Targeted therapy for metastatic renal cell carcinoma

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Fältnamn	Indikatorer	Metadata
000		03278naa a2200361 4500
001		oai:DiVA.org:umu-176044
003		SwePub
008		201019s2020 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1760442 URI
024	7	a https://doi.org/10.1002/14651858.CD012796.pub22 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a for2 swepub-publicationtype
100	1	a Hofmann, Fabianu Umeå universitet,Urologi och andrologi4 aut
245	1 0	a Targeted therapy for metastatic renal cell carcinoma
264	1	b John Wiley & Sons,c 2020
338		a print2 rdacarrier
500		a Related publication: Hofmann F., Marconi L.S.O., Stewart F., Lam T.B.L., Bex A., Canfield S.E., Ljungberg B. Targeted therapy for metastatic renal cell carcinoma [Protocol - Intervention]. Cochrane Database of Systematic Reviews 2017, (9): CD012796. DOI:10.1002/14651858.CD012796
520		a Background: Several comparative randomised controlled trials (RCTs) have been performed including combinations of tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors since the publication of a Cochrane Review on targeted therapy for metastatic renal cell carcinoma (mRCC) in 2008. This review represents an update of that original review.Objectives: To assess the effects of targeted therapies for clear cell mRCC in patients naïve to systemic therapy.Search methods: We performed a comprehensive search with no restrictions on language or publication status. The date of the latest search was 18 June 2020.Selection criteria: We included randomised controlled trials, recruiting patients with clear cell mRCC naïve to previous systemic treatment. The index intervention was any TKI‐based targeted therapy.Data collection and analysis: Two review authors independently assessed the included studies and extracted data for the primary outcomes: progression‐free survival (PFS), overall survival (OS) and serious adverse events (SAEs); and the secondary outcomes: health‐related quality of life (QoL), response rate and minor adverse events (AEs). We performed statistical analyses using a random‐effects model and rated the certainty of evidence according to the GRADE approach.Main results: We included 18 RCTs reporting on 11,590 participants randomised across 18 comparisons. This abstract focuses on the primary outcomes of select comparisons.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
700	1	a Chang Hwang, E.4 aut
700	1	a Lam, Thomas B.L.4 aut
700	1	a Bex, Axel4 aut
700	1	a Yuan, Yuhong4 aut
700	1	a Marconi, Lorenzo S.O.4 aut
700	1	a Ljungberg, Börje,c Professor,d 1949-u Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)bolj0001
710	2	a Umeå universitetb Urologi och andrologi4 org
773	0	t Cochrane Database of Systematic Reviewsd : John Wiley & Sonsg :10q :10x 1469-493X
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-176044
856	4 8	u https://doi.org/10.1002/14651858.CD012796.pub2

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Av författaren/redakt...: Hofmann, Fabian; Chang Hwang, E.; Lam, Thomas B.L.; Bex, Axel; Yuan, Yuhong; Marconi, Lorenzo ...; visa fler...; Ljungberg, Börje ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Urologi och njur ...

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Av lärosätet: Umeå universitet

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