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Myocardial efficien...
Myocardial efficiency in patients with different aetiologies and stages of heart failure
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- Berg Hansen, Kristoffer (författare)
- Aarhus Univ Hosp, Dept Cardiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.;Aarhus Univ, Fac Hlth, Dept Clin Med, Aarhus N, Denmark.
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- Sörensen, Jens (författare)
- Uppsala universitet,Radiologi,Aarhus Univ, Fac Hlth, Dept Clin Med, Aarhus N, Denmark.;Aarhus Univ Hosp, Dept Nucl Med, Aarhus N, Denmark.;Aarhus Univ Hosp, PET Ctr, Aarhus N, Denmark.
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- Hansson, Nils Henrik (författare)
- Aarhus Univ Hosp, Dept Cardiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.
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- Nielsen, Roni (författare)
- Aarhus Univ Hosp, Dept Cardiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.
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- Larsen, Anders Hostrup (författare)
- Aarhus Univ Hosp, Dept Cardiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.
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- Frøkiaer, Jørgen (författare)
- Aarhus Univ, Fac Hlth, Dept Clin Med, Aarhus N, Denmark.
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- Tolbod, Lars Poulsen (författare)
- Aarhus Univ Hosp, Dept Nucl Med, Aarhus N, Denmark.;Aarhus Univ Hosp, PET Ctr, Aarhus N, Denmark.
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- Gormsen, Lars Christian (författare)
- Aarhus Univ, Fac Hlth, Dept Clin Med, Aarhus N, Denmark.;Aarhus Univ Hosp, Dept Nucl Med, Aarhus N, Denmark.;Aarhus Univ Hosp, PET Ctr, Aarhus N, Denmark.
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- Harms, Hendrik Johannes (författare)
- Aarhus Univ Hosp, Dept Nucl Med, Aarhus N, Denmark.;Aarhus Univ Hosp, PET Ctr, Aarhus N, Denmark.
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- Wiggers, Henrik (författare)
- Aarhus Univ Hosp, Dept Cardiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.;Aarhus Univ, Fac Hlth, Dept Clin Med, Aarhus N, Denmark.
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Aarhus Univ Hosp, Dept Cardiol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark;Aarhus Univ, Fac Hlth, Dept Clin Med, Aarhus N, Denmark. Radiologi (creator_code:org_t)
- 2021-11-09
- 2022
- Engelska.
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Ingår i: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 23:3, s. 328-337
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aims: Myocardial external efficiency (MEE) is the ratio of cardiac work in relation with energy expenditure. We studied MEE in patients with different aetiologies and stages of heart failure (HF) to discover the role and causes of deranged MEE. In addition, we explored the impact of patient characteristics such as sex, body mass index (BMI), and age on myocardial energetics.Methods and results: Cardiac energetic profiles were assessed with C-11-acetate positron emission tomography (PET) and left ventricular ejection fraction (LVEF) was acquired with echocardiography. MEE was studied in 121 participants: healthy controls (n = 20); HF patients with reduced (HFrEF; n = 25) and mildly reduced (HFmrEF; n = 23) LVEF; and patients with asymptomatic (AS-asymp; n = 38) and symptomatic (AS-symp; n = 15) aortic stenosis (AS). Reduced MEE coincided with symptoms of HF irrespective of aetiology and declined in tandem with deteriorating LVEF. Patients with AS-symp and HFmrEF had reduced MEE as compared with controls (22.2 +/- 4.9%, P = 0.041 and 20.0 +/- 4.2%, P < 0.001 vs. 26.1 +/- 5.8% in controls) and a further decline was observed in patients with HFrEF (14.7 +/- 6.3%, P < 0.001). Disproportionate left ventricular hypertrophy was a major cause of reduced MEE. Female sex (P < 0.001), a lower BMI (P = 0.001), and advanced age (P = 0.03) were associated with a lower MEE.Conclusion: MEE was reduced in patients with HFrEF, HFmrEF, and HF due to pressure overload and MEE may therefore constitute a treatment target in HF. Patients with LVH, advanced age, female sex, and low BMI had more pronounced reduction in MEE and personalized treatment within these patient subgroups could be relevant.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- heart failure
- hypertrophy
- left ventricular ejection fraction
- myocardial external efficiency
- myocardial oxygen consumption
- positron emission tomography
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Berg Hansen, Kri ...
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Sörensen, Jens
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Hansson, Nils He ...
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Nielsen, Roni
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Larsen, Anders H ...
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Frøkiaer, Jørgen
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Tolbod, Lars Pou ...
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Gormsen, Lars Ch ...
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Harms, Hendrik J ...
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Wiggers, Henrik
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European Heart J ...
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