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  • Schnieders, R (author)

1H, 13C and 15N chemical shift assignment of the stem-loop 5a from the 5'-UTR of SARS-CoV-2

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-01-23
  • Springer Science and Business Media LLC,2021

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:145712860
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:145712860URI
  • https://doi.org/10.1007/s12104-021-10007-wDOI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The SARS-CoV-2 (SCoV-2) virus is the causative agent of the ongoing COVID-19 pandemic. It contains a positive sense single-stranded RNA genome and belongs to the genus of Betacoronaviruses. The 5′- and 3′-genomic ends of the 30 kb SCoV-2 genome are potential antiviral drug targets. Major parts of these sequences are highly conserved among Betacoronaviruses and contain cis-acting RNA elements that affect RNA translation and replication. The 31 nucleotide (nt) long highly conserved stem-loop 5a (SL5a) is located within the 5′-untranslated region (5′-UTR) important for viral replication. SL5a features a U-rich asymmetric bulge and is capped with a 5′-UUUCGU-3′ hexaloop, which is also found in stem-loop 5b (SL5b). We herein report the extensive 1H, 13C and 15N resonance assignment of SL5a as basis for in-depth structural studies by solution NMR spectroscopy.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Peter, SA (author)
  • Banijamali, E (author)
  • Riad, M (author)
  • Altincekic, N (author)
  • Bains, JK (author)
  • Ceylan, B (author)
  • Furtig, B (author)
  • Grun, JT (author)
  • Hengesbach, M (author)
  • Hohmann, KF (author)
  • Hymon, D (author)
  • Knezic, B (author)
  • Oxenfarth, A (author)
  • Petzold, KKarolinska Institutet (author)
  • Qureshi, NS (author)
  • Richter, C (author)
  • Schlagnitweit, J (author)
  • Schlundt, A (author)
  • Schwalbe, H (author)
  • Stirnal, E (author)
  • Sudakov, A (author)
  • Vogele, J (author)
  • Wacker, A (author)
  • Weigand, JE (author)
  • Wirmer-Bartoschek, J (author)
  • Wohnert, J (author)
  • Karolinska Institutet (creator_code:org_t)

Related titles

  • In:Biomolecular NMR assignments: Springer Science and Business Media LLC15:1, s. 203-2111874-270X1874-2718

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