Meta-Analysis of Genome-Wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage.

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Fältnamn	Indikatorer	Metadata
000		06421naa a2201093 4500
001		oai:lup.lub.lu.se:884ab5d6-649a-45d8-a9a2-3dbb332eacce
003		SwePub
008		160404s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/43799142 URI
024	7	a https://doi.org/10.1016/j.ajhg.2014.02.0122 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Woo, Daniel4 aut
245	1 0	a Meta-Analysis of Genome-Wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage.
264	1	b Elsevier BV,c 2014
520		a Intracerebral hemorrhage (ICH) is the stroke subtype with the worst prognosis and has no established acute treatment. ICH is classified as lobar or nonlobar based on the location of ruptured blood vessels within the brain. These different locations also signal different underlying vascular pathologies. Heritability estimates indicate a substantial genetic contribution to risk of ICH in both locations. We report a genome-wide association study of this condition that meta-analyzed data from six studies that enrolled individuals of European ancestry. Case subjects were ascertained by neurologists blinded to genotype data and classified as lobar or nonlobar based on brain computed tomography. ICH-free control subjects were sampled from ambulatory clinics or random digit dialing. Replication of signals identified in the discovery cohort with p < 1 × 10(-6) was pursued in an independent multiethnic sample utilizing both direct and genome-wide genotyping. The discovery phase included a case cohort of 1,545 individuals (664 lobar and 881 nonlobar cases) and a control cohort of 1,481 individuals and identified two susceptibility loci: for lobar ICH, chromosomal region 12q21.1 (rs11179580, odds ratio [OR] = 1.56, p = 7.0 × 10(-8)); and for nonlobar ICH, chromosomal region 1q22 (rs2984613, OR = 1.44, p = 1.6 × 10(-8)). The replication included a case cohort of 1,681 individuals (484 lobar and 1,194 nonlobar cases) and a control cohort of 2,261 individuals and corroborated the association for 1q22 (p = 6.5 × 10(-4); meta-analysis p = 2.2 × 10(-10)) but not for 12q21.1 (p = 0.55; meta-analysis p = 2.6 × 10(-5)). These results demonstrate biological heterogeneity across ICH subtypes and highlight the importance of ascertaining ICH cases accordingly.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Falcone, Guido J4 aut
700	1	a Devan, William J4 aut
700	1	a Brown, W Mark4 aut
700	1	a Biffi, Alessandro4 aut
700	1	a Howard, Timothy D4 aut
700	1	a Anderson, Christopher D4 aut
700	1	a Brouwers, H Bart4 aut
700	1	a Valant, Valerie4 aut
700	1	a Battey, Thomas W K4 aut
700	1	a Radmanesh, Farid4 aut
700	1	a Raffeld, Miriam R4 aut
700	1	a Baedorf-Kassis, Sylvia4 aut
700	1	a Deka, Ranjan4 aut
700	1	a Woo, Jessica G4 aut
700	1	a Martin, Lisa J4 aut
700	1	a Haverbusch, Mary4 aut
700	1	a Moomaw, Charles J4 aut
700	1	a Sun, Guangyun4 aut
700	1	a Broderick, Joseph P4 aut
700	1	a Flaherty, Matthew L4 aut
700	1	a Martini, Sharyl R4 aut
700	1	a Kleindorfer, Dawn O4 aut
700	1	a Kissela, Brett4 aut
700	1	a Comeau, Mary E4 aut
700	1	a Jagiella, Jeremiasz M4 aut
700	1	a Schmidt, Helena4 aut
700	1	a Freudenberger, Paul4 aut
700	1	a Pichler, Alexander4 aut
700	1	a Enzinger, Christian4 aut
700	1	a Hansen, Björnu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-bhe
700	1	a Norrving, Bou Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-bno
700	1	a Jimenez-Conde, Jordi4 aut
700	1	a Giralt-Steinhauer, Eva4 aut
700	1	a Elosua, Roberto4 aut
700	1	a Cuadrado-Godia, Elisa4 aut
700	1	a Soriano, Carolina4 aut
700	1	a Roquer, Jaume4 aut
700	1	a Kraft, Peter4 aut
700	1	a Ayres, Alison M4 aut
700	1	a Schwab, Kristin4 aut
700	1	a McCauley, Jacob L4 aut
700	1	a Pera, Joanna4 aut
700	1	a Urbanik, Andrzej4 aut
700	1	a Rost, Natalia S4 aut
700	1	a Goldstein, Joshua N4 aut
700	1	a Viswanathan, Anand4 aut
700	1	a Stögerer, Eva-Maria4 aut
700	1	a Tirschwell, David L4 aut
700	1	a Selim, Magdy4 aut
700	1	a Brown, Devin L4 aut
700	1	a Silliman, Scott L4 aut
700	1	a Worrall, Bradford B4 aut
700	1	a Meschia, James F4 aut
700	1	a Kidwell, Chelsea S4 aut
700	1	a Montaner, Joan4 aut
700	1	a Fernandez-Cadenas, Israel4 aut
700	1	a Delgado, Pilar4 aut
700	1	a Malik, Rainer4 aut
700	1	a Dichgans, Martin4 aut
700	1	a Greenberg, Steven M4 aut
700	1	a Rothwell, Peter M4 aut
700	1	a Lindgren, Arneu Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)neur-ali
700	1	a Slowik, Agnieszka4 aut
700	1	a Schmidt, Reinhold4 aut
700	1	a Langefeld, Carl D4 aut
700	1	a Rosand, Jonathan4 aut
710	2	a Neurologi, Lundb Sektion IV4 org
773	0	t American Journal of Human Geneticsd : Elsevier BVg 94:4, s. 511-521q 94:4<511-521x 0002-9297
856	4	u http://www.ncbi.nlm.nih.gov/pubmed/24656865?dopt=Abstracty FULLTEXT
856	4	u http://dx.doi.org/10.1016/j.ajhg.2014.02.012y FULLTEXT
856	4	u http://www.cell.com/article/S0002929714000706/pdf
856	4 8	u https://lup.lub.lu.se/record/4379914
856	4 8	u https://doi.org/10.1016/j.ajhg.2014.02.012

