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FältnamnIndikatorerMetadata
00006258naa a2200829 4500
001oai:lup.lub.lu.se:44513f7b-2ec2-40d6-8ec0-514890aa1305
003SwePub
008200117s2020 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:144837311
0247 a https://lup.lub.lu.se/record/44513f7b-2ec2-40d6-8ec0-514890aa13052 URI
0247 a https://doi.org/10.1016/j.hpb.2019.12.0082 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1448373112 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a D'Souza, Melroy A.u Karolinska Institutet4 aut
2451 0a Hepatopancreatoduodenectomy –a controversial treatment for bile duct and gallbladder cancer from a European perspective
264 1b Elsevier BV,c 2020
300 a 10 s.
520 a Background: Hepatopancreatoduodenectomy (HPD) is an aggressive operation for treatment of advanced bile duct and gallbladder cancer associated with high perioperative morbidity and mortality, and uncertain oncological benefit in terms of survival. Few reports on HPD from Western centers exist. The purpose of this study was to evaluate safety and efficacy for HPD in European centers. Method: Members of the European-African HepatoPancreatoBiliary Association were invited to report all consecutive patients operated with HPD for bile duct or gallbladder cancer between January 2003 and January 2018. The patient and tumor characteristics, perioperative and survival outcomes were analyzed. Results: In total, 66 patients from 19 European centers were included in the analysis. 90-day mortality rate was 17% and 13% for bile duct and gallbladder cancer respectively. All factors predictive of perioperative mortality were patient and disease-specific. The three-year overall survival excluding 90-day mortality was 80% for bile duct and 30% for gallbladder cancer (P = 0.013). In multivariable analysis R0-resection had a significant impact on overall survival. Conclusion: HPD, although being associated with substantial perioperative mortality, can offer a survival benefit in patient subgroups with bile duct cancer and gallbladder cancer. To achieve negative resection margins is paramount for an improved survival outcome.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
7001 a Valdimarsson, Valentinus T.u Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)va4706va
7001 a Campagnaro, Tommasou University Hospital Verona4 aut
7001 a Cauchy, Francoisu Beaujon Hospital4 aut
7001 a Chatzizacharias, Nikolaos A.u New Queen Elizabeth Hospital4 aut
7001 a D'Hondt, Mathieu4 aut
7001 a Dasari, Bobbyu New Queen Elizabeth Hospital4 aut
7001 a Ferrero, Alessandrou Mauriziano Hospital, Turin4 aut
7001 a Franken, Lotte C.u Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Fusai, Giuseppeu Great Ormond Street Hospital4 aut
7001 a Guglielmi, Alfredou University Hospital Verona4 aut
7001 a Hagendoorn, Jeroenu University Medical Center Utrecht4 aut
7001 a Hidalgo Salinas, Camilau Great Ormond Street Hospital4 aut
7001 a Hoogwater, Frederik J.H.u University Medical Center Groningen4 aut
7001 a Jorba, Rosau Hospital Joan XXIII4 aut
7001 a Karanjia, Nariman4 aut
7001 a Knoefel, Wolfram T.u University Hospital of Düsseldorf4 aut
7001 a Kron, Philippu Leeds Teaching Hospitals NHS Trust4 aut
7001 a Lahiri, Rajiv4 aut
7001 a Langella, Serenau Mauriziano Hospital, Turin4 aut
7001 a Le Roy, Bertrandu Beaujon Hospital4 aut
7001 a Lehwald-Tywuschik, Nadjau University Hospital of Düsseldorf4 aut
7001 a Lesurtel, Mickaelu Claude Bernard University Lyon 14 aut
7001 a Li, Junu University Medical Center Hamburg-Eppendorf4 aut
7001 a Lodge, J. Peter A.u Leeds Teaching Hospitals NHS Trust4 aut
7001 a Martinou, Erini4 aut
7001 a Molenaar, Izaak Q.u University Medical Center Utrecht4 aut
7001 a Nikov, Andreju The Military University Hospital Prague4 aut
7001 a Poves, Ignasiu Hospital del Mar Medical Research Institute4 aut
7001 a Rassam, Fadiu Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Russolillo, Nadiau Mauriziano Hospital, Turin4 aut
7001 a Soubrane, Olivieru Beaujon Hospital4 aut
7001 a Stättner, Stefanu Medical University of Innsbruck4 aut
7001 a van Dam, Ronald M.u Yukioka Hospital4 aut
7001 a van Gulik, Thomas M.u Academic Medical Center of University of Amsterdam (AMC)4 aut
7001 a Serrablo, Alejandrou Miguel Servet University Hospital4 aut
7001 a Gallagher, Tom M.u St Vincent's University Hospital4 aut
7001 a Sturesson, Christianu Karolinska Institutet4 aut0 (Swepub:lu)med-cst
7102 a Karolinska Institutetb Kirurgi, Lund4 org
7102 a E-AHPBA scientific and research committee
7730 t HPBd : Elsevier BVg 22:9, s. 1339-1348q 22:9<1339-1348x 1365-182X
7730 t HPB : the official journal of the International Hepato Pancreato Biliary Associationd : Elsevier BVg 22:9, s. 1339-1348q 22:9<1339-1348x 1477-2574
8564 u http://dx.doi.org/10.1016/j.hpb.2019.12.008y FULLTEXT
8564 u http://www.hpbonline.org/article/S1365182X19332241/pdf
8564 8u https://lup.lub.lu.se/record/44513f7b-2ec2-40d6-8ec0-514890aa1305
8564 8u https://doi.org/10.1016/j.hpb.2019.12.008
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:144837311

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