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  • Lang, ChristianMedical University of Vienna (författare)

C-Myc protein expression indicates unfavorable clinical outcome in surgically resected small cell lung cancer

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • 2024

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:ed4926e4-3f41-4708-9ac2-7fe0287dceaf
  • https://lup.lub.lu.se/record/ed4926e4-3f41-4708-9ac2-7fe0287dceafURI
  • https://doi.org/10.1186/s12957-024-03315-7DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background: By being highly involved in the tumor evolution and disease progression of small cell lung cancer (SCLC), Myc family members (C-Myc, L-Myc, and N-Myc) might represent promising targetable molecules. Our aim was to investigate the expression pattern and prognostic relevance of these oncogenic proteins in an international cohort of surgically resected SCLC tumors. Methods: Clinicopathological data and surgically resected tissue specimens from 104 SCLC patients were collected from two collaborating European institutes. Tissue sections were stained by immunohistochemistry (IHC) for all three Myc family members and the recently introduced SCLC molecular subtype-markers (ASCL1, NEUROD1, POU2F3, and YAP1). Results: IHC analysis showed C-Myc, L-Myc, and N-Myc positivity in 48%, 63%, and 9% of the specimens, respectively. N-Myc positivity significantly correlated with the POU2F3-defined molecular subtype (r = 0.6913, p = 0.0056). SCLC patients with C-Myc positive tumors exhibited significantly worse overall survival (OS) (20 vs. 44 months compared to those with C-Myc negative tumors, p = 0.0176). Ultimately, in a multivariate risk model adjusted for clinicopathological and treatment confounders, positive C-Myc expression was confirmed as an independent prognosticator of impaired OS (HR 1.811, CI 95% 1.054–3.113, p = 0.032). Conclusions: Our study provides insights into the clinical aspects of Myc family members in surgically resected SCLC tumors. Notably, besides showing that positivity of Myc family members varies across the patients, we also reveal that C-Myc protein expression independently correlates with worse survival outcomes. Further studies are warranted to investigate the role of Myc family members as potential prognostic and predictive markers in this hard-to-treat disease.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Megyesfalvi, ZsoltNational Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna,National Institute of Oncology, Budapest (författare)
  • Lantos, AndrasNational Korányi Institute for Tuberculosis and Pulmonology, Hungary (författare)
  • Oberndorfer, FelicitasMedical University of Vienna (författare)
  • Hoda, Mir AlirezaMedical University of Vienna (författare)
  • Solta, AnnaMedical University of Vienna (författare)
  • Ferencz, BenceNational Korányi Institute for Tuberculosis and Pulmonology, Hungary,National Institute of Oncology, Budapest (författare)
  • Fillinger, JanosNational Korányi Institute for Tuberculosis and Pulmonology, Hungary (författare)
  • Solyom-Tisza, AnnaNational Korányi Institute for Tuberculosis and Pulmonology, Hungary (författare)
  • Querner, Alessandro SaeedMedical University of Vienna (författare)
  • Egger, FelixMedical University of Vienna (författare)
  • Boettiger, KristiinaMedical University of Vienna (författare)
  • Klikovits, ThomasClinic Floridsdorf (författare)
  • Timelthaler, GeraldMedical University of Vienna (författare)
  • Renyi-Vamos, FerencNational Korányi Institute for Tuberculosis and Pulmonology, Hungary,National Institute of Oncology, Budapest (författare)
  • Aigner, ClemensMedical University of Vienna (författare)
  • Hoetzenecker, KonradMedical University of Vienna (författare)
  • Laszlo, ViktoriaNational Institute of Oncology, Budapest,Medical University of Vienna,National Korányi Institute for Tuberculosis and Pulmonology, Hungary (författare)
  • Schelch, KarinMedical University of Vienna (författare)
  • Dome, BalazsLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,Semmelweis University,Medical University of Vienna,National Korányi Institute for Tuberculosis and Pulmonology, Hungary(Swepub:lu)ba1464do (författare)
  • Medical University of ViennaNational Korányi Institute for Tuberculosis and Pulmonology, Hungary (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:World Journal of Surgical Oncology22:11477-7819

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