Therapeutic potential of an anaerobic cultured human intestinal microbiota, ACHIM, for treatment of IBS

Benno, P. (författare): Uppsala universitet,Institutionen för medicinska vetenskaper,Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden

Norin, E. (författare): Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden

Midtvedt, T. (författare): Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden

Hellström, Per M., 1954- (författare): Uppsala universitet,Gastroenterologi/hepatologi

(creator_code:org_t)

Elsevier, 2019
2019
Engelska.
Ingår i: Baillière's Best Practice & Research. - : Elsevier. - 1521-6918 .- 1532-1916. ; 40-41

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.1...; http://kipublication...; visa färre...

Abstract Ämnesord

Stäng

By administering an anaerobic cultivated human intestinal microbiota (ACHIM) via upper gastrointestinal route using endoscopy we aimed to rectify intestinal dysbiosis and simultaneously achieve a treatment response in IBS patients. The study population fulfilled the Rome III IBS criteria and comprised 50 patients. During 10 days, patients recorded the irritable bowel syndrome symptom severity scale (IBS-SSS) along with the Bristol stool scale and number of stools/day. The enrolled patients were categorized as follows: 37 with diarrhea, 5 with constipation and 8 with mixed symptoms. The treatment response showed reduction in a majority of patients, 32 of which with 50-point reduction of IBS-SSS and 21 with a 100-point IBS-SSS reduction. The percentage improvement was 36 (23-49) and 28 (18-38) for women and men respectively. Short-chain fatty acids were not changed. We consider fecal microbiota transplantation in the form of ACHIM as an option for the future therapeutic armamentarium in IBS. (C) 2019 Published by Elsevier Ltd.

Av författaren/redakt...: Benno, P.; Norin, E.; Midtvedt, T.; Hellström, Per M ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.