WFRF:(Dave J A)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 07775naa a2200985 4500 | |
| 001 | oai:lup.lub.lu.se:770bbf34-e18f-4407-803a-7a3c439a7090 | |
| 003 | SwePub | |
| 008 | 170811s2017 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/770bbf34-e18f-4407-803a-7a3c439a70902 URI |
| 024 | 7 | a https://doi.org/10.1056/NEJMoa16132102 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Faries, B.u Saint John's Health Center4 aut |
| 245 | 1 0 | a Completion dissection or observation for sentinel-node metastasis in melanoma |
| 264 | 1 | c 2017 |
| 300 | a 12 s. | |
| 520 | a BACKGROUND Sentinel-lymph-node biopsy is associated with increased melanoma-specific survival (i.e., survival until death from melanoma) among patients with node-positive intermediatethickness melanomas (1.2 to 3.5 mm). The value of completion lymph-node dissection for patients with sentinel-node metastases is not clear. METHODS In an international trial, we randomly assigned patients with sentinel-node metastases detected by means of standard pathological assessment or a multimarker molecular assay to immediate completion lymph-node dissection (dissection group) or nodal observation with ultrasonography (observation group). The primary end point was melanoma-specific survival. Secondary end points included disease-free survival and the cumulative rate of nonsentinel-node metastasis. RESULTS Immediate completion lymph-node dissection was not associated with increased melanomaspecific survival among 1934 patients with data that could be evaluated in an intention-Totreat analysis or among 1755 patients in the per-protocol analysis. In the per-protocol analysis, the mean (-SE) 3-year rate of melanoma-specific survival was similar in the dissection group and the observation group (86-1.3% and 86-1.2%, respectively; P = 0.42 by the logrank test) at a median follow-up of 43 months. The rate of disease-free survival was slightly higher in the dissection group than in the observation group (68-1.7% and 63-1.7%, respectively; P = 0.05 by the log-rank test) at 3 years, based on an increased rate of disease control in the regional nodes at 3 years (92-1.0% vs. 77-1.5%; P<0.001 by the log-rank test); these results must be interpreted with caution. Nonsentinel-node metastases, identified in 11.5% of the patients in the dissection group, were a strong, independent prognostic factor for recurrence (hazard ratio, 1.78; P = 0.005). Lymphedema was observed in 24.1% of the patients in the dissection group and in 6.3% of those in the observation group. CONCLUSIONS Immediate completion lymph-node dissection increased the rate of regional disease control and provided prognostic information but did not increase melanoma-specific survival among patients with melanoma and sentinel-node metastases. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 700 | 1 | a Thompson, J. F.u University of California, Los Angeles4 aut |
| 700 | 1 | a Cochran, Alistair J.u Jonsson Comprehensive Cancer Center4 aut |
| 700 | 1 | a Andtbacka, R. H.u Huntsman Cancer Institute4 aut |
| 700 | 1 | a Mozzillo, Nicolau Saint John's Health Center4 aut |
| 700 | 1 | a Zager, J. S.u H. Lee Moffitt Cancer Center & Research Institute4 aut |
| 700 | 1 | a Jahkola, Tiinau Helsinki University Central Hospital4 aut |
| 700 | 1 | a Bowles, T. L.u Intermountain Medical Center4 aut |
| 700 | 1 | a Testori, Au European Institute of Oncology4 aut |
| 700 | 1 | a Beitsch, P. D.u Dallas Surgical Group4 aut |
| 700 | 1 | a Hoekstra, H Ju University Medical Center Groningen4 aut |
| 700 | 1 | a Moncrieff, M.u Norfolk and Norwich University Hospital NHS Trust4 aut |
