Health and persistent functional late effects in adult survivors of childhood CNS tumours: a population-based cohort study.

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Health and persistent functional late effects in adult survivors of childhood CNS tumours: a population-based cohort study.

Boman, K K (författare): Karolinska Institutet,Karolinska Institutet, Department of Women’s and Children’s Health, Childhood Cancer Research Unit, Astrid Lindgren Children’s Hospital, S-17176 Stockholm, Sweden

Hovén, E (författare): Karolinska Institutet,Karolinska Institutet, Department of Women’s and Children’s Health, Childhood Cancer Research Unit, Astrid Lindgren Children’s Hospital, S-17176 Stockholm, Sweden

Anclair, Malin (författare): Karolinska Institutet, Department of Women’s and Children’s Health, Childhood Cancer Research Unit, Astrid Lindgren Children’s Hospital, S-17176 Stockholm, Sweden

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Lannering, Birgitta, 1948 (författare): Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,University of Gothenburg, Department of Pediatrics, Pediatric Oncology, Queen Silvia’s Children’s Hospital, SU/Östra, S-416 85 Gothenburg, Sweden

Gustafsson, G. (författare): Karolinska Institutet, Department of Women’s and Children’s Health, Childhood Cancer Research Unit, Astrid Lindgren Children’s Hospital, S-17176 Stockholm, Sweden

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Elsevier BV, 2009
2009
Engelska.
Ingår i: European journal of cancer (Oxford, England : 1990). - : Elsevier BV. - 1879-0852 .- 0959-8049. ; 45:14, s. 2552-61

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Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Survivors of central nervous system (CNS) tumours are particularly vulnerable to tumour- and treatment-related disability. We present the incidence of specific and overall functional and health-related late effects in a national adult survivor cohort. Diagnostic subgroups at particular risk for persistent sequels are identified. Data collection targeted 708 eligible >18 years old survivors, 708 parent proxies and 1000 general population controls. Functional disability including sensory and cognitive impairment, emotional status and pain was assessed using the Health Utilities Index Mark 2/3 (HUI2/3). Survivors and controls, and diagnostic subgroups were contrasted to identify the general and relative risk for late effects by sub-diagnosis. Survivors had persistent late effects in sensation, mobility, self-care and cognition. Deficits in these domains indicated clinically important disability in overall health, although indices of emotion and pain were unaffected compared to controls. Late effects tended to aggravate with time, and female survivors had poorer health. Oligodendroglioma, mixed/unspecified glioma, intracranial germ cell tumour and medulloblastoma survivors had poorest overall health. Least late effects were found for other specified/unspecified CNS tumours (including meningeoma and nerve sheath tumours), and for astrocytoma. An impact on educational, vocational and family-related outcomes, and higher utilisation of social insurance or government subsidies validated health-related sequelae in adulthood. Comparisons with controls confirm persistent disability in multiple functional domains in adult CNS tumour survivors. The heightened proportion of survivors presenting severe disability is a factor that specifically differentiates survivors from controls, although diagnostic subgroups differ significantly regarding the amount and severity of late effects.

Ämnesord

SAMHÄLLSVETENSKAP -- Annan samhällsvetenskap -- Övrig annan samhällsvetenskap (hsv//swe)
SOCIAL SCIENCES -- Other Social Sciences -- Other Social Sciences not elsewhere specified (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Activities of Daily Living
Adolescent
Adult
Age Factors
Case-Control Studies
Central Nervous System Neoplasms
complications
psychology
therapy
Child
Child
Preschool
Cognition Disorders
epidemiology
Cohort Studies
Female
Health Status
Humans
Incidence
Male
Pain
epidemiology
Quality of Life
Risk Factors
Self Care
Sensation Disorders
epidemiology
Survivors
psychology
Sweden
epidemiology
Young Adult

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European journal of cancer (Oxford, England : 1990) (Sök värdpublikationen i LIBRIS)

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Av författaren/redakt...: Boman, K K; Hovén, E; Anclair, Malin; Lannering, Birgi ...; Gustafsson, G.

Om ämnet

SAMHÄLLSVETENSKAP: SAMHÄLLSVETENSKA ...; och Annan samhällsve ...; och Övrig annan samh ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Cell och molekyl ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: European journal ...

Av lärosätet: Göteborgs universitet; Uppsala universitet; Karolinska Institutet; Luleå tekniska universitet

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