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Mapping the synthes...
Mapping the synthesis and the impact of low molecular weight PLGA-g-PEG on sol-gel properties to design hierarchical porous scaffolds
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- Fagerland, Jenny (författare)
- KTH,Polymerteknologi
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- Finne-Wistrand, Anna (författare)
- KTH,Polymerteknologi
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(creator_code:org_t)
- 2013-12-24
- 2013
- Engelska.
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Ingår i: Journal of polymer research. - : Springer Science and Business Media LLC. - 1022-9760 .- 1572-8935. ; 21:1, s. 337-
- Relaterad länk:
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https://urn.kb.se/re...
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visa fler...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Bone morphogenetic protein 2 (BMP-2)-functionalized poly(l-lactide-co-epsilon-caprolactone) (PLCL) porous scaffolds have shown promising results in bone tissue regeneration studies. It is believed that even better results are achieved by hierarchical porous scaffolds and a designed sequential release of growth factors. We therefore synthesized (l-lactide-co-glycolide)-g-poly(ethylene glycol) (PLGA-g-PEG) oligomers which could be injected into PLCL porous scaffolds. They were synthesized by ring-opening polymerization and carefully characterized by nuclear magnetic resonance spectroscopy (NMR), matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS), and size exclusion chromatography (SEC). The sol-gel transition temperature, pH, and functional life were determined and correlated with the molecular structure of PLGA-g-PEG. We found that low molecular weight PLGA-g-PEG was obtained and poly(l-lactide-co-glycolide-co-poly(ethylene glycol) methyl ether) (PLGA-MPEG) appeared to contribute to gelation. It was possible to design a system that formed a hydrogel within 1 min at 37 A degrees C with a pH between 6 and 7 and with a functional life of around 1 month. These low molecular weight thermosensitive PLGA-g-PEG oligomers, which can be injected into PLCL scaffolds, appear promising for bone tissue engineering applications.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik -- Polymerteknologi (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering -- Polymer Technologies (hsv//eng)
Nyckelord
- Thermosensitive gel
- PLGA-g-PEG
- Porous scaffolds
- Tissue engineering
- Degradable polymers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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