Sökning: WFRF:(Buchbinder D) > Characteristics of ...
Fältnamn | Indikatorer | Metadata |
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000 | 05926naa a2201021 4500 | |
001 | oai:DiVA.org:uu-374020 | |
003 | SwePub | |
008 | 190117s2019 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:140223142 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3740202 URI |
024 | 7 | a https://doi.org/10.1016/j.bbmt.2018.09.0312 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1402231422 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Norkin, Maxim4 aut |
245 | 1 0 | a Characteristics of Late Fatal Infections after Allogeneic Hematopoietic Cell Transplantation |
264 | 1 | b Elsevier BV,c 2019 |
338 | a print2 rdacarrier | |
520 | a We analyzed late fatal infections (LFIs) in allogeneic stem cell transplantation (HCT) recipients reported to the Center for International Blood and Marrow Transplant Research. We analyzed the incidence, infection types, and risk factors contributing to LFI in 10,336 adult and 5088 pediatric subjects surviving for ≥2 years after first HCT without relapse. Among 2245 adult and 377 pediatric patients who died, infections were a primary or contributory cause of death in 687 (31%) and 110 (29%), respectively. At 12 years post-HCT, the cumulative incidence of LFIs was 6.4% (95% confidence interval [CI], 5.8% to 7.0%) in adults, compared with 1.8% (95% CI, 1.4% to 2.3%) in pediatric subjects; P < .001). In adults, the 2 most significant risks for developing LFI were increasing age (20 to 39, 40 to 54, and ≥55 years versus 18 to 19 years) with hazard ratios (HRs) of 3.12 (95% CI, 1.33 to 7.32), 3.86 (95% CI, 1.66 to 8.95), and 5.49 (95% CI, 2.32 to 12.99) and a history of chronic graft-versus-host disease GVHD (cGVHD) with ongoing immunosuppression at 2 years post-HCT compared with no history of GVHD with (HR, 3.87; 95% CI, 2.59 to 5.78). In pediatric subjects, the 3 most significant risks for developing LFI were a history of cGVHD with ongoing immunosuppression (HR, 9.49; 95% CI, 4.39 to 20.51) or without ongoing immunosuppression (HR, 2.7; 95% CI, 1.05 to 7.43) at 2 years post-HCT compared with no history of GVHD, diagnosis of inherited abnormalities of erythrocyte function compared with diagnosis of acute myelogenous leukemia (HR, 2.30; 95% CI, 1.19 to 4.42), and age >10 years (HR, 1.92; 95% CI, 1.15 to 3.2). This study emphasizes the importance of continued vigilance for late infections after HCT and institution of support strategies aimed at decreasing the risk of cGVHD. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
653 | a Adults | |
653 | a Hematopoietic cell transplantation | |
653 | a Infection | |
653 | a Late fatal infection | |
653 | a Pediatrics | |
700 | 1 | a Shaw, Bronwen E4 aut |
700 | 1 | a Brazauskas, Ruta4 aut |
700 | 1 | a Tecca, Heather R4 aut |
700 | 1 | a Leather, Helen L4 aut |
700 | 1 | a Gea-Banacloche, Juan4 aut |
700 | 1 | a T Kamble, Rammurti4 aut |
700 | 1 | a DeFilipp, Zachariah4 aut |
700 | 1 | a Jacobsohn, David A4 aut |
700 | 1 | a Ringden, Olleu Karolinska Institutet4 aut |
700 | 1 | a Inamoto, Yoshihiro4 aut |
700 | 1 | a A Kasow, Kimberly4 aut |
700 | 1 | a Buchbinder, David4 aut |
700 | 1 | a Shaw, Peter4 aut |
700 | 1 | a Hematti, Peiman4 aut |
700 | 1 | a Schears, Raquel4 aut |
700 | 1 | a Badawy, Sherif M4 aut |
700 | 1 | a Lazarus, Hillard M4 aut |
700 | 1 | a Bhatt, Neel4 aut |
700 | 1 | a Horn, Biljana4 aut |
700 | 1 | a Chhabra, Saurabh4 aut |
700 | 1 | a M Page, Kristin4 aut |
700 | 1 | a Hamilton, Betty4 aut |
700 | 1 | a Hildebrandt, Gerhard C4 aut |
700 | 1 | a Yared, Jean A4 aut |
700 | 1 | a Agrawal, Vaibhav4 aut |
700 | 1 | a M Beitinjaneh, Amer4 aut |
700 | 1 | a Majhail, Navneet4 aut |
700 | 1 | a Kindwall-Keller, Tamila4 aut |
700 | 1 | a Olsson, Richard F.u Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden4 aut0 (Swepub:uu)riols677 |
700 | 1 | a Schoemans, Helene4 aut |
700 | 1 | a Gale, Robert Peter4 aut |
700 | 1 | a Ganguly, Siddhartha4 aut |
700 | 1 | a A Ahmed, Ibrahim4 aut |
700 | 1 | a Schouten, Harry C4 aut |
700 | 1 | a L Liesveld, Jane4 aut |
700 | 1 | a Khera, Nandita4 aut |
700 | 1 | a Steinberg, Amir4 aut |
700 | 1 | a Shah, Ami J4 aut |
700 | 1 | a Solh, Melhem4 aut |
700 | 1 | a Marks, David I4 aut |
700 | 1 | a Rybka, Witold4 aut |
700 | 1 | a Aljurf, Mahmoud4 aut |
700 | 1 | a Dietz, Andrew C4 aut |
700 | 1 | a Gergis, Usama4 aut |
700 | 1 | a George, Biju4 aut |
700 | 1 | a Seo, Sachiko4 aut |
700 | 1 | a Flowers, Mary E D4 aut |
700 | 1 | a Battiwalla, Minoo4 aut |
700 | 1 | a Savani, Bipin N4 aut |
700 | 1 | a Riches, Marcie L4 aut |
700 | 1 | a Wingard, John R4 aut |
710 | 2 | a Karolinska Institutetb Centrum för klinisk forskning i Sörmland (CKFD)4 org |
773 | 0 | t Biology of blood and marrow transplantationd : Elsevier BVg 25:2, s. 362-368q 25:2<362-368x 1083-8791x 1523-6536 |
856 | 4 | u http://www.bbmt.org/article/S1083879118305986/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-374020 |
856 | 4 8 | u https://doi.org/10.1016/j.bbmt.2018.09.031 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140223142 |
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