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Av författaren/redakt...: Woo, Daniel; Falcone, Guido J; Devan, William J; Brown, W Mark; Biffi, Alessandr ...; Howard, Timothy ...; visa fler...; Anderson, Christ ...; Brouwers, H Bart; Valant, Valerie; Battey, Thomas W ...; Radmanesh, Farid; Raffeld, Miriam ...; Baedorf-Kassis, ...; Deka, Ranjan; Woo, Jessica G; Martin, Lisa J; Haverbusch, Mary; Moomaw, Charles ...; Sun, Guangyun; Broderick, Josep ...; Flaherty, Matthe ...; Martini, Sharyl ...; Kleindorfer, Daw ...; Kissela, Brett; Comeau, Mary E; Jagiella, Jeremi ...; Schmidt, Helena; Freudenberger, P ...; Pichler, Alexand ...; Enzinger, Christ ...; Hansen, Björn; Norrving, Bo; Jimenez-Conde, J ...; Giralt-Steinhaue ...; Elosua, Roberto; Cuadrado-Godia, ...; Soriano, Carolin ...; Roquer, Jaume; Kraft, Peter; Ayres, Alison M; Schwab, Kristin; McCauley, Jacob ...; Pera, Joanna; Urbanik, Andrzej; Rost, Natalia S; Goldstein, Joshu ...; Viswanathan, Ana ...; Stögerer, Eva-Ma ...; Tirschwell, Davi ...; Selim, Magdy; Brown, Devin L; Silliman, Scott ...; Worrall, Bradfor ...; Meschia, James F; Kidwell, Chelsea ...; Montaner, Joan; Fernandez-Cadena ...; Delgado, Pilar; Malik, Rainer; Dichgans, Martin; Greenberg, Steve ...; Rothwell, Peter ...; Lindgren, Arne; Slowik, Agnieszk ...; Schmidt, Reinhol ...; Langefeld, Carl ...; Rosand, Jonathan; visa färre...

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