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  • Meidtner, KarinaGerman Institute of Human Nutrition,German Center for Diabetes Research (author)

Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2017-11-22
  • American Diabetes Association,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-147482
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-147482URI
  • https://doi.org/10.2337/dc17-1080DOI
  • https://lup.lub.lu.se/record/e45f2fbc-593b-4133-93a3-c33227a5b398URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVE: Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes.RESEARCH DESIGN AND METHODS: The case-cohort comprised 9,347 case subjects and 12,301 subcohort participants from eight European countries. Single nucleotide polymorphisms (SNPs) were selected from genome-wide association studies on iron status biomarkers and candidate gene studies. A ferritin-related gene score was constructed. Multiplicative and additive interactions of heme iron and SNPs as well as the gene score were evaluated using Cox proportional hazards regression.RESULTS: Higher heme iron intake (per 1 SD) was associated with higher ferritin levels (β = 0.113 [95% CI 0.082; 0.144]), but not with transferrin (−0.019 [−0.043; 0.006]) or transferrin saturation (0.016 [−0.006; 0.037]). Five SNPs located in four genes (rs1799945 [HFE H63D], rs1800562 [HFE C282Y], rs236918 [PCK7], rs744653 [SLC40A1], and rs855791 [TMPRSS6V736A]) were associated with ferritin. We did not detect an interaction of heme iron and the gene score on the risk of diabetes in the overall study population (Padd = 0.16, Pmult = 0.21) but did detect a trend toward a negative interaction in men (Padd = 0.04, Pmult = 0.03).CONCLUSIONS: We found no convincing evidence that the interplay of dietary and genetic factors related to body iron status associates with type 2 diabetes risk above the level expected from the sum or product of the two individual exposures.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Podmore, ClaraUniversity of Cambridge (author)
  • Kroger, JanineGerman Institute of Human Nutrition (author)
  • van der Schouw, Yvonne T.University Medical Center Utrecht (author)
  • Bendinelli, BenedettaCancer Research and Prevention Institute (ISPO),German Center for Diabetes Research,German Institute of Human Nutrition (author)
  • Agnoli, ClaudiaIstituto Nazionale dei Tumori (author)
  • Arriola, LarraitzBiodonostia Health Research Institute,Public Health Division of Gipuzkoa,CIBER Epidemiology and Public Health (CIBERESP) (author)
  • Barricarte, AurelioNavarre Public Health Institute (ISPN),CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA) (author)
  • Boeing, HeinerGerman Institute of Human Nutrition (author)
  • Cross, Amanda J.Imperial College London,International Agency for Research on Cancer, World Health Organization (author)
  • Dow, CourtneyCentre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay,Institut Gustave Roussy (author)
  • Ekblom, KimUmeå University,Umeå universitet,Klinisk kemi(Swepub:umu)kimekm00 (author)
  • Fagherazzi, GuyInstitut Gustave Roussy,University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP) (author)
  • Franks, Paul W.Umeå University,Umeå universitet,Avdelningen för medicin,Department of Clinical Sciences, Lund University, Malmö, Sweden(Swepub:lu)med-plf (author)
  • Gunter, Marc J.International Agency for Research on Cancer, World Health Organization (author)
  • Huerta, Jose MariaBiodonostia Health Research Institute,Murcia Regional Health Council (author)
  • Jakszyn, PaulaRamon Llull University,Catalan Institute of Oncology (author)
  • Jenab, Mazda (author)
  • Katzke, Verena A.German Cancer Research Centre (author)
  • Key, Timothy J.University of Oxford (author)
  • Khaw, Kay TeeUniversity of Cambridge (author)
  • Kuhn, TilmanGerman Cancer Research Centre (author)
  • Kyro, CecilieDanish Cancer Society (author)
  • Mancini, Francesca RomanaInstitut Gustave Roussy,University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP) (author)
  • Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (author)
  • Nilsson, Peter M.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)medf-pni (author)
  • Overvad, KimAarhus University,Aalborg University (author)
  • Palli, DomenicoCancer Research and Prevention Institute (ISPO) (author)
  • Panico, SalvatoreUniversity of Naples Federico II (author)
  • Quiros, J. RamonPublic Health Directorate (author)
  • Rodriguez-Barranco, MiguelCIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP) (author)
  • Sacerdote, CarlottaCitta' della Salute e della Scienza Hospital-University of Turin,Human Genetics Foundation (HuGeF) (author)
  • Sluijs, IvonneUniversity Medical Center Utrecht (author)
  • Stepien, MagdalenaInternational Agency for Research on Cancer, World Health Organization (author)
  • Tjonneland, AnneDanish Cancer Society (author)
  • Tumino, RosarioL’ Associazione Iblea per la Ricerca Epidemiologica (A.I.R.E.),Civic and M.P Arezzo Hospital (author)
  • Forouhi, Nita G.University of Cambridge (author)
  • Sharp, Stephen J.University of Cambridge (author)
  • Langenberg, ClaudiaUniversity of Cambridge (author)
  • Schulze, Matthias B. (author)
  • Riboli, ElioImperial College London (author)
  • Wareham, Nicholas J.University of Cambridge (author)
  • German Institute of Human NutritionGerman Center for Diabetes Research (creator_code:org_t)

Related titles

  • In:Diabetes Care: American Diabetes Association41:2, s. 277-2850149-59921935-5548

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