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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005894naa a2200685 4500
001oai:lup.lub.lu.se:6ac1570e-7d49-4c73-8385-6cb99677a20a
003SwePub
008200103s2020 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/6ac1570e-7d49-4c73-8385-6cb99677a20a2 URI
0247 a https://doi.org/10.2337/dc19-08802 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Battaglia, Manuelau San Raffaele Hospital,San Raffaele Scientific Institute4 aut
2451 0a Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes
264 c 2019-12-12
264 1b American Diabetes Association,c 2020
300 a 8 s.
520 a The clinical diagnosis of new-onset type 1 diabetes has, for many years, been considered relatively straightforward. Recently, however, there is increasing awareness that within this single clinical phenotype exists considerable heterogeneity: disease onset spans the complete age range; genetic susceptibility is complex; rates of progression differ markedly, as does insulin secretory capacity; and complication rates, glycemic control, and therapeutic intervention efficacy vary widely. Mechanistic and immunopathological studies typically show considerable patchiness across subjects, undermining conclusions regarding disease pathways. Without better understanding, type 1 diabetes heterogeneity represents a major barrier both to deciphering pathogenesis and to the translational effort of designing, conducting, and interpreting clinical trials of disease-modifying agents. This realization comes during a period of unprecedented change in clinical medicine, with increasing emphasis on greater individualization and precision. For complex disorders such as type 1 diabetes, the option of maintaining the "single disease" approach appears untenable, as does the notion of individualizing each single patient's care, obliging us to conceptualize type 1 diabetes less in terms of phenotypes (observable characteristics) and more in terms of disease endotypes (underlying biological mechanisms). Here, we provide our view on an approach to dissect heterogeneity in type 1 diabetes. Using lessons from other diseases and the data gathered to date, we aim to delineate a roadmap through which the field can incorporate the endotype concept into laboratory and clinical practice. We predict that such an effort will accelerate the implementation of precision medicine and has the potential for impact on our approach to translational research, trial design, and clinical management.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Ahmed, Simiu Juvenile Diabetes Research Foundation4 aut
7001 a Anderson, Mark S.u University of California, San Francisco4 aut
7001 a Atkinson, Mark A.u University of Florida4 aut
7001 a Becker, Dorothyu Children's Hospital of Pittsburgh of UPMC4 aut
7001 a Bingley, Polly J.u University of Bristol4 aut
7001 a Bosi, Emanueleu San Raffaele Hospital,Vita-Salute San Raffaele University4 aut
7001 a Brusko, Todd M.u University of Florida4 aut
7001 a DiMeglio, Linda A.u Indiana University4 aut
7001 a Evans-Molina, Carmellau Indiana University4 aut
7001 a Gitelman, Stephen E.u University of California, San Francisco4 aut
7001 a Greenbaum, Carla J.u Benaroya Research Institute4 aut
7001 a Gottlieb, Peter A.u University of Colorado4 aut
7001 a Herold, Kevan C.u Yale University4 aut
7001 a Hessner, Martin J.u Medical College of Wisconsin4 aut
7001 a Knip, Mikaelu Helsinki University Children's Hospital,University of Helsinki4 aut
7001 a Jacobsen, Laurau University of Florida4 aut
7001 a Krischer, Jeffrey P.u University of South Florida4 aut
7001 a Long, S. Aliceu Benaroya Research Institute4 aut
7001 a Lundgren, Markusu Lund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-mn2
7001 a McKinney, Eoin F.u Addenbrooke's Hospital,University of Cambridge4 aut
7001 a Morgan, Noel G.u University of Exeter,Royal Devon & Exeter Hospital4 aut
7001 a Oram, Richard A.u University of Exeter,Royal Devon & Exeter Hospital4 aut
7001 a Pastinen, Tomiu Children's Mercy Hospitals and Clinics, Kansas City4 aut
7001 a Peters, Michael C.u University of California, San Francisco4 aut
7001 a Petrelli, Alessandrau San Raffaele Hospital,San Raffaele Scientific Institute4 aut
7001 a Qian, Xiaoningu Texas A and M University4 aut
7001 a Redondo, Maria J.u Texas Children’s Hospital,Baylor College of Medicine4 aut
7001 a Roep, Bart O.u Leiden University Medical Centre,City of Hope National Medical Center4 aut
7001 a Schatz, Desmondu University of Florida4 aut
7001 a Skibinski, Davidu Benaroya Research Institute4 aut
7001 a Peakman, Marku King's Health Partners,King's College London4 aut
7102 a San Raffaele Hospitalb San Raffaele Scientific Institute4 org
7730 t Diabetes Cared : American Diabetes Associationg 43:1, s. 5-12q 43:1<5-12x 1935-5548x 0149-5992
8564 u http://dx.doi.org/10.2337/dc19-0880y FULLTEXT
8564 u https://care.diabetesjournals.org/content/diacare/43/1/5.full.pdf
8564 8u https://lup.lub.lu.se/record/6ac1570e-7d49-4c73-8385-6cb99677a20a
8564 8u https://doi.org/10.2337/dc19-0880

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