Search: WFRF:(Buys Emmanuel S.) >
The Antarctic Wedde...
The Antarctic Weddell seal genome reveals evidence of selection on cardiovascular phenotype and lipid handling
-
- Noh, Hyun Ji (author)
- Broad Inst MIT & Harvard, 7 Cambridge Ctr, Cambridge, MA 02142 USA.
-
- Turner-Maier, Jason (author)
- Broad Inst MIT & Harvard, 7 Cambridge Ctr, Cambridge, MA 02142 USA.
-
- Schulberg, S. Anne (author)
- Harvard Med Sch, Anesthesia Ctr Crit Care Res, Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, 55 Fruit St, Boston, MA 02114 USA.
-
show more...
-
- Fitzgerald, Michael L. (author)
- Harvard Med Sch, Ctr Computat & Integrat Biol, Massachusetts Gen Hosp, Lipid Metab Unit, 55 Fruit St, Boston, MA 02114 USA.
-
- Johnson, Jeremy (author)
- Broad Inst MIT & Harvard, 7 Cambridge Ctr, Cambridge, MA 02142 USA.
-
- Allen, Kaitlin N. (author)
- Harvard Med Sch, Anesthesia Ctr Crit Care Res, Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, 55 Fruit St, Boston, MA 02114 USA.
-
- Huckstadt, Luis A. (author)
- Univ Calif Santa Cruz, Inst Marine Sci, Dept Ecol & Evolutionary Biol, 130 McAllister Way, Santa Cruz, CA 95060 USA.
-
- Batten, Annabelle J. (author)
- Harvard Med Sch, Anesthesia Ctr Crit Care Res, Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, 55 Fruit St, Boston, MA 02114 USA.
-
- Alfoldi, Jessica (author)
- Broad Inst MIT & Harvard, 7 Cambridge Ctr, Cambridge, MA 02142 USA.
-
- Costa, Daniel P. (author)
- Univ Calif Santa Cruz, Inst Marine Sci, Dept Ecol & Evolutionary Biol, 130 McAllister Way, Santa Cruz, CA 95060 USA.
-
- Karlsson, Elinor K. (author)
- Broad Inst MIT & Harvard, 7 Cambridge Ctr, Cambridge, MA 02142 USA.;Univ Massachusetts, Program Bioinformat & Integrat Biol, Med Sch, Worcester, MA 01655 USA.
-
- Zapol, Warren M. (author)
- Harvard Med Sch, Anesthesia Ctr Crit Care Res, Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, 55 Fruit St, Boston, MA 02114 USA.
-
- Buys, Emmanuel S. (author)
- Broad Inst MIT & Harvard, 7 Cambridge Ctr, Cambridge, MA 02142 USA.;Harvard Med Sch, Anesthesia Ctr Crit Care Res, Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, 55 Fruit St, Boston, MA 02114 USA.
-
- Lindblad-Toh, Kerstin (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Broad Inst MIT & Harvard, 7 Cambridge Ctr, Cambridge, MA 02142 USA
-
- Hindle, Allyson G. (author)
- Broad Inst MIT & Harvard, 7 Cambridge Ctr, Cambridge, MA 02142 USA.;Harvard Med Sch, Anesthesia Ctr Crit Care Res, Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, 55 Fruit St, Boston, MA 02114 USA.;Univ Nevada, Sch Life Sci, 4505S Maryland Pkwy, Las Vegas, NV 89154 USA.
-
show less...
-
Broad Inst MIT & Harvard, 7 Cambridge Ctr, Cambridge, MA 02142 USA Harvard Med Sch, Anesthesia Ctr Crit Care Res, Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, 55 Fruit St, Boston, MA 02114 USA. (creator_code:org_t)
- 2022-02-17
- 2022
- English.
-
In: Communications Biology. - : Springer Nature. - 2399-3642. ; 5:1
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://www.nature.c...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The Weddell seal (Leptonychotes weddellii) thrives in its extreme Antarctic environment. We generated the Weddell seal genome assembly and a high-quality annotation to investigate genome-wide evolutionary pressures that underlie its phenotype and to study genes implicated in hypoxia tolerance and a lipid-based metabolism. Genome-wide analyses included gene family expansion/contraction, positive selection, and diverged sequence (acceleration) compared to other placental mammals, identifying selection in coding and non-coding sequence in five pathways that may shape cardiovascular phenotype. Lipid metabolism as well as hypoxia genes contained more accelerated regions in the Weddell seal compared to genomic background. Top-significant genes were SUMO2 and EP300; both regulate hypoxia inducible factor signaling. Liver expression of four genes with the strongest acceleration signals differ between Weddell seals and a terrestrial mammal, sheep. We also report a high-density lipoprotein-like particle in Weddell seal serum not present in other mammals, including the shallow-diving harbor seal. The Antarctic Weddell inhabits one of the most extreme environments on Earth. Comparative genomics with close relatives reveals the specific genetic adaptations for cardiovascular and fat metabolism that enable it to thrive.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Noh, Hyun Ji
-
Turner-Maier, Ja ...
-
Schulberg, S. An ...
-
Fitzgerald, Mich ...
-
Johnson, Jeremy
-
Allen, Kaitlin N ...
-
show more...
-
Huckstadt, Luis ...
-
Batten, Annabell ...
-
Alfoldi, Jessica
-
Costa, Daniel P.
-
Karlsson, Elinor ...
-
Zapol, Warren M.
-
Buys, Emmanuel S ...
-
Lindblad-Toh, Ke ...
-
Hindle, Allyson ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Genetics
- Articles in the publication
-
Communications B ...
- By the university
-
Uppsala University