| 700 | 1 | a Ingvar, C.u Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Melanoma Study Group,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)kir-cin |
| 700 | 1 | a Wouters, M. W. J. M.u Netherlands Cancer Institute4 aut |
| 700 | 1 | a Sabel, M. S.u University of Michigan4 aut |
| 700 | 1 | a Levine, E. A.u Wake Forest University4 aut |
| 700 | 1 | a Agnese, D.u Ohio State University4 aut |
| 700 | 1 | a Henderson, Mu Peter MacCallum Cancer Centre4 aut |
| 700 | 1 | a Dummer, R.u University of Zurich4 aut |
| 700 | 1 | a Rossi-Alvarez, Cu University of Padova4 aut |
| 700 | 1 | a Neves, R. I.u Penn State Hershey Cancer Institute4 aut |
| 700 | 1 | a Trocha, S. D.u Saint Louis University School of Medicine4 aut |
| 700 | 1 | a Wright, Alan Fu Tom Baker Cancer Centre4 aut |
| 700 | 1 | a Byrd, D. R.u University of Washington4 aut |
| 700 | 1 | a Matter, M.u Lausanne University Hospital4 aut |
| 700 | 1 | a Hsueh, E.u Tom Baker Cancer Centre4 aut |
| 700 | 1 | a MacKenzie-Ross, A.u Guy's and St Thomas' NHS Foundation Trust4 aut |
| 700 | 1 | a Johnson, D. B.4 aut |
| 700 | 1 | a Terheyden, P.u University Medical Center Schleswig-Holstein4 aut |
| 700 | 1 | a Berger, A. C.u Thomas Jefferson University4 aut |
| 700 | 1 | a Huston, T. L.u Sunnybrook Health Sciences Centre4 aut |
| 700 | 1 | a Wayne, J. D.u Vanderbilt University4 aut |
| 700 | 1 | a Smithers, B. M.u Princess Alexandra Hospital4 aut |
| 700 | 1 | a Neuman, H. B.u Fox Chase Cancer Center4 aut |
| 700 | 1 | a Schneebaum, S.u Greenville Health System Cancer Center (GHS)4 aut |
| 700 | 1 | a Gershenwald, Jeffrey Eu Klinikum Nürnberg4 aut |
| 700 | 1 | a Ariyan, C. E.u Stony Brook University4 aut |
| 700 | 1 | a Desai, D. C.u St. Luke's University Health Network4 aut |
| 700 | 1 | a Jacobs, L. L.u Memorial Sloan-Kettering Cancer Center4 aut |
| 700 | 1 | a McMasters, K. M.u Roswell Park Cancer Institute4 aut |
| 700 | 1 | a Gesierich, A.u Northwestern University4 aut |
| 700 | 1 | a Hersey, Pu University of Wisconsin-Madison4 aut |
| 700 | 1 | a Bines, S. D.u Rush University Medical Center Chicago4 aut |
| 700 | 1 | a Kane, J. M.u Tel Aviv Sourasky Medical Center – Ichilov Hospital4 aut |
| 700 | 1 | a Barth, R. J.u Dartmouth-Hitchcock Medical Center4 aut |
| 700 | 1 | a McKinnon, G.u Johns Hopkins University School of Medicine4 aut |
| 700 | 1 | a Farma, J. M.u University of Louisville4 aut |
| 700 | 1 | a Schultz, E.u Hospital Clínic of Barcelona4 aut |
| 700 | 1 | a Vidal-Sicart, Sergiu Anderson Medical Center4 aut |
| 700 | 1 | a Hoefer, R. A.u Dartmouth-Hitchcock Medical Center4 aut |
| 700 | 1 | a Lewis, Melanie J.u Sentara CarePlex Hospital4 aut |
| 700 | 1 | a Scheri, R.u Newcastle Melanoma Unit4 aut |
| 700 | 1 | a Kelley, M. C.u Istituto Nazionale Tumori IRCCS - Fondazione G Pascale, Napoli4 aut |
| 700 | 1 | a Nieweg, Omgo E.u University of Sydney4 aut |
| 700 | 1 | a Noyes, R. D.u Huntsman Cancer Institute4 aut |
| 700 | 1 | a Hoon, Dave S. B.u Saint John's Health Center4 aut |
| 700 | 1 | a Wang, H. J.u University of California, Los Angeles4 aut |
| 700 | 1 | a Elashoff, D. A.u University of California, Los Angeles4 aut |
| 700 | 1 | a Elashoff, R. M.u University of California, Los Angeles4 aut |
| 710 | 2 | a Saint John's Health Centerb University of California, Los Angeles4 org |
| 773 | 0 | t New England Journal of Medicineg 376:23, s. 2211-2222q 376:23<2211-2222x 0028-4793 |
| 856 | 4 | u http://dx.doi.org/10.1056/NEJMoa1613210y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/770bbf34-e18f-4407-803a-7a3c439a7090 |
| 856 | 4 8 | u https://doi.org/10.1056/NEJMoa1613210 |
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