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Efficacy of copolym...
Efficacy of copolymer scaffolds delivering human demineralised dentine matrix for bone regeneration
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- Munir, Arooj (författare)
- Univ Bergen, Ctr Clin Dent Res, Dept Clin Dent, Fac Med, N-5009 Bergen, Norway.
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- Doskeland, Anne (författare)
- Univ Bergen, Dept Biomed, Bergen, Norway.
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- Avery, Steven J. (författare)
- Cardiff Univ, Dept Oral & Biomed Sci, Sch Dent, Cardiff, S Glam, Wales.;CITER, Cardiff, S Glam, Wales.
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- Fuoco, Tiziana, PhD, 1986- (författare)
- KTH,Fiber- och polymerteknologi
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- Mohamed-Ahmed, Samih (författare)
- Univ Bergen, Ctr Clin Dent Res, Dept Clin Dent, Fac Med, N-5009 Bergen, Norway.
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- Lygre, Henning (författare)
- Univ Bergen, Ctr Clin Dent Res, Dept Clin Dent, Fac Med, N-5009 Bergen, Norway.
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- Finne Wistrand, Anna, 1976- (författare)
- KTH,Fiber- och polymerteknologi,sDept Fibre & Polymer Technol, Stockholm, Sweden.
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- Sloan, Alastair J. (författare)
- Cardiff Univ, Dept Oral & Biomed Sci, Sch Dent, Cardiff, S Glam, Wales.;CITER, Cardiff, S Glam, Wales.
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- Waddington, Rachel J. (författare)
- Cardiff Univ, Dept Oral & Biomed Sci, Sch Dent, Cardiff, S Glam, Wales.;CITER, Cardiff, S Glam, Wales.
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- Mustafa, Kamal (författare)
- Univ Bergen, Ctr Clin Dent Res, Dept Clin Dent, Fac Med, N-5009 Bergen, Norway.
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- Suliman, Salwa (författare)
- Univ Bergen, Ctr Clin Dent Res, Dept Clin Dent, Fac Med, N-5009 Bergen, Norway.
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Univ Bergen, Ctr Clin Dent Res, Dept Clin Dent, Fac Med, N-5009 Bergen, Norway Univ Bergen, Dept Biomed, Bergen, Norway. (creator_code:org_t)
- 2019-05-31
- 2019
- Engelska.
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Ingår i: Journal of Tissue Engineering. - : SAGE PUBLICATIONS INC. - 2041-7314. ; 10
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Poly(L-lactide-co-epsilon-caprolactone) scaffolds were functionalised by 10 or 20 mu g/mL of human demineralised dentine matrix. Release kinetics up to 21 days and their osteogenic potential on human bone marrow stromal cells after 7 and 21 days were studied. A total of 390 proteins were identified by mass spectrometry. Bone regeneration proteins showed initial burst of release. Human bone marrow stromal cells were cultured on scaffolds physisorbed with 20 mu g/mL and cultured in basal medium (DDM group) or physisorbed and cultured in osteogenic medium or cultured on non-functionalised scaffolds in osteogenic medium. The human bone marrow stromal cells proliferated less in demineralised dentine matrix group and activated ERK/1/2 after both time points. Cells on DDM group showed highest expression of IL-6 and IL-8 at 7 days and expressed higher collagen type 1 alpha 2, SPP1 and bone morphogenetic protein-2 until 21 days. Extracellular protein revealed higher collagen type 1 and bone morphogenetic protein-2 at 21 days in demineralised dentine matrix group. Cells on DDM group showed signs of mineralisation. The functionalised scaffolds were able to stimulate osteogenic differentiation of human bone marrow stromal cells.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Growth factor
- mesenchymal stem cell
- bone tissue engineering
- drug delivery
- functionalisation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Munir, Arooj
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Doskeland, Anne
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Avery, Steven J.
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Fuoco, Tiziana, ...
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Mohamed-Ahmed, S ...
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Lygre, Henning
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visa fler...
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Finne Wistrand, ...
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Sloan, Alastair ...
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Waddington, Rach ...
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Mustafa, Kamal
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Suliman, Salwa
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