WFRF:(Lundberg Mikael)
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Safety evaluation of high-risk myocardial micro-biopsy in a swine model
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- Chireh, A. (author)
- Karolinska Institutet
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- Sandell, Mikael (author)
- KTH,Mikro- och nanosystemteknik,Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; MedTechLabs, Solna, Sweden
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- Grankvist, R. (author)
- Karolinska Institutet
- show more...
- Lövljung, V. (author)
- al-Saadi, J. (author)
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- (creator_code:org_t)
- 2021-11-23
- 2022
- English.
- In: Heart and Vessels. - : Springer Nature. - 0910-8327 .- 1615-2573. ; 37:4, s. 697-704
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The objective of the study was to investigate the safety profile of high-risk micro-endomyocardial biopsy (micro-EMB) compared to conventional EMB in a large animal model. Twenty pigs were subjected to a maximum of 30 consecutive biopsies, including sampling from the free ventricular wall, with either micro-EMB (n = 10) or conventional EMB (n = 10). There were no major complications in the micro-EMB group (0/10), compared to six major complications in the EMB group (6/10; p = 0.003). Survival analysis further highlighted these differences (p = 0.004). There were significantly higher volumes of pericardial effusion in the EMB group (p = 0.01). The study shows a safety advantage of micro-EMB compared to standard EMB in the experimental high-risk circumstances investigated in this animal study. These results indicate enhanced possibilities to collect samples from sensitive areas by using the micro-EMB technique instead of standard EMB.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Keyword
- Endomyocardial biopsy
- Interventional cardiology
- Micro-biopsy
- Safety
- adverse event
- animal
- biopsy
- cardiac muscle
- diagnostic imaging
- heart catheterization
- heart ventricle
- human
- pathology
- pericardial effusion
- pig
- procedures
- Animals
- Cardiac Catheterization
- Heart Ventricles
- Humans
- Myocardium
- Swine
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Chireh, A.
- Sandell, Mikael
- Grankvist, R.
- Lövljung, V.
- al-Saadi, J.
- Arnberg, F.
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- Lundberg, J.
- Settergren, M.
- Holmin, S.
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