WFRF:(Thanh Duc Nguyen)
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- Hien Tran, ThiLund University,Lunds universitet,Molekylär kärlfysiologi,Forskargrupper vid Lunds universitet,Molecular Vascular Physiology,Lund University Research Groups,Thai Binh University of Medicine and Pharmacy (author)
Triolein from Coix lacryma-jobi induces cell cycle arrest through p53/p21 signaling pathway
- Article/chapterEnglish2016
Publisher, publication year, extent ...
- 2016-08-21
- Oriental Scientific Publishing Company,2016
- 6 s.
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:8573a1d9-9672-4336-a183-50a05fb95e0e
- https://lup.lub.lu.se/record/8573a1d9-9672-4336-a183-50a05fb95e0eURI
- https://doi.org/10.13005/bpj/967DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- p53, a tumor suppressor protein, has important roles in DNA repair, cell cycle and apoptosis, is a one of the key events in cancer development. Coix lacryma-jobi seed has been used as a food and traditional medicine plant with anti-oxidant, anti-cancer and anti-diabetic effects. In currently research, we identified the most potent p53-increasing compound among 4 compounds (1-4) found in Coix lacryma-jobi and demonstrated its molecular mechanism in MCF-7 cells. Among the four isolated compounds (1-4), triolein most increased p53. Triolein treatment induced p53, p21, p27 and Bax in MCF-7 cells. Moreover, triolein caused S phase arrest through suppression of CDK1, phopho-Rb and E2F1 in dose-dependent manner. We also observed the decreasing of DNA synthesis by triolein. These data suggest that triolein may induced cell cycle restart involve DNA synthesis and apoptosis pathway in MCF-7 cells.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
- Apoptosis
- Coix lacryma-jobi
- DNA synthesis
- MCF-7 cells
- Triolein
Added entries (persons, corporate bodies, meetings, titles ...)
- Ha, Do ThiNational Institute of Medicinal Materials, Vietnam (author)
- Truong, Do MinhThai Nguyen University (author)
- Duc, Loi VuVietnam National University (author)
- Dao, Trong TuanNational Institute of Medicinal Materials, Vietnam (author)
- Binh, Bui ThiThai Binh University of Medicine and Pharmacy (author)
- Hai, Nguyen ThanhVietnam National University (author)
- Molekylär kärlfysiologiForskargrupper vid Lunds universitet (creator_code:org_t)
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- In:Biomedical and Pharmacology Journal: Oriental Scientific Publishing Company9:2, s. 519-5240974-6242
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