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Effect of chronic mild stress on skin and brain in the NC/Nga atopic-like mouse
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- Nordlind, Klas (author)
- Department of Medicine, Solna, Dermatology and Venereology Unit, Karolinska Institutet, Stockholm
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- Lonne-Rahm, S-B (author)
- Department of Medicine, Solna, Dermatology and Venereology Unit, Karolinska Institutet, Stockholm
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- El-Nour, H (author)
- Department of Medicine, Solna, Dermatology and Venereology Unit, Karolinska Institutet, Stockholm
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- (creator_code:org_t)
- Nature Publishing Group, 2011
- 2011
- English.
- In: JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol 131 Issue S2 (September 2011). - : Nature Publishing Group. ; , s. S116-S116
- Conference paper (peer-reviewed)
Abstract
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- Atopic eczema is often worsened by stress. We have studied the effect of chronic mild stress in the atopic-like NC/Nga mouse strain. The mice were subjected to chronic mild stress for 12 weeks and eczema was induced by applying a mite antigen (Dermatophagoides pteronyssinus) on the ears for the last 4 weeks. The mice were divided into stressed eczematous, non-stressed eczematousand stressed control groups. Serum corticosterone levels were determined at the endpoint of the experiment. The biopsies from skin and brain have been analyzed using immunohistochemistry and RT-PCR. The diameter of the ears was larger in the stressed eczematous group compared to the other groups. Moreover, the corticosterone levels were significantly lower in the stressedeczematous group. The neuromediators being studied are serotonin, its transporter protein, as well as its receptors, and the tachykinin substance P and its receptor neurokinin-1.
Keyword
- TECHNOLOGY
- TEKNIKVETENSKAP
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- kon (subject category)
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- JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol 131 Issue S2 (September 2011) (Search for host publication in LIBRIS)
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- Lonne-Rahm, S-B
- El-Nour, H
- Rasul, A
- Grip, L
- Holst, M
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- Johansson, B
- Olson, L
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- Blakely, R D
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