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Sökning: WFRF:(Guillou P. J.) > (2020-2024) > Detection in seized...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005377naa a2200493 4500
001oai:DiVA.org:liu-200037
003SwePub
008240112s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2000372 URI
0247 a https://doi.org/10.1002/dta.36092 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Norman, Caitlynu Univ Dundee, Scotland4 aut
2451 0a Detection in seized samples, analytical characterization, and in vitro metabolism of the newly emerged 5-bromo-indazole-3-carboxamide synthetic cannabinoid receptor agonists
264 c 2023
264 1b WILEY,c 2023
338 a print2 rdacarrier
500 a Funding Agencies|Fonds Wetenschappelijk Onderzoek; Leverhulme Trust [RC-2015-01]; National Institute of Justice [2020-DQ-BX-0007]; Sweden's Innovation Agency [2019-03566]; European Commission; European Union's Horizon 2020; Linkoping University; Scottish Prison Service; Office of Justice Programs; US Department of Justice; Research Foundation Flanders [1S54521N]
520 a Synthetic cannabinoid receptor agonists (SCRAs) are a diverse class of new psychoactive substances (NPS) and new structural scaffolds have emerged on the recreational drug market since the enactment of Chinese SCRA analog controls in 2021. This study reports the first SCRAs to be detected with a bromide at the 5 position (5 ' Br) on the phenyl ring of the indazole core and without a tail moiety. ADB-5 ' Br-INACA (ADMB-5 ' Br-INACA) and MDMB-5 ' Br-INACA were detected in seized samples from Scottish prisons, Belgian customs, and US forensic casework. The brominated analog with a tail moiety, ADB-5 ' Br-BUTINACA (ADMB-5 ' Br-BUTINACA), was also detected in Scottish prisons and US forensic casework. The metabolites of these compounds and the predicted compound MDMB-5 ' Br-BUTINACA were identified through incubation with primary human hepatocytes to aid in their toxicological identification. The bromide on the indazole remains intact on metabolites, allowing these compounds to be easily distinguished in toxicological samples from their non-brominated analogs. Glucuronidation was more common for tail-less analogs than their butyl tail-containing counterparts. Forensic toxicologists are advised to update their analytical methods with the characteristic ions for these compounds, as well as their anticipated urinary markers: amide hydrolysis and monoOH at tert-butyl metabolites (after beta-glucuronidase treatment) for ADB-5 ' Br-INACA; monoOH at tert-butyl and amide hydrolysis metabolites for ADB-5 ' Br-BUTINACA; and ester hydrolysis metabolites with additional metabolites for MDMB-5 ' Br-INACA and MDMB-5 ' Br-BUTINACA. Toxicologists should remain vigilant to the emergence of new SCRAs with halogenation of the indazole core and tail-less analogs, which have already started to emerge. This study reports the detection of the new synthetic cannabinoids ADB-5 ' Br-INACA and MDMB-5 ' Br-INACA in Scotland, Belgium, and the US, and ADB-5 ' Br-BUTINACA in Scotland and the US. These compounds, along with the predicted compound MDMB-5 ' Br-BUTINACA, were incubated with primary human hepatocytes to examine metabolic pathways and aid in toxicological identification.image
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Läkemedelskemi0 (SwePub)301032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medicinal Chemistry0 (SwePub)301032 hsv//eng
653 a brominated synthetic cannabinoid receptor agonists; forensic toxicology; metabolism; new psychoactive substances; prison seizures
7001 a Webling, Kristinu Linköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten4 aut0 (Swepub:liu)kriwe90
7001 a Kyslychenko, Oleksandrau Linköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten4 aut0 (Swepub:liu)oleky05
7001 a Reid, Robertu Univ Dundee, Scotland4 aut
7001 a Krotulski, Alex J.u Fredric Rieders Family Fdn, PA USA4 aut
7001 a Farrell, Ryanu Indianapolis Marion Cty Forens Serv Agcy, IN USA4 aut
7001 a Deventer, Marie H.u Univ Ghent, Belgium4 aut
7001 a Liu, Huilingu Chiron AS, Norway4 aut
7001 a Connolly, Matthew J.u Chiron AS, Norway4 aut
7001 a Guillou, Claudeu European Commiss, Italy4 aut
7001 a Vinckier, Inge M. J.u Lab Customs & Excises, Belgium4 aut
7001 a Logan, Barry K.u Fredric Rieders Family Fdn, PA USA; NMS Labs, PA USA4 aut
7001 a NicDaeid, Niamhu Univ Dundee, Scotland4 aut
7001 a McKenzie, Craigu Univ Dundee, Scotland; Chiron AS, Norway4 aut
7001 a Stove, Christophe P.u Univ Ghent, Belgium4 aut
7001 a Green, Henriku Linköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Natl Board Forens Med, Dept Forens Genet & Forens Toxicol, Linkoping, Sweden4 aut0 (Swepub:liu)hengr89
7102 a Univ Dundee, Scotlandb Avdelningen för klinisk kemi och farmakologi4 org
7730 t Drug Testing and Analysisd : WILEYx 1942-7603x 1942-7611
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-200037
8564 8u https://doi.org/10.1002/dta.3609

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