WFRF:(Hellerbrand Claus)
Sökning: WFRF:(Hellerbrand Claus) > UVB radiation repre...
UVB radiation represses CYLD expression in melanocytes
-
- Kuphal, Silke (författare)
- Friedrich-Alexander University Erlangen-Nürnberg
-
- Schneider, Nadja (författare)
- Friedrich-Alexander University Erlangen-Nürnberg
-
- Massoumi, Ramin (författare)
- Lund University,Lunds universitet,Molekylär tumörpatologi,Forskargrupper vid Lunds universitet,Molecular Tumor Pathology,Lund University Research Groups
- visa fler...
- visa färre...
- (creator_code:org_t)
- 2017-10-03
- 2017
- Engelska 7 s.
- Ingår i: Oncology Letters. - : Spandidos Publications. - 1792-1074 .- 1792-1082. ; 14:6, s. 7262-7268
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- CYLD lysine 63 deubiquitinase (CYLD) was originally identified as a tumor suppressor that is mutated in familial cylindromatosis. Unlike in cylindromatosis, downregulation of the deubiquitinase CYLD in melanoma, a highly aggressive tumor, is not caused by mutations in the CYLD gene, but rather by a constitutive and high expression of the snail family transcriptional repressor 1 (SNAIL1). A reduced CYLD level leads to B-cell lymphoma-3/p50/p52-dependent nuclear factorκB activation, which in turn triggers the expression of genes such as cyclin D1 and N-cadherin. Elevated levels of cyclin D1 and N-cadherin promote melanoma proliferation and invasion. By analyzing the regulation of CYLD expression in melanocytes, the present study identified a signaling pathway that is regulated in response to ultraviolet B (UVB) radiation in melanocytes. UVB light leads to an extracellular signal-regulated kinase-mediated induction of SNAIL1 and subsequent downregulation of CYLD expression in normal human epithelial melanocytes. The UVB-mediated suppression of CYLD in melanocytes may have a key role in the reaction to UV stimuli, and may also potentially be involved in the early malignant transformation processes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- CYLD
- ERK
- Melanocytes
- SNAIL1
- UVB
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta mer i SwePub
- Av författaren/redakt...
- Kuphal, Silke
- Schneider, Nadja
- Massoumi, Ramin
- Hellerbrand, Cla ...
- Bosserhoff, Anja ...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Cancer och onkol ...
- Artiklar i publikationen
- Oncology Letters
- Av lärosätet
- Lunds universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
