Retinoids inhibit differentiation of hematopoietic osteoclast progenitors.

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Svensson Ulrika) > Retinoids inhibit d...

LIBRIS Formathandbok (Information om MARC21)

Details
MARC

Fältnamn	Indikatorer	Metadata
000		04635naa a2200769 4500
001		oai:gup.ub.gu.se/106067
003		SwePub
008		240528s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:umu-50657
009		oai:DiVA.org:umu-30072
024	7	a https://gup.ub.gu.se/publication/1060672 URI
024	7	a https://doi.org/10.1096/fj.09-1325482 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-506572 URI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-300722 URI
040		a (SwePub)gud (SwePub)umud (SwePub)umu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Conaway, H Herschel4 aut
245	1 0	a Retinoids inhibit differentiation of hematopoietic osteoclast progenitors.
264		c 2009-06-22
264	1	a Bethesda, Md.b Wiley,c 2009
520		a Whether vitamin A promotes skeletal fragility, has no effect on fracture rate, or protects against bone loss is unclear. In the present study, effects of retinoids on osteoclast differentiation in cultured mouse bone marrow cells (BMCs), bone marrow macrophages (BMMs), spleen cells, and RAW264.7 cells were evaluated by analyzing osteoclast formation and expression of genes important in signal transduction and osteoclast function. All-trans-retinoic acid (ATRA) did not stimulate osteoclastogenesis in BMCs, but inhibited hormone and RANKL-induced gene expression and formation of osteoclasts. In BMMs, spleen cells, and RAW264.7 cells, osteoclast differentiation and formation stimulated by M-CSF/RANKL were inhibited (IC(50) = 0.3 nM) by ATRA. The effect was exerted at an early step of RANKL-induced differentiation. ATRA also abolished increases of the transcription factors c-Fos and NFAT2 stimulated by RANKL and suppressed down-regulation of the antiosteoclastogenic transcription factor MafB. By comparing effects of several compounds structurally related to ATRA, as well as by using receptor antagonists, evaluation pointed to inhibition being mediated by RARalpha, with no involvement of PPARbeta/delta. The results suggest that activation of RARalpha by retinoids in myeloid hematopoietic precursor cells decreases osteoclast formation by altering expression of the transcription factors c-Fos, NFAT2, and MafB.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Odontologi0 (SwePub)302162 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Dentistry0 (SwePub)302162 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng
653		a Animals
653		a Cell Line
653		a Hematopoiesis
653		a drug effects
653		a Macrophages
653		a cytology
653		a drug effects
653		a physiology
653		a Mice
653		a Myeloid Progenitor Cells
653		a cytology
653		a drug effects
653		a physiology
653		a Osteoclasts
653		a cytology
653		a RANK Ligand
653		a metabolism
653		a Receptors
653		a Retinoic Acid
653		a agonists
653		a metabolism
653		a Signal Transduction
653		a drug effects
653		a Tretinoin
653		a pharmacology
653		a Animals
700	1	a Persson, Emmau Umeå universitet,Oral cellbiologi4 aut0 (Swepub:umu)empe0001
700	1	a Halén, Marieu Umeå universitet,Oral cellbiologi4 aut
700	1	a Granholm, Susanneu Umeå universitet,Oral cellbiologi4 aut0 (Swepub:umu)suegrm99
700	1	a Svensson, Olleu Umeå universitet,Ortopedi4 aut0 (Swepub:umu)olsv0001
700	1	a Pettersson, Ulrikau Umeå universitet,Klinisk farmakologi4 aut0 (Swepub:umu)ulpe0007
700	1	a Lie, Anitau Umeå universitet,Oral cellbiologi4 aut0 (Swepub:umu)anli0007
700	1	a Lerner, Ulf Hu Umeå universitet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine,Oral cellbiologi4 aut0 (Swepub:umu)ulle0001
710	2	a Umeå universitetb Oral cellbiologi4 org
773	0	t The FASEB journald Bethesda, Md. : Wileyg 23:10, s. 3526-38q 23:10<3526-38x 1530-6860x 0892-6638
856	4 8	u https://gup.ub.gu.se/publication/106067
856	4 8	u https://doi.org/10.1096/fj.09-132548
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-50657
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-30072

Find in a library

The FASEB journal (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Conaway, H Hersc ...; Persson, Emma; Halén, Marie; Granholm, Susann ...; Svensson, Olle; Pettersson, Ulri ...; show more...; Lie, Anita; Lerner, Ulf H; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Orthopaedics

Articles in the publication: The FASEB journa ...

By the university: University of Gothenburg; Umeå University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se