IDAC-Dose 2.1, an internal dosimetry program for diagnostic nuclear medicine based on the ICRP adult reference voxel phantoms

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Fältnamn	Indikatorer	Metadata
000		05725naa a2200601 4500
001		oai:DiVA.org:umu-141966
003		SwePub
008		171206s2017 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:a6960af8-83e6-490e-b165-4ec97ec3b7d0
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1419662 URI
024	7	a https://doi.org/10.1186/s13550-017-0339-32 DOI
024	7	a https://lup.lub.lu.se/record/a6960af8-83e6-490e-b165-4ec97ec3b7d02 URI
040		a (SwePub)umud (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Andersson, Martinu Lund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)med-ma3
245	1 0	a IDAC-Dose 2.1, an internal dosimetry program for diagnostic nuclear medicine based on the ICRP adult reference voxel phantoms
264		c 2017-11-03
264	1	b Springer Berlin/Heidelberg,c 2017
338		a electronic2 rdacarrier
520		a Background: To date, the estimated radiation-absorbed dose to organs and tissues in patients undergoing diagnostic examinations in nuclear medicine is derived via calculations based on models of the human body and the biokinetic behaviour of the radiopharmaceutical. An internal dosimetry computer program, IDAC-Dose2.1, was developed based on the International Commission on Radiological Protection (ICRP)-specific absorbed fractions and computational framework of internal dose assessment given for reference adults in ICRP Publication 133. The program uses the radionuclide decay database of ICRP Publication 107 and considers 83 different source regions irradiating 47 target tissues, defining the effective dose as presented in ICRP Publications 60 and 103. The computer program was validated against another ICRP dosimetry program, Dose and Risk Calculation (DCAL), that employs the same computational framework in evaluation of occupational and environmental intakes of radionuclides. IDAC-Dose2.1 has a sub-module for absorbed dose calculations in spherical structures of different volumes and composition; this sub-module is intended for absorbed dose estimates in radiopharmaceutical therapy. For nine specific alpha emitters, the absorbed dose contribution from their decay products is also included in the committed absorbed dose calculations. Results: The absorbed doses and effective dose of I-131-iodide determined by IDAC-Dose2.1 were validated against the dosimetry program DCAL, showing identical results. IDAC-Dose2.1 was used to calculate absorbed doses for intravenously administered F-18-FDG and orally administered Tc-99m-pertechnetate and I-131-iodide, three frequently used radiopharmaceuticals. Using the tissue weighting factors from ICRP Publication 103, the effective dose per administered activity was estimated to be 0.016 mSv/MBq for F-18-FDG, 0.014 mSv/MBq for Tc-99m-pertechnetate, and 16 mSv/MBq for I-131-iodide. Conclusions: The internal dosimetry program IDAC-Dose2.1 was developed and applied to three radiopharmaceuticals for validation against DCAL and to generate improved absorbed dose estimations for diagnostic nuclear medicine using specific absorbed fraction values of the ICRP computational voxel phantoms. The sub-module for absorbed dose calculations in spherical structures 1 mm to 9 cm in diameter and different tissue composition was included to broaden the clinical usefulness of the program. The IDAC-Dose2.1 program is free software for research and available for download at http://www.idac-dose.org.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
653		a Internal dosimetry
653		a ICRP
653		a IDAC
653		a DCAL
653		a Effective dose
653		a Radiopharmaceuticals
653		a Diagnostic nuclear dicine
653		a DCAL
653		a Diagnostic nuclear medicine
653		a Effective dose
653		a ICRP
653		a IDAC
653		a Internal dosimetry
653		a Radiopharmaceuticals
700	1	a Johansson, Lennartu Umeå University,Umeå universitet,Radiofysik4 aut0 (Swepub:lu)jur-lj0
700	1	a Eckerman, Keithu Oak Ridge National Laboratory4 aut
700	1	a Mattsson, Sörenu Lund University,Lunds universitet,Medicinsk strålningsfysik, Malmö,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)rfa-sma
710	2	a Medicinsk strålningsfysik, Malmöb Forskargrupper vid Lunds universitet4 org
773	0	t EJNMMI Researchd : Springer Berlin/Heidelbergg 7q 7x 2191-219X
856	4	u https://doi.org/10.1186/s13550-017-0339-3y Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:1163273/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://ejnmmires.springeropen.com/track/pdf/10.1186/s13550-017-0339-3
856	4	u http://dx.doi.org/10.1186/s13550-017-0339-3y FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-141966
856	4 8	u https://doi.org/10.1186/s13550-017-0339-3
856	4 8	u https://lup.lub.lu.se/record/a6960af8-83e6-490e-b165-4ec97ec3b7d0

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