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Sökning: WFRF:(Engebretsen Ingunn M S) > Severe events in th...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004317naa a2200397 4500
001oai:DiVA.org:uu-232792
003SwePub
008140925s2014 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2327922 URI
0247 a https://doi.org/10.1111/tmi.123552 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Doherty, Tanyau Health Systems Research Unit, Medical Research Council, Cape Town, South Africa4 aut
2451 0a Severe events in the first 6 months of life in a cohort of HIV-unexposed infants from South Africa :b effects of low birthweight and breastfeeding status
264 c 2014-07-23
264 1b Wiley,c 2014
338 a print2 rdacarrier
520 a OBJECTIVE:To report on risk factors for severe events (hospitalisation or infant death) within the first half of infancy amongst HIV-unexposed infants in South Africa.METHODS:South African data from the multisite community-based cluster-randomised trial PROMISE EBF promoting exclusive breastfeeding in three sub-Saharan countries from 2006 to 2008 were used. The South African sites were Paarl in the Western Cape Province, and Umlazi and Rietvlei in KwaZulu-Natal. This analysis included 964 HIV-negative mother-infant pairs. Data on severe events and infant feeding practices were collected at 3, 6, 12 and 24 weeks post-partum. We used a stratified extended Cox model to examine the association between the time to the severe event and covariates including birthweight, with breastfeeding status as a time-dependent covariate.RESULTS:Seventy infants (7%) experienced a severe event. The median age at first hospitalisation was 8 weeks, and the two main reasons for hospitalisation were cough and difficult breathing followed by diarrhoea. Stopping breastfeeding before 6 months (HR 2.4; 95% CI 1.2-5.1) and low birthweight (HR 2.4; 95% CI 1.3-4.3) were found to increase the risk of a severe event, whilst maternal completion of high school education was protective (HR 0.3; 95% CI 0.1-0.7).CONCLUSIONS:A strengthened primary healthcare system incorporating promotion of breastfeeding and appropriate caring practices for low birthweight infants (such as kangaroo mother care) are critical. Given the leading reasons for hospitalisation, early administration of oral rehydration therapy and treatment of suspected pneumonia are key interventions needed to prevent hospitalisation in young infants.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
7001 a Jackson, Debrau chool of Public Health, University of the Western Cape, Cape Town, South Africa4 aut
7001 a Swanevelder, Sonjau Biostatistics Unit, Medical Research Council, Cape Town, South Africa4 aut
7001 a Lombard, Carlu Biostatistics Unit, Medical Research Council, Cape Town, South Africa4 aut
7001 a Engebretsen, Ingunn M Su Centre for International Health, University of Bergen, Norway4 aut
7001 a Tylleskär, Thorkildu Centre for International Health, University of Bergen, Norway4 aut
7001 a Goga, Ameenau Health Systems Research Unit, Medical Research Council, Cape Town, South Africa4 aut
7001 a Ekström, Eva-Charlotte,d 1956-u Uppsala universitet,Internationell mödra- och barnhälsovård (IMCH),Internationell sexuell och reproduktiv hälsa/Larsson4 aut0 (Swepub:uu)loeks254
7001 a Sanders, Davidu School of Public Health, University of the Western Cape, Cape Town, South Africa4 aut
7102 a Health Systems Research Unit, Medical Research Council, Cape Town, South Africab chool of Public Health, University of the Western Cape, Cape Town, South Africa4 org
7730 t Tropical medicine & international healthd : Wileyg 19:10, s. 1162-1169q 19:10<1162-1169x 1360-2276x 1365-3156
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/tmi.12355
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-232792
8564 8u https://doi.org/10.1111/tmi.12355

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