WFRF:(Papadopoulos K. I.)
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04788naa a2200733 4500 | |
| 001 | oai:gup.ub.gu.se/266599 | |
| 003 | SwePub | |
| 008 | 240528s2018 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2665992 URI |
| 024 | 7 | a https://doi.org/10.1126/scitranslmed.aap87932 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Wang, Y.4 aut |
| 245 | 1 0 | a Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers |
| 264 | 1 | b American Association for the Advancement of Science (AAAS),c 2018 |
| 520 | a We report the detection of endometrial and ovarian cancers based on genetic analyses of DNA recovered from the fluids obtained during a routine Papanicolaou (Pap) test. The new test, called PapSEEK, incorporates assays for mutations in 18 genes as well as an assay for aneuploidy. In Pap brush samples from 382 endometrial cancer patients, 81% [95% confidence interval (CI), 77 to 85%] were positive, including 78% of patients with early-stage disease. The sensitivity in 245 ovarian cancer patients was 33% (95% CI, 27 to 39%), including 34% of patients with early-stage disease. In contrast, only 1.4% of 714 women without cancer had positive Pap brush samples (specificity, ~99%). Next, we showed that intrauterine sampling with a Tao brush increased the detection of malignancy over endocervical sampling with a Pap brush: 93% of 123 (95% CI, 87 to 97%) patients with endometrial cancer and 45% of 51 (95% CI, 31 to 60%) patients with ovarian cancer were positive, whereas none of the samples from 125 women without cancer were positive (specificity, 100%). Finally, in 83 ovarian cancer patients in whom plasma was available, circulating tumor DNA was found in 43% of patients (95% CI, 33 to 55%). When plasma and Pap brush samples were both tested, the sensitivity for ovarian cancer increased to 63% (95% CI, 51 to 73%). These results demonstrate the potential of mutation-based diagnostics to detect gynecologic cancers at a stage when they are more likely to be curable. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng |
| 700 | 1 | a Li, L.4 aut |
| 700 | 1 | a Douville, C.4 aut |
| 700 | 1 | a Cohen, J. D.4 aut |
| 700 | 1 | a Yen, T. T.4 aut |
| 700 | 1 | a Kinde, I.4 aut |
| 700 | 1 | a Sundfeldt, Karin,d 1962u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xsukar |
| 700 | 1 | a Kjær, S. K.4 aut |
| 700 | 1 | a Hruban, R. H.4 aut |
| 700 | 1 | a Shih, I. M.4 aut |
| 700 | 1 | a Wang, T. L.4 aut |
| 700 | 1 | a Kurman, R. J.4 aut |
| 700 | 1 | a Springer, S.4 aut |
| 700 | 1 | a Ptak, J.4 aut |
| 700 | 1 | a Popoli, M.4 aut |
| 700 | 1 | a Schaefer, J.4 aut |
| 700 | 1 | a Silliman, N.4 aut |
| 700 | 1 | a Dobbyn, L.4 aut |
| 700 | 1 | a Tanner, E. J.4 aut |
| 700 | 1 | a Angarita, A.4 aut |
| 700 | 1 | a Lycke, Mariau Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xlycma |
| 700 | 1 | a Jochumsen, K.4 aut |
| 700 | 1 | a Afsari, B.4 aut |
| 700 | 1 | a Danilova, L.4 aut |
| 700 | 1 | a Levine, D. A.4 aut |
| 700 | 1 | a Jardon, K.4 aut |
| 700 | 1 | a Zeng, X.4 aut |
| 700 | 1 | a Arseneau, J.4 aut |
| 700 | 1 | a Fu, L.4 aut |
| 700 | 1 | a Diaz, L. A.4 aut |
| 700 | 1 | a Karchin, R.4 aut |
| 700 | 1 | a Tomasetti, C.4 aut |
| 700 | 1 | a Kinzler, K. W.4 aut |
| 700 | 1 | a Vogelstein, B.4 aut |
| 700 | 1 | a Fader, A. N.4 aut |
| 700 | 1 | a Gilbert, L.4 aut |
| 700 | 1 | a Papadopoulos, N.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi4 org |
| 773 | 0 | t Science Translational Medicined : American Association for the Advancement of Science (AAAS)g 10:433, s. 1-9q 10:433<1-9x 1946-6234x 1946-6242 |
| 856 | 4 | u https://findresearcher.sdu.dk:8443/ws/files/151774636/eaap8793.full.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/266599 |
| 856 | 4 8 | u https://doi.org/10.1126/scitranslmed.aap8793 |
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- Wang, Y.
- Li, L.
- Douville, C.
- Cohen, J. D.
- Yen, T. T.
- Kinde, I.
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- Sundfeldt, Karin ...
- Kjær, S. K.
- Hruban, R. H.
- Shih, I. M.
- Wang, T. L.
- Kurman, R. J.
- Springer, S.
- Ptak, J.
- Popoli, M.
- Schaefer, J.
- Silliman, N.
- Dobbyn, L.
- Tanner, E. J.
- Angarita, A.
- Lycke, Maria
- Jochumsen, K.
- Afsari, B.
- Danilova, L.
- Levine, D. A.
- Jardon, K.
- Zeng, X.
- Arseneau, J.
- Fu, L.
- Diaz, L. A.
- Karchin, R.
- Tomasetti, C.
- Kinzler, K. W.
- Vogelstein, B.
- Fader, A. N.
- Gilbert, L.
- Papadopoulos, N.
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