrosterone sulfate, free testosterone, androstenedione, androstanediol glucuronide and free estradiol. Higher body mass index was associated with higher concentrations of free estradiol, androstanediol glucuronide, estradiol and estrone and lower concentrations of dihydrotestosterone, testosterone, sex hormone-binding globulin, free testosterone, androstenedione and dehydroepiandrosterone sulfate. Taller height was associated with lower concentrations of androstenedione, testosterone, free testosterone and sex hormone-binding globulin and higher concentrations of androstanediol glucuronide. Current smoking was associated with higher concentrations of androstenedione, sex hormone-binding globulin and testosterone. Alcohol consumption was associated with higher concentrations of dehydroepiandrosterone sulfate, androstenedione and androstanediol glucuronide. East Asians had lower concentrations of androstanediol glucuronide and African Americans had higher concentrations of estrogens. Education and marital status were modestly associated with a small number of hormones.Conclusion: Circulating sex hormones in men are strongly associated with age and body mass index, and to a lesser extent with smoking status and alcohol consumption.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
700	1	a Appleby, Paul N.4 aut
700	1	a Albanese, Demetrius4 aut
700	1	a Black, Amanda4 aut
700	1	a Chan, June M.4 aut
700	1	a Chen, Chu4 aut
700	1	a Cirillo, Piera M.4 aut
700	1	a Cohn, Barbara A.4 aut
700	1	a Cook, Michael B.4 aut
700	1	a Donovan, Jenny L.4 aut
700	1	a Ferrucci, Luigi4 aut
700	1	a Garland, Cedric F.4 aut
700	1	a Giles, Graham G.4 aut
700	1	a Goodman, Phyllis J.4 aut
700	1	a Habel, Laurel A.4 aut
700	1	a Haiman, Christopher A.4 aut
700	1	a Holly, Jeff M. P.4 aut
700	1	a Hoover, Robert N.4 aut
700	1	a Kaaks, Rudolf4 aut
700	1	a Knekt, Paul4 aut
700	1	a Kolonel, Laurence N.4 aut
700	1	a Kubo, Tatsuhiko4 aut
700	1	a Le Marchand, Loic4 aut
700	1	a Luostarinen, Tapio4 aut
700	1	a Maclnnis, Robert J.4 aut
700	1	a Maenpaa, Hanna O.4 aut
700	1	a Mannisto, Satu4 aut
700	1	a Metter, E. Jeffrey4 aut
700	1	a Milne, Roger L.4 aut
700	1	a Nomura, Abraham M. Y.4 aut
700	1	a Oliver, Steven E.4 aut
700	1	a Parsons, J. Kellogg4 aut
700	1	a Peeters, Petra H.4 aut
700	1	a Platz, Elizabeth A.4 aut
700	1	a Riboli, Elio4 aut
700	1	a Ricceri, Fulvio4 aut
700	1	a Rinaldi, Sabina4 aut
700	1	a Rissanen, Harri4 aut
700	1	a Sawada, Norie4 aut
700	1	a Schaefer, Catherine A.4 aut
700	1	a Schenk, Jeannette M.4 aut
700	1	a Stanczyk, Frank Z.4 aut
700	1	a Stampfer, Meir4 aut
700	1	a Stattin, Päru Uppsala universitet,Umeå universitet,Urologi och andrologi,Urologkirurgi4 aut0 (Swepub:uu)parst892
700	1	a Stenman, Ulf-Hakan4 aut
700	1	a Tjonneland, Anne4 aut
700	1	a Trichopoulou, Antonia4 aut
700	1	a Thompson, Ian M.4 aut
700	1	a Tsugane, Shoichiro4 aut
700	1	a Vatten, Lars4 aut
700	1	a Whittemore, Alice S.4 aut
700	1	a Ziegler, Regina G.4 aut
700	1	a Allen, Naomi E.4 aut
700	1	a Key, Timothy J.4 aut
700	1	a Travis, Ruth C.4 aut
710	2	a Umeå universitetb Urologi och andrologi4 org
773	0	t PLOS ONEd : Public Library of Science (PLoS)g 12:12q 12:12x 1932-6203
856	4	u https://doi.org/10.1371/journal.pone.0187741y Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:1177784/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0187741&type=printable
856	4	u https://uu.diva-portal.org/smash/get/diva2:1263355/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-144108
856	4 8	u https://doi.org/10.1371/journal.pone.0187741
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-365904

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Av författaren/redakt...: Watts, Eleanor L ...; Appleby, Paul N.; Albanese, Demetr ...; Black, Amanda; Chan, June M.; Chen, Chu; visa fler...; Cirillo, Piera M ...; Cohn, Barbara A.; Cook, Michael B.; Donovan, Jenny L ...; Ferrucci, Luigi; Garland, Cedric ...; Giles, Graham G.; Goodman, Phyllis ...; Habel, Laurel A.; Haiman, Christop ...; Holly, Jeff M. P ...; Hoover, Robert N ...; Kaaks, Rudolf; Knekt, Paul; Kolonel, Laurenc ...; Kubo, Tatsuhiko; Le Marchand, Loi ...; Luostarinen, Tap ...; Maclnnis, Robert ...; Maenpaa, Hanna O ...; Mannisto, Satu; Metter, E. Jeffr ...; Milne, Roger L.; Nomura, Abraham ...; Oliver, Steven E ...; Parsons, J. Kell ...; Peeters, Petra H ...; Platz, Elizabeth ...; Riboli, Elio; Ricceri, Fulvio; Rinaldi, Sabina; Rissanen, Harri; Sawada, Norie; Schaefer, Cather ...; Schenk, Jeannett ...; Stanczyk, Frank ...; Stampfer, Meir; Stattin, Pär; Stenman, Ulf-Hak ...; Tjonneland, Anne; Trichopoulou, An ...; Thompson, Ian M.; Tsugane, Shoichi ...; Vatten, Lars; Whittemore, Alic ...; Ziegler, Regina ...; Allen, Naomi E.; Key, Timothy J.; Travis, Ruth C.; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

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