Neutron Reflectometry reveals the interaction between functionalized SPIONs and the surface of lipid bilayers

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Neutron Reflectometry reveals the interaction between functionalized SPIONs and the surface of lipid bilayers

Luchini, Alessandra (författare): Univ Napoli Federico 11, Dipartimento Sci Chim, Complesso Univ Monte S Angelo,Via Cintia, I-80126 Naples, Italy.;CSGI Consorzio Interuniv Sviluppo Sistemi Grande, Sesto Fiorentino, Italy.;Inst Laue Langevin, BP 156,71 Ave Martyrs, F-38000 Grenoble, France.,Institut Laue Langevin,University of Naples Federico II

Gerelli, Yuri (författare): Inst Laue Langevin, BP 156,71 Ave Martyrs, F-38000 Grenoble, France.,Institut Laue Langevin

Fragneto, Giovanna (författare): Inst Laue Langevin, BP 156,71 Ave Martyrs, F-38000 Grenoble, France.,Institut Laue Langevin

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Nylander, Tommy (författare): Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH

Pálsson, Gunnar K. (författare): Uppsala University,Uppsala universitet,Materialfysik,Inst Laue Langevin, 71 Ave Martyrs, F-38000 Grenoble, France.,Institut Laue Langevin

Appavou, Marie-Sousai (författare): Garching Forschungszentrum, Julich Ctr Neutron Sci, Lichtenbergstr 1, D-85747 Garching, Germany.,Jülich Research Centre

Paduano, Luigi (författare): Univ Napoli Federico 11, Dipartimento Sci Chim, Complesso Univ Monte S Angelo,Via Cintia, I-80126 Naples, Italy.;CSGI Consorzio Interuniv Sviluppo Sistemi Grande, Sesto Fiorentino, Italy.,University of Naples Federico II

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Univ Napoli Federico 11, Dipartimento Sci Chim, Complesso Univ Monte S Angelo,Via Cintia, I-80126 Naples, Italy;CSGI Consorzio Interuniv Sviluppo Sistemi Grande, Sesto Fiorentino, Italy.;Inst Laue Langevin, BP 156,71 Ave Martyrs, F-38000 Grenoble, France. Institut Laue Langevin (creator_code:org_t)

ELSEVIER SCIENCE BV, 2017
2017
Engelska.
Ingår i: Colloids and Surfaces B. - : ELSEVIER SCIENCE BV. - 0927-7765 .- 1873-4367. ; 151, s. 76-87

Relaterad länk:: http://dx.doi.org/10...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.1...; https://lup.lub.lu.s...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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The safe application of nanotechnology devices in biomedicine requires fundamental understanding on how they interact with and affect the different components of biological systems. In this respect, the cellular membrane, the cell envelope, certainly represents an important target or barrier for nanosystems. Here we report on the interaction between functionalized SuperParamagnetic Iron Oxide Nanoparticles (SPIONs), promising contrast agents for Magnetic Resonance Imaging (MRI), and lipid bilayers that mimic the plasma membrane. Neutron Reflectometry, supported by Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) experiments, was used to characterize this interaction by varying both SPION coating and lipid bilayer composition. In particular, the interaction of two different SPIONs, functionalized with a cationic surfactant and a zwitterionic phospholipid, and lipid bilayers, containing different amount of cholesterol, were compared. The obtained results were further validated by Dynamic Light Scattering (DLS) measurements and Cryogenic Transmission Electron Microscopy (Cryo-TEM) images. None of the investigated functionalized SPIONs were found to disrupt the lipid membrane. However, in all case we observed the attachment of the functionalized SPIONs onto the surface of the bilayers, which was affected by the bilayer rigidity, i.e. the cholesterol concentration.

Ämnesord

NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)

Nyckelord

SuperParamagnetic Iron Oxide
Nanoparticles (SPIONs)
Lysophosphatidylcholine
Supported lipid bilayers
Cholesterol
Neutron reflectometry
Cholesterol
Lysophosphatidylcholine
Neutron reflectometry
SuperParamagnetic Iron Oxide Nanoparticles (SPIONs)
Supported lipid bilayers

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Av författaren/redakt...: Luchini, Alessan ...; Gerelli, Yuri; Fragneto, Giovan ...; Nylander, Tommy; Pálsson, Gunnar ...; Appavou, Marie-S ...; visa fler...; Paduano, Luigi; visa färre...

Om ämnet

NATURVETENSKAP: NATURVETENSKAP; och Biologi; och Biofysik

NATURVETENSKAP: NATURVETENSKAP; och Kemi; och Fysikalisk kemi

Artiklar i publikationen: Colloids and Sur ...

Av lärosätet: Uppsala universitet; Lunds universitet

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