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A risk score based ...
A risk score based on real-world data to predict early death in acute promyelocytic leukemia
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- Österroos, Albin (författare)
- Uppsala universitet,Uppsala University,Uppsala Univ, Sweden,Hematologi
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- Maia, Tânia (författare)
- Department of Clinical Hematology, University Hospital Center of São João, Porto, Portugal,Univ Hosp Ctr Sao Joao, Dept Clin Hematol, Porto, Portugal.
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- Eriksson, Anna, 1977- (författare)
- Uppsala universitet,Uppsala University,Uppsala Univ, Sweden,Hematologi
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- Jädersten, Martin (författare)
- Karolinska Institutet
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- Lazarevic, Vladimir (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital,Skane Univ Hosp, Dept Hematol, Lund, Sweden.;Lund Univ, Stem Cell Ctr, Dept Hematol, Dept Lab Med, Lund, Sweden.
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- Wennström, Lovisa (författare)
- Department of Hematology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Hematol, Gothenburg, Sweden.
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- Antunovic, Petar (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US,Linköping Univ Hosp, Dept Hematol, Linköping, Sweden.
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- Cammenga, Jörg (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US,Linköping Univ Hosp, Dept Hematol, Linköping, Sweden.
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- Deneberg, Stefan (författare)
- Karolinska Institutet
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- Lorenz, Fryderyk (författare)
- Department of Hematology, Norrland University Hospital, Umeå, Sweden,Norrland Univ Hosp, Dept Hematol, Umeå, Sweden.
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- Möllgård, Lars (författare)
- Department of Hematology, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Dept Hematol, Gothenburg, Sweden.
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- Uggla, Bertil, 1962- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Division of Hematology,Örebro University Hospital,Örebro Univ Hosp, Dept Med, Div Hematol, Örebro, Sweden.
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- Ölander, Emma (författare)
- Department of Hematology, Sundsvall Hospital, Sundsvall, Sweden,Sundsvall Hosp, Dept Hematol, Sundsvall, Sweden.
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- Aguiar, Eliana (författare)
- Department of Clinical Hematology, University Hospital Center of São João, Porto, Portugal,Univ Hosp Ctr Sao Joao, Dept Clin Hematol, Porto, Portugal.
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- Trigo, Fernanda (författare)
- Department of Clinical Hematology, University Hospital Center of São João, Porto, Portugal,Univ Hosp Ctr Sao Joao, Dept Clin Hematol, Porto, Portugal.
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- Höglund, Martin (författare)
- Uppsala universitet,Uppsala University,Uppsala Univ, Sweden,Hematologi
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- Juliusson, Gunnar (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital,Skane Univ Hosp, Dept Hematol, Lund, Sweden.;Lund Univ, Stem Cell Ctr, Dept Hematol, Dept Lab Med, Lund, Sweden.
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- Lehmann, Sören (författare)
- Uppsala universitet,Uppsala University,Karolinska University Hospital,Uppsala Univ, Sweden; Karolinska Univ Hosp, Sweden,Hematologi,Karolinska Univ Hosp, Dept Hematol, Stockholm, Sweden.
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(creator_code:org_t)
- 2022-01-27
- 2022
- Engelska.
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Ingår i: Haematologica. - : Ferrata Storti Foundation. - 0390-6078 .- 1592-8721. ; 107:7, s. 1528-1537
- Relaterad länk:
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https://doi.org/10.3...
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https://haematologic...
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http://dx.doi.org/10... (free)
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https://liu.diva-por... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- With increasingly effective treatments, early death (ED) has become the predominant reason for therapeutic failure in patients with acute promyelocytic leukemia (APL). To better prevent ED, patients with high-risk of ED must be identified. Our aim was to develop a score that predicts the risk of ED in a real-life setting. We used APL patients in the population based Swedish AML Registry (n=301) and a Portuguese hospital-based registry (n=129) as training and validation cohorts, respectively. The cohorts were comparable with respect to age (median, 54 and 53 years) and ED rate (19.6% and 18.6%). The score was developed by logistic regression analyses, risk-per-quantile assessment and scoring based on ridge regression coefficients from multivariable penalized logistic regression analysis. White blood cell count, platelet count and age were selected by this approach as the most significant variables for predicting ED. The score identified low-, high-and very high-risk patients with ED risks of 4.8%, 20.2% and 50.9% respectively in the training cohort and with 6.7%, 25.0% and 36.0% as corresponding values for the validation cohort. The score identified an increased risk of ED already at sub-normal and normal white blood cell counts and, consequently, it was better at predicting ED risk than the Sanz score (AUROC 0.77 vs. 0.64). In summary, we here present an externally validated and population-based risk score to predict ED risk in a real-world setting, identifying patients with the most urgent need of aggressive ED prevention. The results also suggest that increased vigilance for ED is already necessary at sub-normal/normal white blood cell counts.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Österroos, Albin
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Maia, Tânia
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Eriksson, Anna, ...
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Jädersten, Marti ...
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Lazarevic, Vladi ...
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Wennström, Lovis ...
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visa fler...
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Antunovic, Petar
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Cammenga, Jörg
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Deneberg, Stefan
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Lorenz, Fryderyk
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Möllgård, Lars
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Uggla, Bertil, 1 ...
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Ölander, Emma
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Aguiar, Eliana
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Trigo, Fernanda
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Höglund, Martin
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Juliusson, Gunna ...
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Lehmann, Sören
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Haematologica
- Av lärosätet
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Örebro universitet
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Lunds universitet
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Linköpings universitet
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Uppsala universitet
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Karolinska Institutet