WFRF:(Cui M.)
Sökning: WFRF:(Cui M.) > (2000-2004) > Isomer-specific ant...
- 4 av 4
- Föregående post
- Nästa post
- Till träfflistan
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03019naa a2200385 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:1938242 | |
| 003 | SwePub | |
| 008 | 240811s2001 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:19382422 URI |
| 024 | 7 | a https://doi.org/10.2337/diabetes.50.5.11492 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Ryder, JW4 aut |
| 245 | 1 0 | a Isomer-specific antidiabetic properties of conjugated linoleic acid. Improved glucose tolerance, skeletal muscle insulin action, and UCP-2 gene expression |
| 264 | 1 | b American Diabetes Association,c 2001 |
| 520 | a Conjugated linoleic acid (CLA) isomers have a number of beneficial health effects, as shown in biomedical studies with animal models. Previously, we reported that a mixture of CLA isomers improved glucose tolerance in ZDF rats and activated peroxisome proliferator–activated receptor (PPAR)-γ response elements in vitro. Here, our aim was to elucidate the effect(s) of specific CLA isomers on whole-body glucose tolerance, insulin action in skeletal muscle, and expression of genes important in glucose and lipid metabolism. ZDF rats were fed either a control diet (CON), one of two CLA supplemented diets (1.5% CLA) containing differing isoforms of CLA (47% c9,t11; 47.9% c10,t12, 50:50; or 91% c9,t11, c9,t11 isomers), or were pair-fed CON diet to match the intake of 50:50. The 50:50 diet reduced adiposity and improved glucose tolerance compared with all other ZDF treatments. Insulin-stimulated glucose transport and glycogen synthase activity in skeletal muscle were improved with 50:50 compared with all other treatments. Neither phosphatidlyinositol 3-kinase activity nor Akt activity in muscle was affected by treatment. Uncoupling protein 2 in muscle and adipose tissue was upregulated by c9,t11 and 50:50 compared with ZDF controls. PPAR-γ mRNA was downregulated in liver of c9,t11 and pair-fed ZDF rats. Thus, the improved glucose tolerance in 50:50 rats is attributable to, at least in part, improved insulin action in muscle, and CLA effects cannot be explained simply by reduced food intake. | |
| 700 | 1 | a Portocarrero, CP4 aut |
| 700 | 1 | a Song, XM4 aut |
| 700 | 1 | a Cui, L4 aut |
| 700 | 1 | a Yu, M4 aut |
| 700 | 1 | a Combatsiaris, T4 aut |
| 700 | 1 | a Galuska, Du Karolinska Institutet4 aut |
| 700 | 1 | a Bauman, DE4 aut |
| 700 | 1 | a Barbano, DM4 aut |
| 700 | 1 | a Charron, MJ4 aut |
| 700 | 1 | a Zierath, JRu Karolinska Institutet4 aut |
| 700 | 1 | a Houseknecht, KL4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Diabetesd : American Diabetes Associationg 50:5, s. 1149-1157q 50:5<1149-1157x 0012-1797x 1939-327X |
| 856 | 4 | u http://diabetes.diabetesjournals.org/content/50/5/1149.full.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:1938242 |
| 856 | 4 8 | u https://doi.org/10.2337/diabetes.50.5.1149 |
- 4 av 4
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Ryder, JW
- Portocarrero, CP
- Song, XM
- Cui, L
- Yu, M
- Combatsiaris, T
- visa fler...
- Galuska, D
- Bauman, DE
- Barbano, DM
- Charron, MJ
- Zierath, JR
- Houseknecht, KL
- visa färre...
- Artiklar i publikationen
- Diabetes
- Av lärosätet
- Karolinska Institutet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
