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Sökning: WFRF:(Aigner Clemens) > C-Myc protein expre...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005363naa a2200553 4500
001oai:lup.lub.lu.se:ed4926e4-3f41-4708-9ac2-7fe0287dceaf
003SwePub
008240313s2024 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/ed4926e4-3f41-4708-9ac2-7fe0287dceaf2 URI
0247 a https://doi.org/10.1186/s12957-024-03315-72 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Lang, Christianu Medical University of Vienna4 aut
2451 0a C-Myc protein expression indicates unfavorable clinical outcome in surgically resected small cell lung cancer
264 1c 2024
520 a Background: By being highly involved in the tumor evolution and disease progression of small cell lung cancer (SCLC), Myc family members (C-Myc, L-Myc, and N-Myc) might represent promising targetable molecules. Our aim was to investigate the expression pattern and prognostic relevance of these oncogenic proteins in an international cohort of surgically resected SCLC tumors. Methods: Clinicopathological data and surgically resected tissue specimens from 104 SCLC patients were collected from two collaborating European institutes. Tissue sections were stained by immunohistochemistry (IHC) for all three Myc family members and the recently introduced SCLC molecular subtype-markers (ASCL1, NEUROD1, POU2F3, and YAP1). Results: IHC analysis showed C-Myc, L-Myc, and N-Myc positivity in 48%, 63%, and 9% of the specimens, respectively. N-Myc positivity significantly correlated with the POU2F3-defined molecular subtype (r = 0.6913, p = 0.0056). SCLC patients with C-Myc positive tumors exhibited significantly worse overall survival (OS) (20 vs. 44 months compared to those with C-Myc negative tumors, p = 0.0176). Ultimately, in a multivariate risk model adjusted for clinicopathological and treatment confounders, positive C-Myc expression was confirmed as an independent prognosticator of impaired OS (HR 1.811, CI 95% 1.054–3.113, p = 0.032). Conclusions: Our study provides insights into the clinical aspects of Myc family members in surgically resected SCLC tumors. Notably, besides showing that positivity of Myc family members varies across the patients, we also reveal that C-Myc protein expression independently correlates with worse survival outcomes. Further studies are warranted to investigate the role of Myc family members as potential prognostic and predictive markers in this hard-to-treat disease.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Immunohistochemistry
653 a Molecular subtypes
653 a Myc family
653 a Small cell lung cancer
7001 a Megyesfalvi, Zsoltu National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna,National Institute of Oncology, Budapest4 aut
7001 a Lantos, Andrasu National Korányi Institute for Tuberculosis and Pulmonology, Hungary4 aut
7001 a Oberndorfer, Felicitasu Medical University of Vienna4 aut
7001 a Hoda, Mir Alirezau Medical University of Vienna4 aut
7001 a Solta, Annau Medical University of Vienna4 aut
7001 a Ferencz, Benceu National Korányi Institute for Tuberculosis and Pulmonology, Hungary,National Institute of Oncology, Budapest4 aut
7001 a Fillinger, Janosu National Korányi Institute for Tuberculosis and Pulmonology, Hungary4 aut
7001 a Solyom-Tisza, Annau National Korányi Institute for Tuberculosis and Pulmonology, Hungary4 aut
7001 a Querner, Alessandro Saeedu Medical University of Vienna4 aut
7001 a Egger, Felixu Medical University of Vienna4 aut
7001 a Boettiger, Kristiinau Medical University of Vienna4 aut
7001 a Klikovits, Thomasu Clinic Floridsdorf4 aut
7001 a Timelthaler, Geraldu Medical University of Vienna4 aut
7001 a Renyi-Vamos, Ferencu National Korányi Institute for Tuberculosis and Pulmonology, Hungary,National Institute of Oncology, Budapest4 aut
7001 a Aigner, Clemensu Medical University of Vienna4 aut
7001 a Hoetzenecker, Konradu Medical University of Vienna4 aut
7001 a Laszlo, Viktoriau National Institute of Oncology, Budapest,Medical University of Vienna,National Korányi Institute for Tuberculosis and Pulmonology, Hungary4 aut
7001 a Schelch, Karinu Medical University of Vienna4 aut
7001 a Dome, Balazsu Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,Semmelweis University,Medical University of Vienna,National Korányi Institute for Tuberculosis and Pulmonology, Hungary4 aut0 (Swepub:lu)ba1464do
7102 a Medical University of Viennab National Korányi Institute for Tuberculosis and Pulmonology, Hungary4 org
7730 t World Journal of Surgical Oncologyg 22:1q 22:1x 1477-7819
8564 u http://dx.doi.org/10.1186/s12957-024-03315-7x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/ed4926e4-3f41-4708-9ac2-7fe0287dceaf
8564 8u https://doi.org/10.1186/s12957-024-03315-7

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