Probing the relationship between external and internal human exposure of organophosphate flame retardants using pharmacokinetic modelling

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Fältnamn	Indikatorer	Metadata
000		03161nam a2200337 4500
001		oai:DiVA.org:su-141807
003		SwePub
008		170418\| \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1418072 URI
040		a (SwePub)su
041		a engb eng
042		9 SwePub
072	7	a vet2 swepub-contenttype
072	7	a ovr2 swepub-publicationtype
100	1	a Bui, Tuong Thuyu Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi4 aut0 (Swepub:su)thbu0588
245	1 0	a Probing the relationship between external and internal human exposure of organophosphate flame retardants using pharmacokinetic modelling
338		a print2 rdacarrier
520		a Human external exposure (i.e. intake) of organophosphate flame retardants (PFRs) has recently been quantified, but no link has yet been established between external and internal exposure. In this study, we used a pharmacokinetic (PK) model to probe the relationship between external and internal exposure data for three PFRs (EHDPHP, TNBP and TPHP) available for a Norwegian cohort of 61 individuals from 61 different households. Using current literature on metabolism of PFRs, we predicted the human body burden and compared it to the measured serum and urine data for the PFRs metabolites. Unavailable parameters were estimated using a model fitting approach (least squares method) after assigning reasonable constraints on the ranges of fitted parameters. Results showed an acceptable comparison between PK model estimates and measurements (< 10-fold deviation) for EHDPHP. However, a deviation of 10-1000 was observed between PK model estimates and measurements for TNBP and TPHP. Sensitivity and uncertainty analysis on the PK model revealed that EHDPHP results showed higher uncertainty than TNBP or TPHP. However, there are indications that (1) current biomarkers of exposure (i.e. assumed metabolites) for TNBP and TPHP chemicals might not be specific and ultimately affecting the outcome of the modeling, (2) some exposure pathways might be missing. Further research, such as in vivo laboratory metabolism experiments of PFRs including identification of better biomarkers will reduce uncertainties in human exposure assessment.
650	7	a NATURVETENSKAPx Geovetenskap och miljövetenskapx Miljövetenskap0 (SwePub)105022 hsv//swe
650	7	a NATURAL SCIENCESx Earth and Related Environmental Sciencesx Environmental Sciences0 (SwePub)105022 hsv//eng
653		a flame retardants
653		a human exposure
653		a pharmacokinetic modelling
653		a metabolism
700	1	a Xu, Fuchao4 aut
700	1	a Van den Eede, Nele4 aut
700	1	a Palm Cousins, Annau Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi4 aut0 (Swepub:su)anpa5306
700	1	a Covaci, Adrian4 aut
700	1	a Cousins, Ian T.u Stockholms universitet,Institutionen för miljövetenskap och analytisk kemi4 aut0 (Swepub:su)iacou
710	2	a Stockholms universitetb Institutionen för miljövetenskap och analytisk kemi4 org
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-141807

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Av författaren/redakt...: Bui, Tuong Thuy; Xu, Fuchao; Van den Eede, Ne ...; Palm Cousins, An ...; Covaci, Adrian; Cousins, Ian T.

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