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Analysis of TAP2 an...
Analysis of TAP2 and HLA-DP gene polymorphism in psoriasis
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Fakler, JW (författare)
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- Schmitt-Egenolf, Marcus (författare)
- Department of Dermatology, University of Ulm, Ulm, Germany
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Vejbaesya, S (författare)
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Boehncke, WH (författare)
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Sterry, W (författare)
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Eiermann, TH (författare)
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(creator_code:org_t)
- Elsevier BV, 1994
- 1994
- Engelska.
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Ingår i: Human Immunology. - : Elsevier BV. - 0198-8859 .- 1879-1166. ; 40:4, s. 299-302
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- TAP2 is a gene, located between HLA-DP and HLA-DQ, whose products form a transporter molecule involved in endogenous antigen processing. Polymorphic residues have been described in this gene. TAP2 is of particular interest because its involvement in antigen presentation makes it a candidate for a disease susceptibility gene. In psoriasis, two clinical subtypes analogous to the situation in diabetes type I with early onset and family history and type II with later onset and without family history have been described. We have previously shown that type I but not type II psoriasis is associated with the HLA-DRB1*0701/2, -DQA1*0201, -DQB1*0303 haplotype. To investigate whether this haplotype extends to include particular TAP2 and/or DP alleles, we tested the TAP2 and HLA-DP alleles of a control group (n = 199), patients with psoriasis type I (n = 66), and patients with psoriasis type II (n = 35) by hybridization with SSOs. Our data show that there is no significant correlation between TAP2 and/or HLA-DP gene polymorphism and psoriasis type I and/or type II. We conclude that disease association in type I psoriasis is associated with the extended haplotype HLA-B57, -Cw6, -DRB1*0701/2, -DQA1*0201, -DQB1*0303.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Nyckelord
- mhc class-ii; major histocompatibility complex; oligonucleotide probes; langerhans cells; antigen; transporter; molecules; dna; expression; autoimmunity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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