Effect of chronic mild stress on skin and brain in the NC/Nga atopic-like mouse

Nordlind, Klas (författare): Department of Medicine, Solna, Dermatology and Venereology Unit, Karolinska Institutet, Stockholm

Lonne-Rahm, S-B (författare): Department of Medicine, Solna, Dermatology and Venereology Unit, Karolinska Institutet, Stockholm

El-Nour, H (författare): Department of Medicine, Solna, Dermatology and Venereology Unit, Karolinska Institutet, Stockholm

Rasul, A (författare): Department of Medicine, Solna, Dermatology and Venereology Unit, Karolinska Institutet, Stockholm

Grip, L (författare): Department of Medicine, Solna, Dermatology and Venereology Unit, Karolinska Institutet, Stockholm

Holst, M (författare): Department of Woman and Child Health, Astrid Lindgren Children’s Hospital, Solna, Stockholm

Johansson, B (författare): Departments of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm

Olson, L (författare): Department of Neuroscience, Karolinska Institutet, Stockholm

Theodorsson, Elvar (författare): Östergötlands Läns Landsting,Linköpings universitet,Klinisk kemi,Hälsouniversitetet

Blakely, R D (författare): Department of Pharmacology and Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, TN, USA

(creator_code:org_t)

Nature Publishing Group, 2011
2011
Engelska.
Ingår i: JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol 131 Issue S2 (September 2011). - : Nature Publishing Group. ; , s. S116-S116

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Abstract Ämnesord

Stäng

Atopic eczema is often worsened by stress. We have studied the effect of chronic mild stress in the atopic-like NC/Nga mouse strain. The mice were subjected to chronic mild stress for 12 weeks and eczema was induced by applying a mite antigen (Dermatophagoides pteronyssinus) on the ears for the last 4 weeks. The mice were divided into stressed eczematous, non-stressed eczematousand stressed control groups. Serum corticosterone levels were determined at the endpoint of the experiment. The biopsies from skin and brain have been analyzed using immunohistochemistry and RT-PCR. The diameter of the ears was larger in the stressed eczematous group compared to the other groups. Moreover, the corticosterone levels were significantly lower in the stressedeczematous group. The neuromediators being studied are serotonin, its transporter protein, as well as its receptors, and the tachykinin substance P and its receptor neurokinin-1.

Av författaren/redakt...: Nordlind, Klas; Lonne-Rahm, S-B; El-Nour, H; Rasul, A; Grip, L; Holst, M; visa fler...; Johansson, B; Olson, L; Theodorsson, Elv ...; Blakely, R D; visa färre...

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