SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Paul ES)
 

Sökning: WFRF:(Paul ES) > Analysis of FGGY as...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003442naa a2200493 4500
001oai:DiVA.org:umu-34689
003SwePub
008100611s2009 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-346892 URI
0247 a https://doi.org/10.3109/174829608026730422 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Van Es, Michael A4 aut
2451 0a Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis
264 c 2009-11-18
264 1b Informa UK Limited,c 2009
338 a print2 rdacarrier
520 a A genome-wide association study (GWAS) using pooled DNA samples from 386 sporadic ALS patients and 542 controls from the USA, identified genetic variation in FGGY (FLJ10986) as a risk factor, as well as 66 additional candidate SNPs. Considering the large number of hypotheses that are tested in GWAS, independent replication of associations is crucial for identifying true-positive genetic risk factors for disease. The primary aim of this study was to study the association between FGGY and sporadic ALS in large, homogeneous populations from northern Europe. Genotyping experiments were performed using Illumina Beadchips, Sequenom iPLEX assays and Taqman technology on large case-control series from The Netherlands, Belgium, Sweden and Ireland (total: 1883 sporadic ALS patients and 2063 controls). No significant association between sporadic ALS and the six previously reported associated SNPs in FGGY was observed: rs6700125 (p =0.56), rs6690993 (p =0.30), rs10493256 (p =0.68), rs6587852 (p =0.64), rs1470407 (p =0.28) and rs333662 (p =0.44). Screening of the additional candidate loci did not yield significant associations either, with the lowest p-value in joint analysis for rs7772593 (p =0.14). We concluded that common genetic variation in FGGY is not associated with susceptibility to sporadic ALS in genetically homogeneous populations from northern Europe.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
7001 a Van Vught, Paul W J4 aut
7001 a Veldink, Jan H4 aut
7001 a Andersen, Peter Mu Umeå universitet,Neurologi4 aut0 (Swepub:umu)pean0001
7001 a Birve, Annau Umeå universitet,Neurologi4 aut0 (Swepub:umu)anbi0001
7001 a Lemmens, Robin4 aut
7001 a Cronin, Simon4 aut
7001 a Van Der Kooi, Anneke J4 aut
7001 a De Visser, Marianne4 aut
7001 a Schelhaas, Helenius J4 aut
7001 a Hardiman, Orla4 aut
7001 a Ragoussis, Ioannis4 aut
7001 a Lambrechts, Diether4 aut
7001 a Robberecht, Wim4 aut
7001 a Wokke, John H J4 aut
7001 a Ophoff, Roel A4 aut
7001 a Van Den Berg, Leonard H4 aut
7102 a Umeå universitetb Neurologi4 org
7730 t Amyotrophic Lateral Sclerosis and other Motor Neuron Disordersd : Informa UK Limitedg 10:5-6, s. 441-447q 10:5-6<441-447x 1466-0822x 1743-4483
7730 t Amyotrophic Lateral Sclerosisd : Informa UK Limitedg 10:5-6, s. 441-447q 10:5-6<441-447x 1748-2968x 1471-180X
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-34689
8564 8u https://doi.org/10.3109/17482960802673042

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy