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Sökning: WFRF:(Elander Johanna) > (2020-2024) > Efficacy of mistlet...

  • Wode, KathrinUmeå universitet,Onkologi,Institutionen för omvårdnad,Umea Univ, Sweden; Karolinska Univ Hosp, Sweden; Reg Canc Ctr Stockholm Gotland, Sweden (författare)

Efficacy of mistletoe extract as a complement to standard treatment in advanced pancreatic cancer : study protocol for a multicentre, parallel group, double-blind, randomised, placebo-controlled clinical trial (MISTRAL)

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-09-11
  • BioMed Central,2020
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-175651
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-175651URI
  • https://doi.org/10.1186/s13063-020-04581-yDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-170642URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:144677642URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies|Oncological Department Endowment Fund at Karolinska University Hospital; Cancer Research Funds of Radiumhemmet; Gyllenberg foundation; Ekhaga foundation; Dagmar Ferbs Memorial fund; Cancer Research Foundation in Northern Sweden; Sjoberg Foundation; Umea University
  • Background: Most pancreatic cancer patients present with advanced stage at diagnosis with extremely short expected survival and few treatment options. A multimodal palliative approach is necessary for symptom relief and optimisation of health-related quality of life. In a recent open-label trial of mistletoe extract for advanced pancreatic cancer patients not eligible for chemotherapy, promising results on improved overall survival and better health-related quality of life were reported.The objective of the present study is to assess the value of mistletoe extract as a complement to standard treatment (palliative chemotherapy or best supportive care) in advanced pancreatic cancer patients with regard to overall survival and health-related quality of life.Methods: The trial is prospective, randomised, double-blind, multicentre, parallel group and placebo-controlled. In total, 290 participants are randomly assigned to placebo or mistletoe extract given subcutaneously in increasing dosage from 0.01 to 20 mg three times per week for 9 months. Stratification is performed for site and palliative chemotherapy. Main inclusion criteria are advanced pancreatic cancer and Eastern Cooperative Oncology Group performance status 0 to 2; main exclusion criteria are life expectancy less than 4 weeks and neuroendocrine tumour of the pancreas. Two ancillary studies on sub-sets of participants are nested in the trial: a biomarker study collecting blood samples and a cross-sectional qualitative study with semi-structured face-to-face interviews.Discussion: To our knowledge, this is the first placebo-controlled randomised trial assessing the impact of mistletoe extract as a complement to standard treatment on overall survival and health-related quality of life in patients with advanced pancreatic cancer. The presented trial with its two nested ancillary studies exploring biomarkers and patient experiences is expected to give new insights into the treatment of advanced pancreatic cancer.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Nordberg, Johanna HoekKarolinska Institutet (författare)
  • Kienle, Gunver S.Univ Freiburg, Germany; Univ Witten Herdecke, Germany (författare)
  • Elander, Nils,1980-Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US(Swepub:liu)nilel58 (författare)
  • Bernhardson, Britt-MarieKarolinska Institutet (författare)
  • Sunde, BeritKarolinska Institutet,Umeå universitet,Institutionen för omvårdnad,Umea Univ, Sweden; Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden (författare)
  • Sharp, LenaKarolinska Institutet (författare)
  • Henriksson, RogerUmeå universitet,Onkologi,Umea Univ, Sweden; Norrland Univ Hosp, Sweden(Swepub:umu)rohe0003 (författare)
  • Fransson, PerUmeå universitet,Institutionen för omvårdnad,Umea Univ, Sweden; Norrland Univ Hosp, Sweden(Swepub:umu)perfrn96 (författare)
  • Umeå universitetOnkologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Trials: BioMed Central21:11745-6215

Internetlänk

Hitta via bibliotek

  • Trials (Sök värdpublikationen i LIBRIS)

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